Easy and Accurate Mechano-profiling on Micropost ArraysNils Goedecke 1, Maja Bollhalder 1, Remo Bernet 1, Unai Silvan 1, Jess Snedeker 1,2
1University of Zurich, Balgrist University Hospital, 2Institute for Biomechanics, ETH Zurich
Described are protocols for quantifying mechanical interactions between adherent cells and microstructured substrates. These interactions are closely linked to essential cell behaviors including migration, proliferation, differentiation, and apoptosis. The protocols present an open-source image analysis software called MechProfiler, which enables determination of involved forces for each micropost.
