A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic CardiomyopathyXiaoliang Wang *1, Muhammad A. Chaudhry *2, Ying Nie 2, Zijian Xie 1, Joseph I. Shapiro 2, Jiang Liu 1,2
1Marshall Institute for Interdisciplinary Research (MIIR), Marshall University, 2Department of Biomedical Sciences, Marshall University Joan C. Edwards School of Medicine
This manuscript provides a detailed two-step surgical procedure to perform mouse 5/6th partial nephrectomy (PNx) with pole ligation. Four weeks after surgery, in comparison with sham-operated mice, the PNx mice developed impaired renal function, anemia, cardiac hypertrophy, cardiac fibrosis, and decreased heart systolic and diastolic function.
