Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental DisordersElke Gabriel 1, Jay Gopalakrishnan 1,2
1Center for Molecular Medicine Cologne, University of Cologne, 2Institute for Biochemistry I, Medical School of University of Cologne
Modeling human brain development has been hindered due to the unprecedented complexity of neural epithelial tissue. Here, a method for the robust generation of brain organoids to delineate early events of human brain development and to model microcephaly in vitro is described.
