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West China Hospital of Stomatology, Sichuan University

1 ARTICLES PUBLISHED IN JoVE

Medicine

Creating a Box-Cavity Defect Model in the Cortical Bone of Rat Femora

Yiyun Chen^1,2, Jiayi Wu^1,2, Feifei Li¹, Ling Ye^1,2, Haisheng Wang¹

¹State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, ²Department of Endodontics, West China Hospital of Stomatology, Sichuan University

Here, we present a protocol for creating a box-cavity defect in rat femoral diaphysis tissue. This model can assess biomaterial performance under biomechanical stress and explore mechanisms of bone regeneration related to intramembranous osteogenesis.