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Marshall University Joan C. Edwards School of Medicine

1 ARTICLES PUBLISHED IN JoVE

Biology

A Mouse 5/6^th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Xiaoliang Wang^*1, Muhammad A. Chaudhry^*2, Ying Nie², Zijian Xie¹, Joseph I. Shapiro², Jiang Liu^1,2

¹Marshall Institute for Interdisciplinary Research (MIIR), Marshall University, ²Department of Biomedical Sciences, Marshall University Joan C. Edwards School of Medicine

This manuscript provides a detailed two-step surgical procedure to perform mouse 5/6^th partial nephrectomy (PNx) with pole ligation. Four weeks after surgery, in comparison with sham-operated mice, the PNx mice developed impaired renal function, anemia, cardiac hypertrophy, cardiac fibrosis, and decreased heart systolic and diastolic function.