Hsing-Jien Kung

Identification of the bZIP and Rta homologues in the genome of rhesus monkey rhadinovirus.

Expression profile of tyrosine kinases in breast cancer.

Functional analysis of 44 mutant androgen receptors from human prostate cancer.

Identification of human male germ cell-associated kinase, a kinase transcriptionally activated by androgen in prostate cancer cells.

Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis.

Elevated C-met in thymic dendritic cells of New Zealand Black mice.

Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell line.

Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosourea.

Kaposi's sarcoma-associated herpesvirus K-bZIP is a coregulator of K-Rta: physical association and promoter-dependent transcriptional repression.

Androgen-induced recruitment of RNA polymerase II to a nuclear receptor-p160 coactivator complex.

K-bZIP of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) binds KSHV/HHV-8 Rta and represses Rta-mediated transactivation.

Elevated expression of tyrosine kinase DDR2 in primary biliary cirrhosis.

Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and induction of G1 growth arrest.

Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38.

Poly(ADP-ribose) polymerase 1 and Ste20-like kinase hKFC act as transcriptional repressors for gamma-2 herpesvirus lytic replication.

Characterization of the chromosomal binding sites and dimerization partners of the viral oncoprotein Meq in Marek's disease virus-transformed T cells.

The role of tyrosine kinase Etk/Bmx in EGF-induced apoptosis of MDA-MB-468 breast cancer cells.

The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation.

Interleukin-8 confers androgen-independent growth and migration of LNCaP: differential effects of tyrosine kinases Src and FAK.

Pentameric procyanidins isolated from Theobroma cacao seeds selectively downregulate ErbB2 in human aortic endothelial cells.

Marek's disease virus-encoded vIL-8 gene is involved in early cytolytic infection but dispensable for establishment of latency.

Molecular alterations associated with LNCaP cell progression to androgen independence.

ORF36 protein kinase of Kaposi's sarcoma herpesvirus activates the c-Jun N-terminal kinase signaling pathway.

Marek's disease virus-encoded Meq gene is involved in transformation of lymphocytes but is dispensable for replication.

Cocoa procyanidins inhibit proliferation and angiogenic signals in human dermal microvascular endothelial cells following stimulation by low-level H2O2.

Bi-directional regulation between tyrosine kinase Etk/BMX and tumor suppressor p53 in response to DNA damage.

Signal pathways in up-regulation of chemokines by tyrosine kinase MER/NYK in prostate cancer cells.

Negative modulation of androgen receptor transcriptional activity by Daxx.

Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells.

vLIP, a viral lipase homologue, is a virulence factor of Marek's disease virus.

c-Jun controls the efficiency of MAP kinase signaling by transcriptional repression of MAP kinase phosphatases.

Kaposi's sarcoma-associated herpesvirus K-bZIP represses gene transcription via SUMO modification.

Profiling of gene expression changes caused by p53 gain-of-function mutant alleles in prostate cancer cells.

Marek's disease virus Meq transforms chicken cells via the v-Jun transcriptional cascade: a converging transforming pathway for avian oncoviruses.

Multiplex analysis of intracellular signaling pathways in lymphoid cells by microbead suspension arrays.

Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse.

ACTR/AIB1/SRC-3 and androgen receptor control prostate cancer cell proliferation and tumor growth through direct control of cell cycle genes.

Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells.

Inappropriate activation of the androgen receptor by nonsteroids: involvement of the Src kinase pathway and its therapeutic implications.

Kaposi's sarcoma-associated herpesvirus-encoded protein kinase and its interaction with K-bZIP.

Proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor enhances androgen receptor functions through LIM-only coactivator, four-and-a-half LIM-only protein 2.

The oncogenic potential of a prostate cancer-derived androgen receptor mutant.

Heptad repeats regulate protein phosphatase 2a recruitment to I-kappaB kinase gamma/NF-kappaB essential modulator and are targeted by human T-lymphotropic virus type 1 tax.

Nonreceptor tyrosine kinases in prostate cancer.

Evidence for calpain-mediated androgen receptor cleavage as a mechanism for androgen independence.

BCL-2 functions as an activator of the AKT signaling pathway in pancreatic cancer.

An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells.

Recombinant Marek's disease virus (MDV) lacking the Meq oncogene confers protection against challenge with a very virulent plus strain of MDV.

