University of Munich Medical Center
2 ARTICLES PUBLISHED IN JoVE
Medicine
A Murine Model of Subarachnoid Hemorrhage
Kathrin Schüller 1, Dominik Bühler 1, Nikolaus Plesnila 1
1Institute for Stroke and Dementia Research (ISD), University of Munich Medical Center
A standardized mouse model of subarachnoid hemorrhage by intraluminal Circle of Willis perforation is described. Vessel perforation and subarachnoid bleeding are monitored by intracranial pressure monitoring. In addition various vital parameters are recorded and controlled to maintain physiologic conditions.
Medicine
Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery
Gemma Llovera *1,2, Stefan Roth *1,2, Nikolaus Plesnila 1,2, Roland Veltkamp 3,4, Arthur Liesz 1,2
1Institute for Stroke and Dementia Research, University Hospital Munich, 2Munich Cluster for Systems Neurology (SyNergy), 3Department of Neurology, University Heidelberg, 4Imperial College, Charing Cross Hospital
Various murine models of middle cerebral artery occlusion (MCAO) are widely used in experimental brain research. Here, we demonstrate the model of transcranial permanent distal MCAO which produces consistent cortical infarction of a size corresponding to damage imposed by the majority of human ischemic strokes.
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