Name: Author Spotlight: Cutting-Edge Robotic Heller Myotomy Protocol for Treatment of Achalasia
Uploaded: 2024-02-16T14:20:00
Description: Read this Scientific Article Protocol about Author Spotlight: Cutting-Edge Robotic Heller Myotomy Protocol for Treatment of Achalasia at JoVE.com

I would like to express my sincere gratitude to Dr. DuCoin for the opportunity to study robotic foregut surgery. As a research fellow from Israel, I am grateful for the opportunity to share this robotic approach to the Heller myotomy used at our center. The authors received no funding for this work.

This protocol follows the guidelines of our institution&#39;s human research ethics committee. Written informed consent was obtained from the patients&#39; cases reviewed for the protocol. Inclusion criteria - patients of all ages who were diagnosed with achalasia based on clinical manifestations, manometric criteria, and radiographic studies. Exclusion criteria - achalasia symptoms due to gastroesophageal malignancy.
1. Preoperative preparation
<ol>
	<li>Place patients on a...

Treatment of Achalasia by Robot-Assisted Heller Myotomy

<ol>
	<li>Boeckxstaens, G. E., Zaninotto, G., Richter, J. E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Achalasia.">Achalasia.</a> Lancet. 383, 83-93 (2014).</li><li>Goyal, R. K., Chaudhury, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Pathogenesis+of+achalasia:+lessons+from+mutant+mice.">Pathogenesis of achalasia: lessons from mutant mice.</a> Gastroenterology. 39 (4), 1086-1090 (2010).</li><li>Leeuwenburgh, I., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Long-term+esophageal+cancer+risk+in+patients+with+primary+achalasia:+a+prospective+study.">Long-term esophageal cancer risk in patients with primary achalasia: a prospective study.</a> Am J Gastroenterol. 105 (10), 2144-2149 (2010).</li><li>Campos, G. M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Endoscopic+and+surgical+treatments+for+achalasia:+a+systematic+review+and+meta-analysis.">Endoscopic and surgical treatments for achalasia: a systematic review and meta-analysis.</a> Ann Surg. 249 (1), 45-57 (2009).</li><li>Lopushinsky, S. R., Urbach, D. R. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Pneumatic+dilatation+and+surgical+myotomy+for+achalasia.">Pneumatic dilatation and surgical myotomy for achalasia.</a> JAMA. 296 (18), 2227-2233 (2006).</li><li>Yaghoobi, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Laparoscopic+Heller's+myotomy+versus+pneumatic+dilation+in+the+treatment+of+idiopathic+achalasia:+a+meta-analysis+of+randomized,+controlled+trials.">Laparoscopic Heller's myotomy versus pneumatic dilation in the treatment of idiopathic achalasia: a meta-analysis of randomized, controlled trials.</a> Gastrointest Endosc. 78 (3), 468-475 (2013).</li><li>Boeckxstaens, G. E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Pneumatic+dilation+versus+laparoscopic+Heller's+myotomy+for+idiopathic+achalasia.">Pneumatic dilation versus laparoscopic Heller's myotomy for idiopathic achalasia.</a> N Engl J Med. 364 (19), 1807-1816 (2011).</li><li>Patti, M. G., Schlottmann, F., Herbella, F. A. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Laparoscopic+Heller+myotomy+and+robotic+Heller+myotomy:+when+is+it+indicated.+Mini-invasive.">Laparoscopic Heller myotomy and robotic Heller myotomy: when is it indicated. Mini-invasive.</a> Surgery. 6, 38 (2022).</li><li>Campos, G. M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Endoscopic+and+surgical+treatments+for+achalasia:+a+systematic+review+and+meta-analysis.">Endoscopic and surgical treatments for achalasia: a systematic review and meta-analysis.</a> Ann Surg. 249 (1), 45-57 (2009).</li><li>Maeso, S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Efficacy+of+the+Da+Vinci+surgical+system+in+abdominal+surgery+compared+with+that+of+laparoscopy:+a+systematic+review+and+meta-analysis.">Efficacy of the Da Vinci surgical system in abdominal surgery compared with that of laparoscopy: a systematic review and meta-analysis.</a> Ann Surg. 252 (2), 254-262 (2010).</li><li>Huffmanm, L. C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Robotic+Heller+myotomy:+a+safe+operation+with+higher+postoperative+quality-of-life+indices.">Robotic Heller myotomy: a safe operation with higher postoperative quality-of-life indices.</a> Surgery. 142 (4), 613-618 (2007).</li></ol>

