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Rutgers Biomedical Health Sciences

1 ARTICLES PUBLISHED IN JoVE

Bioengineering

Multi-Stream Perfusion Bioreactor Integrated with Outlet Fractionation for Dynamic Cell Culture

Patrick Erickson¹, Aneesha Doshi², Gunjan Jetley², Param Amin², Aamena Mejevdiwala², Ashna Patel², Raphaela Bento², Biju Parekkadan^2,3

¹Department of Chemical and Biochemical Engineering, Rutgers University, ²Department of Biomedical Engineering, Rutgers University, ³Department of Medicine, Rutgers Biomedical Health Sciences

This paper presents a method to construct and operate a low-cost, multichannel perfusion cell culture system for measuring the dynamics of secretion and absorption rates of solutes in cellular processes. The system can also expose cells to dynamic stimulus profiles.