Division of Endocrinology
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Temporal activation of p42/44 mitogen-activated protein kinase and c-Jun N-terminal kinase by acetaldehyde in rat hepatocytes and its loss after chronic ethanol exposure.
The Journal of pharmacology and experimental therapeutics Jun, 2002 | Pubmed ID: 12023518
Phosphotidylethanol mimics ethanol modulation of p42/44 mitogen-activated protein kinase signalling in hepatocytes.
Alcohol and alcoholism (Oxford, Oxfordshire) Nov-Dec, 2002 | Pubmed ID: 12414543
MAP kinase signaling in diverse effects of ethanol.
Life sciences Mar, 2004 | Pubmed ID: 15027449
Role of Ras in ethanol modulation of angiotensin II activated p42/p44 MAP kinase in rat hepatocytes.
Life sciences Nov, 2006 | Pubmed ID: 16950409
Epigenetic effects of ethanol on liver and gastrointestinal injury.
World journal of gastroenterology Sep, 2006 | Pubmed ID: 16981253
Acetaldehyde alters MAP kinase signalling and epigenetic histone modifications in hepatocytes.
Novartis Foundation symposium , 2007 | Pubmed ID: 17590997
Ethanol inhibition of angiotensin II-stimulated Tyr705 and Ser727 STAT3 phosphorylation in cultured rat hepatocytes: relevance to activation of p42/44 mitogen-activated protein kinase.
Alcohol (Fayetteville, N.Y.) Aug, 2008 | Pubmed ID: 18411006
Activation of MEK 1/2 and p42/44 MAPK by angiotensin II in hepatocyte nucleus and their potentiation by ethanol.
Alcohol (Fayetteville, N.Y.) Jun, 2009 | Pubmed ID: 19560630
Differential changes in MAP kinases, histone modifications, and liver injury in rats acutely treated with ethanol.
Alcoholism, clinical and experimental research Sep, 2010 | Pubmed ID: 20586759
Elevated activation of ERK1 and ERK2 accompany enhanced liver injury following alcohol binge in chronically ethanol-fed rats.
Alcoholism, clinical and experimental research Dec, 2011 | Pubmed ID: 21790671
Binge ethanol intake in chronically exposed rat liver decreases LDL-receptor and increases angiotensinogen gene expression.
World journal of hepatology Sep, 2011 | Pubmed ID: 21969878
Cardiac insulin resistance and microRNA modulators.
Experimental diabetes research , 2012 | Pubmed ID: 21977024
Histone H3 phosphorylation (Ser10, Ser28) and phosphoacetylation (K9S10) are differentially associated with gene expression in liver of rats treated in vivo with acute ethanol.
The Journal of pharmacology and experimental therapeutics Feb, 2012 | Pubmed ID: 22025646
Dysregulated phosphorylation and nuclear translocation of cyclic AMP response element binding protein (CREB) in rat liver after chronic ethanol binge.
European journal of pharmacology Mar, 2012 | Pubmed ID: 22269225
A proteomic analysis of liver after ethanol binge in chronically ethanol treated rats.
Proteome science , 2012 | Pubmed ID: 22545783
Mitochondria and Oxidative Stress in the Cardiorenal Metabolic Syndrome.
Cardiorenal medicine May, 2012 | Pubmed ID: 22619657
Insulin resistance and heart failure: molecular mechanisms.
Heart failure clinics Oct, 2012 | Pubmed ID: 22999243
Obesity-Related Alterations in Cardiac Lipid Profile and Nondipping Blood Pressure Pattern during Transition to Diastolic Dysfunction in Male db/db Mice.
Endocrinology Nov, 2012 | Pubmed ID: 23142808
Molecular and metabolic mechanisms of cardiac dysfunction in diabetes.
Life sciences Mar, 2013 | Pubmed ID: 23147391
Dipeptidylpeptidase inhibition is associated with improvement in blood pressure and diastolic function in insulin-resistant male Zucker obese rats.
Endocrinology Jul, 2013 | Pubmed ID: 23653460
Obesity and insulin resistance induce early development of diastolic dysfunction in young female mice fed a Western diet.
Endocrinology Oct, 2013 | Pubmed ID: 23885014
The Novel Angiotensin II Receptor Blocker Azilsartan Medoxomil Ameliorates Insulin Resistance Induced by Chronic Angiotensin II Treatment in Rat Skeletal Muscle.
Cardiorenal medicine Jul, 2013 | Pubmed ID: 23922555
Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance.
Metabolism: clinical and experimental Nov, 2013 | Pubmed ID: 23932846
DPP-4 Inhibitors as Therapeutic Modulators of Immune Cell Function and Associated Cardiovascular and Renal Insulin Resistance in Obesity and Diabetes.
Cardiorenal medicine Apr, 2013 | Pubmed ID: 23946724
Salt loading exacerbates diastolic dysfunction and cardiac remodeling in young female Ren2 rats.
Metabolism: clinical and experimental Dec, 2013 | Pubmed ID: 24075738
The role of tissue Renin-Angiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness.
Frontiers in endocrinology , 2013 | Pubmed ID: 24194732
Uric Acid - key ingredient in the recipe for cardiorenal metabolic syndrome.
Cardiorenal medicine Oct, 2013 | Pubmed ID: 24454316
Tissue-specific expression of GLP1R in mice: is the problem of antibody nonspecificity solved?