Laparoscopic and robotic Heller myotomy is now the procedure of choice with or without fundoplication6. The primary contentious issues revolve around the necessity of fundoplication after Heller myotomy, as well as the type of fundoplication (Toupet, Dor, Nissen) to minimize GERD. Peroral endoscopic myotomy (POEM) is another option for achalasia treatment; however, this option lacks a fundoplication procedure8. Therefore, surgeons should make decisions regarding which proce...

Achalasia is an esophageal motility disorder. The most common cause of achalasia is idiopathic, characterized by impairment of the circular and longitudinal muscular layers of the esophagus due to the destruction of the myenteric nerves in the lower esophageal sphincter (LES)1. This leads to the inability of the LES to relax. Achalasia is also associated with an increased risk of esophageal squamous cell carcinoma. The gold standard for diagnosing achalasia is manometry2,3. However, endoscopy should be performed to rule out other causes of narrowing, such as gastro esophageal junction (GEJ) malignancy and other strictures.
The treatment of achalasia is divided into surgical and non-surgical options. Non-surgical treatments include the use of drugs such as calcium channel blockers and nitrates, as well as endoscopic treatments like dilation or botulinum toxin injection. Non-surgical treatments have high recurrence rates4,5. Surgical treatment, specifically laparoscopic or robotic myotomy, originally described as the heller myotomy, can be performed with or without an anti-reflux procedure. Surgical treatment provides the best long-term treatment and relieves achalasia symptoms by dissection of the muscles in the affected part of the esophagus around the LES6.
The decision to perform a fundoplication following Heller myotomy remains controversial. In theory, anti-reflux procedures, such as the Dor or Toupet procedures, reduce the risk of gastroesophageal reflux disease (GERD) following myotomy. Peroral endoscopic myotomy (POEM) has been developed as an option in the treatment of achalasia. Through a proximal submucosal tunnel, the muscular layer of the affected esophagus is divided distally to the level of LES and cardia7. We perform the Heller myotomy using a robotic approach. The robotic platform offers enhanced high-definition visualization of distal esophageal and hiatal anatomy, advanced range of motion, and decreased complication rates when compared to the laparoscopic approach8. Despite all the advantages of the robotic approach, the method and approach to surgical treatment of achalasia decision ultimately lies with the surgeon and is dependent on the available resources, level of comfort, and experience with the available techniques. The goal of this protocol is to serve as a guide and a valuable resource for training new foregut surgeons, as well as residents, making the steps of the surgery clear and understandable.

<table border="1" fo:keep-together.within-page="1" fo:keep-with-next.within-page="always">
	<tbody>
		<tr>
			<td>8 mm assistance port</td>
			<td>Da Vinci</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Air Seal insuflation system</td>
			<td>CONMED</td>
			<td>Ias8-120LP</td>
			<td></td>
		</tr>
		<tr>
			<td>Force bipolar grasper</td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Forceps</td>
			<td></td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Four 8-mm robotic ports</td>
			<td>Da Vinci</td>
			<td></td>
			<td></td>
		</tr>
		<tr>
			<td>Hook cautery.&#160;</td>
			<td>COVIDIEN</td>
			<td>E3773-36C</td>
			<td></td>
		</tr>
		<tr>
			<td>Nathanson liver retractor</td>
			<td>Mediflex</td>
			<td>69704-3</td>
			<td></td>
		</tr>
		<tr>
			<td>Needle driver</td>
			<td>COVIDIEN</td>
			<td>172015</td>
			<td></td>
		</tr>
		<tr>
			<td>Robotic 30&#176; endoscope</td>
			<td>Da Vinci</td>
			<td>470057</td>
			<td></td>
		</tr>
		<tr>
			<td>Robotic advanced bipolar device (Vessel Sealer)</td>
			<td>INTUITIVE SURGICAL</td>
			<td>480422</td>
			<td></td>
		</tr>
		<tr>
			<td>Two laparoscopic graspers</td>
			<td>Stortv</td>
			<td></td>
			<td></td>
		</tr>
	</tbody>
</table>