Regulation of Id1 expression by SRC: implications for targeting of the bone morphogenetic protein pathway in cancer.

Impairment of the DNA repair and growth arrest pathways by p53R2 silencing enhances DNA damage-induced apoptosis in a p53-dependent manner in prostate cancer cells.

Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase.

RNA editing of androgen receptor gene transcripts in prostate cancer cells.

Homodimerization of Marek's disease virus-encoded Meq protein is not sufficient for transformation of lymphocytes in chickens.

Oncogenic activation of androgen receptor.

Aberrant activation of androgen receptor in a new neuropeptide-autocrine model of androgen-insensitive prostate cancer.

Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis.

In vitro characterization of the Meq proteins of Marek's disease virus vaccine strain CVI988.

The Src inhibitor AZD0530 blocks invasion and may act as a radiosensitizer in lung cancer cells.

A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth.

NF-kappaB serves as a cellular sensor of Kaposi's sarcoma-associated herpesvirus latency and negatively regulates K-Rta by antagonizing the RBP-Jkappa coactivator.

A comprehensive analysis of recruitment and transactivation potential of K-Rta and K-bZIP during reactivation of Kaposi's sarcoma-associated herpesvirus.

ADI, autophagy and apoptosis: metabolic stress as a therapeutic option for prostate cancer.

Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer.

Kruppel-associated box domain-associated protein-1 as a latency regulator for Kaposi's sarcoma-associated herpesvirus and its modulation by the viral protein kinase.

Interleukin-6 regulates androgen synthesis in prostate cancer cells.

ERK regulates calpain 2-induced androgen receptor proteolysis in CWR22 relapsed prostate tumor cell lines.

Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a SUMO E3 ligase that is SIM-dependent and SUMO-2/3-specific.

Microbead arrays for the analysis of ErbB receptor tyrosine kinase activation and dimerization in breast cancer cells.

Both homo and heterodimers of Marek's disease virus encoded Meq protein contribute to transformation of lymphocytes in chickens.

Aberrant activation of the androgen receptor by NF-kappaB2/p52 in prostate cancer cells.

KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation.

Multiplex analysis of Src family kinase signaling by microbead suspension arrays.

Effect of the specific Src family kinase inhibitor saracatinib on osteolytic lesions using the PC-3 bone model.

Genome-wide analysis of androgen receptor binding and gene regulation in two CWR22-derived prostate cancer cell lines.

Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors.

miR-125b promotes growth of prostate cancer xenograft tumor through targeting pro-apoptotic genes.

Histone demethylase JMJD2A regulates Kaposi's sarcoma-associated herpesvirus replication and is targeted by a viral transcriptional factor.

Targeting tyrosine kinases and autophagy in prostate cancer.

Novel flavonoids with antiproliferative activities against breast cancer cells.

Recombinant origin of the retrovirus XMRV.

Simultaneous targeting of Src kinase and receptor tyrosine kinase results in synergistic inhibition of renal cell carcinoma proliferation and migration.

Ligand-independent activation of the arylhydrocarbon receptor by ETK (Bmx) tyrosine kinase helps MCF10AT1 breast cancer cells to survive in an apoptosis-inducing environment.

Statins and prostate cancer: role of cholesterol inhibition vs. prevention of small GTP-binding proteins.

MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells.

Protein arginine methyltransferase 1-directed methylation of Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen.

ASC-J9 suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors.

MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth.

Histone methyltransferase NSD2/MMSET mediates constitutive NF-κB signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop.

Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs.

Guidelines for the use and interpretation of assays for monitoring autophagy.

Enhancing the effectiveness of androgen deprivation in prostate cancer by inducing Filamin A nuclear localization.

Modeling truncated AR expression in a natural androgen responsive environment and identification of RHOB as a direct transcriptional target.

Genotyping and genomic profiling of non-small-cell lung cancer: implications for current and future therapies.

Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Latency Associated Nuclear Antigen Regulates KSHV Epigenome by Association with Histone Demethylase, KDM3A.

Oncomir miR-125b Suppresses p14(ARF) to Modulate p53-Dependent and p53-Independent Apoptosis in Prostate Cancer.

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy.

SUMO and KSHV Replication.

Non-Coding RNAs in Castration-Resistant Prostate Cancer: Regulation of Androgen Receptor Signaling and Cancer Metabolism.

KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis.