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University of Strasbourg

1 ARTICLES PUBLISHED IN JoVE

Medicine

In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis

Guillaume Bierry^1,2, Sophie Lefevre^2,3, Jean-Louis Dietemann¹, François Jehl^2,3

¹Department of Radiology, University Hospital of Strasbourg, ²EA 3432, University of Strasbourg, ³Department of Bacteriology, University Hospital of Strasbourg

We demonstrate how to perform macrophage MR imaging using ultrasmall superparamagnetic contrast agent (USPIO) in septic arthritis, allowing an initial and longitudinal in vivo non-invasive evaluation of macrophages infiltration and an assessment of therapy efficacy.