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Medical School of University of Cologne

1 ARTICLES PUBLISHED IN JoVE

Developmental Biology

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders

¹Center for Molecular Medicine Cologne, University of Cologne, ²Institute for Biochemistry I, Medical School of University of Cologne

Modeling human brain development has been hindered due to the unprecedented complexity of neural epithelial tissue. Here, a method for the robust generation of brain organoids to delineate early events of human brain development and to model microcephaly in vitro is described.