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Academy of Scientific and Innovative Research (AcSIR), New Delhi, India

1 ARTICLES PUBLISHED IN JoVE

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Neuroscience

A Simple Alternative to Stereotactic Injection for Brain Specific Knockdown of miRNA
Hemant Suryawanshi *1, Mayuresh Anant Sarangdhar *1,2, Manika Vij 1,2, Reema Roshan 1, Vijay Pal Singh 1, Munia Ganguli 1, Beena Pillai 1,2
1CSIR-Institute of Genomics and Integrative Biology, New Delhi, India, 2Academy of Scientific and Innovative Research (AcSIR), New Delhi, India

MicroRNAs play crucial roles in the brain and are potential targets for modeling neuro-degeneration. However, perturbing miRNA levels is challenging due to the short length of miRNA and inaccessibility of the brain tissue. This video presents a method for antagomir design and brain specific delivery using a neuropeptide in mice.

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