robotic heller myotomy for advancements in surgical management of achalasia

Achalasia is an esophageal motility disorder. It occurs due to the destruction of nerves in the lower esophageal sphincter (LES), which leads to the failure of the LES to relax. Patients typically complain of dysphagia, chest pain, and regurgitation. They often report drinking liquids with solids intake to help propel food boluses into the stomach. The diagnosis of achalasia is typically confirmed with an esophagogram and a motility study (esophageal manometry). An esophagogram classically shows the bird beak sign with tapering in the distal esophagus. The treatment for achalasia includes both surgical and non-surgical options. Surgical treatment is associated with a lower rate of recurrences, high clinical success rate, and durability of symptom relief. The current gold standard of surgical technique is myotomy, or the dividing of the muscle fibers of the distal esophagus. Surgical myotomy can be accomplished via a laparoscopic or robotic technique; per-oral endoscopic myotomy is a new alternative intervention. Due to the theoretical risk of gastroesophageal reflux following a myotomy, an antireflux procedure is sometimes performed. We reviewed the approach to a robotic heller myotomy for the treatment of achalasia.

Author Spotlight: Cutting-Edge Robotic Heller Myotomy Protocol for Treatment of Achalasia

Robotic Heller Myotomy for Advancements in Surgical Management of Achalasia

The goal of protocol is really to standardize an approach to a very complex operation. Provide a valuable resource for other surgeons and surgical learners to have a really step-by-step method to perform the operation in a safe and efficient manner that leads to the highest quality outcome. The treatment of achalasia, there's multiple means, but the most robust and durable is what's called a Heller myotomy.And there's two different ways you can perform that. One is laparoscopically, which is kind of the older way, and the newer, more modern is with robotic surgery. With this protocol, we really dive deep into the robotic treatment of achalasia with a Heller myotomy, showing its advantages over a laparoscopic approach.It's complex, but the protocol simplifies it and makes it more durable and shows great value. So we have a large research institute, and we're continuously going to study achalasia and its treatment options. With this new protocol we will continue to study it, really looking for the durability and the long lasting nature of the myotomy and the various ways to approach it.We'll look for other options, but yes, we're gonna continue to study this, hopefully collaborate with other research institutes to get more patients, better outcomes, and dive deeper into the data. So the advantage of the protocol with the robotic platform, one, is its standardization. So now we finally have really well described easy to follow steps to the operation.And then with the robotic platform, with the dexterity of the instruments, the articulation, the ability to move and really find spaces, it's really like microscopic surgery. Compounding that with a three-dimensional view, it's far superior to laparoscopy, and we've showed improved outcomes within the operating room, decreased risk of complications. Now we just need to study that and see if it's a better definitive treatment for achalasia as well.We know it's better in the OR, we think it's gonna be better long-term as well. Yeah, so we will need to continuously question and study achalasia. Right now, there is no cure for the disease.All of the treatment options really are just treating the symptoms, doing that myotomy, releasing the muscle, making it easier for people to eat and swallow. But really we need to study the durability. We wanna dive deep into the questions and answer what is the most durable?What process or treatment is gonna lead to the longest lasting outcomes? So we can treat you once and have that last the rest of your life. Our belief is this protocol with the robotic platform is just that, but we'll continuously study this.

At our academic tertiary care center, both intraoperative and postoperative complications of Heller myotomy are extremely rare. Between 2020 and August 2023, post-Heller myotomy perforation rate was 0% utilizing the robotic approach. During this period, we performed 105 robotic Heller myotomy. Blood loss is generally less than 20 mL, and we did not transfuse blood for any patient; hospital stay length rarely exceeds postoperative day 1, and patients are able to drink immediately after surgery, experiencing relief of thei...

Read this Scientific Article Protocol about Author Spotlight: Cutting-Edge Robotic Heller Myotomy Protocol for Treatment of Achalasia at JoVE.com

The protocol presents a robotic approach to Heller myotomy for the treatment of achalasia.

Achalasia is an esophageal motility disorder. It occurs due to the destruction of nerves in the lower esophageal sphincter (LES), which leads to the ...