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University of Munich Medical Center

2 ARTICLES PUBLISHED IN JoVE

Medicine

A Murine Model of Subarachnoid Hemorrhage

Kathrin Schüller¹, Dominik Bühler¹, Nikolaus Plesnila¹

¹Institute for Stroke and Dementia Research (ISD), University of Munich Medical Center

A standardized mouse model of subarachnoid hemorrhage by intraluminal Circle of Willis perforation is described. Vessel perforation and subarachnoid bleeding are monitored by intracranial pressure monitoring. In addition various vital parameters are recorded and controlled to maintain physiologic conditions.

Medicine

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

Gemma Llovera^*1,2, Stefan Roth^*1,2, Nikolaus Plesnila^1,2, Roland Veltkamp^3,4, Arthur Liesz^1,2

¹Institute for Stroke and Dementia Research, University Hospital Munich, ²Munich Cluster for Systems Neurology (SyNergy), ³Department of Neurology, University Heidelberg, ⁴Imperial College, Charing Cross Hospital

Various murine models of middle cerebral artery occlusion (MCAO) are widely used in experimental brain research. Here, we demonstrate the model of transcranial permanent distal MCAO which produces consistent cortical infarction of a size corresponding to damage imposed by the majority of human ischemic strokes.