Diabetes Apr, 2014 | Pubmed ID: 24651800
Prevention of obesity-induced renal injury in male mice by DPP4 inhibition.
Endocrinology Jun, 2014 | Pubmed ID: 24712875
The pathophysiology of hypertension in patients with obesity.
Nature reviews. Endocrinology Jun, 2014 | Pubmed ID: 24732974
Fructose and uric acid: is there a role in endothelial function?
Current hypertension reports Jun, 2014 | Pubmed ID: 24760443
Arterial Stiffness: A Nexus between Cardiac and Renal Disease.
Cardiorenal medicine Apr, 2014 | Pubmed ID: 24847335
Pleiotropic effects of the dipeptidylpeptidase-4 inhibitors on the cardiovascular system.
American journal of physiology. Heart and circulatory physiology Aug, 2014 | Pubmed ID: 24929856
Dipeptidyl peptidase inhibition prevents diastolic dysfunction and reduces myocardial fibrosis in a mouse model of Western diet induced obesity.
Metabolism: clinical and experimental Aug, 2014 | Pubmed ID: 24933400
Oxidative stress and obesity: the chicken or the egg?
Diabetes Jul, 2014 | Pubmed ID: 24962921
DPP4 inhibition attenuates filtration barrier injury and oxidant stress in the zucker obese rat.
Obesity (Silver Spring, Md.) Oct, 2014 | Pubmed ID: 24995775
Estrogen and mitochondria function in cardiorenal metabolic syndrome.
Progress in molecular biology and translational science , 2014 | Pubmed ID: 25149220
Overnutrition, mTOR signaling, and cardiovascular diseases.
American journal of physiology. Regulatory, integrative and comparative physiology Nov, 2014 | Pubmed ID: 25253086
Uric acid promotes left ventricular diastolic dysfunction in mice fed a Western diet.
Hypertension (Dallas, Tex. : 1979) Mar, 2015 | Pubmed ID: 25489061
Mitochondrial functional impairment in response to environmental toxins in the cardiorenal metabolic syndrome.
Archives of toxicology Feb, 2015 | Pubmed ID: 25559775
Dipeptidyl peptidase-4 inhibition ameliorates Western diet-induced hepatic steatosis and insulin resistance through hepatic lipid remodeling and modulation of hepatic mitochondrial function.
Diabetes Jun, 2015 | Pubmed ID: 25605806
Mineralocorticoid receptor antagonism treats obesity-associated cardiac diastolic dysfunction.
Hypertension (Dallas, Tex. : 1979) May, 2015 | Pubmed ID: 25712719
Mineralocorticoid receptor blockade prevents Western diet-induced diastolic dysfunction in female mice.
American journal of physiology. Heart and circulatory physiology May, 2015 | Pubmed ID: 25747754
Low-Dose Mineralocorticoid Receptor Blockade Prevents Western Diet-Induced Arterial Stiffening in Female Mice.
Hypertension (Dallas, Tex. : 1979) Jul, 2015 | Pubmed ID: 26015449
Epigenetic histone modifications in a clinically relevant rat model of chronic ethanol-binge-mediated liver injury.
Hepatology international Sep, 2014 | Pubmed ID: 26201320
Erratum to: Epigenetic histone modifications in a clinically relevant rat model of chronic ethanol-binge-mediated liver injury.
Hepatology international Sep, 2014 | Pubmed ID: 26201321
Vascular stiffness in insulin resistance and obesity.
Frontiers in physiology , 2015 | Pubmed ID: 26321962
Endothelial Mineralocorticoid Receptor Deletion Prevents Diet-Induced Cardiac Diastolic Dysfunction in Females.
Hypertension (Dallas, Tex. : 1979) Dec, 2015 | Pubmed ID: 26441470
In Vivo Acute on Chronic Ethanol Effects in Liver: A Mouse Model Exhibiting Exacerbated Injury, Altered Metabolic and Epigenetic Responses.
Biomolecules , 2015 | Pubmed ID: 26610587
Endothelial Estrogen Receptor-α Does Not Protect Against Vascular Stiffness Induced by Western Diet in Female Mice.
Endocrinology Apr, 2016 | Pubmed ID: 26872089
Endothelial Mineralocorticoid Receptor Mediates Diet-Induced Aortic Stiffness in Females.
Circulation research Mar, 2016 | Pubmed ID: 26879229
Angiotensin II Stimulation of DPP4 Activity Regulates Megalin in the Proximal Tubules.
International journal of molecular sciences , 2016 | Pubmed ID: 27213360
Glucagon-Like Peptide 1 Receptor Activation and Platelet Function: Beyond Glycemic Control.
Diabetes Jun, 2016 | Pubmed ID: 27222394
Dipeptidyl peptidase-4 inhibition with linagliptin prevents western diet-induced vascular abnormalities in female mice.
Cardiovascular diabetology , 2016 | Pubmed ID: 27391040
1Division of Nephrology, Department of Medicine, University of Missouri-Columbia and Harry S Truman Memorial Veteran's Hospital,
2Division of Biomedical Sciences, Department of Medicine, University of Missouri-Columbia and Harry S Truman Memorial Veteran's Hospital,
3Division of Endocrinology, Department of Medicine, University of Missouri-Columbia and Harry S Truman Memorial Veteran's Hospital
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