Laboratory of Molecular Virology,
School of Systems Biology,
Laboratory of Molecular Virology, School of Systems Biology
Dr. Kashanchi obtained his Ph.D. from Dr. Charles Wood, and trained under Dr. Susumu Tonegawa at MIT (Nobel Laureate 1987 for Physiology and Medicine). He is currently a Professor and Director at the George Mason University’s Laboratory of Molecular Virology. He has obtained more than $15.8 M in funding (NIH, DOD, DOE, and Keck) since his departure from NIH’s intramural program in 2000. He has published more than 218 peer-reviewed manuscripts (h index = 57) and served as an editorial board and reviewer for journals such as JBC, Retrovirology, J. Virol, Virology, NAR, 4 PLoS Journals, Cell, Molecular Cell, Nature Medicine, Nature communications, Scientific Report and Science Translational Medicine.
His lab focuses on understanding the mechanism of viral gene expression in human viruses and how the virus and the host control the dynamics of fundamental machineries needed for viral replication and/or host survival, including pathways that leads to transcription and chromatin remolding using in vitro reconstituted DNA/RNA elements. His lab has also contributed to general understanding of how these machineries are different in T-cells vs. myeloid cells. In recent years, his lab has additionally been focusing on exosomes secreted from HIV and HTLV infected cells, as well as 7 other RNA and DNA virus infections (through collaborations) and validation of data using in vitro functional analysis and humanized mouse models. Since 1999, Dr. Kashanchi has trained more than 23 postodcs, 29 Ph.D students and 57 MS and undergrad students. Many of these students have continued as postdocs, and obtained Tenure-track academic appointments. Finally, he is a regular NIH study section member and has served on 143 panels since 2000, where he chaired or co-chaired 17 panels.
Human T-lymphotropic virus type 1 transcription and chromatin-remodeling complexes.
Journal of virology May, 2010 | Pubmed ID: 20164218
Inhibition of human immunodeficiency virus type-1 by cdk inhibitors.
AIDS research and therapy , 2010 | Pubmed ID: 20334651
Absence of DICER in monocytes and its regulation by HIV-1.
The Journal of biological chemistry Oct, 2010 | Pubmed ID: 20584909
Transcription through the HIV-1 nucleosomes: effects of the PBAF complex in Tat activated transcription.
Virology Sep, 2010 | Pubmed ID: 20599239
The identification of unique serum proteins of HIV-1 latently infected long-term non-progressor patients.
AIDS research and therapy , 2010 | Pubmed ID: 20604950
Methylation of the tumor suppressor protein, BRCA1, influences its transcriptional cofactor function.
PloS one , 2010 | Pubmed ID: 20614009
microRNA machinery is an integral component of drug-induced transcription inhibition in HIV-1 infection.
Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research , 2010 | Pubmed ID: 20628499
Direct detection of diverse metabolic changes in virally transformed and tax-expressing cells by mass spectrometry.
PloS one , 2010 | Pubmed ID: 20830293
Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9.
Molecular pharmacology Jan, 2011 | Pubmed ID: 20956357
Erratum to: microRNA machinery is an integral component of drug-induced transcription inhibition in HIV-1 infection.
Journal of RNAi and gene silencing : an international journal of RNA and gene targeting research , 2010 | Pubmed ID: 20963190
Reverse-phase phosphoproteome analysis of signaling pathways induced by Rift valley fever virus in human small airway epithelial cells.
PloS one , 2010 | Pubmed ID: 21072193
Hepcidin induces HIV-1 transcription inhibited by ferroportin.
Retrovirology , 2010 | Pubmed ID: 21126372
Analysis of the roles of HIV-derived microRNAs.
Expert opinion on biological therapy Jan, 2011 | Pubmed ID: 21133815
Developments in antivirals against influenza, smallpox and hemorrhagic fever viruses.
Expert opinion on investigational drugs Feb, 2011 | Pubmed ID: 21235430
Secreted Bacillus anthracis proteases target the host fibrinolytic system.
FEMS immunology and medical microbiology Jul, 2011 | Pubmed ID: 21395696
Bacillus anthracis interacts with plasmin(ogen) to evade C3b-dependent innate immunity.
PloS one , 2011 | Pubmed ID: 21464960
Inhibition of Tat-mediated HIV-1 replication and neurotoxicity by novel GSK3-beta inhibitors.
Virology Jun, 2011 | Pubmed ID: 21514616
Alteration in superoxide dismutase 1 causes oxidative stress and p38 MAPK activation following RVFV infection.
PloS one , 2011 | Pubmed ID: 21655261
Targeting the inflammasome and adenosine type-3 receptors improves outcome of antibiotic therapy in murine anthrax.
World journal of biological chemistry May, 2011 | Pubmed ID: 21666812
Varying modulation of HIV-1 LTR activity by Baf complexes.
Journal of molecular biology Aug, 2011 | Pubmed ID: 21699904
Role of β-catenin and TCF/LEF family members in transcriptional activity of HIV in astrocytes.
Journal of virology Feb, 2012 | Pubmed ID: 22156527
Humanized mouse models of HIV-1 latency.
Current HIV research Dec, 2011 | Pubmed ID: 22211664
Induction of DNA damage signaling upon Rift Valley fever virus infection results in cell cycle arrest and increased viral replication.
The Journal of biological chemistry Mar, 2012 | Pubmed ID: 22223653
Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection.
Biochemical and biophysical research communications Mar, 2012 | Pubmed ID: 22326260
New and novel intrinsic host repressive factors against HIV-1: PAF1 complex, HERC5 and others.
Retrovirology Mar, 2012 | Pubmed ID: 22405323
Bacillus anthracis protease InhA regulates BslA-mediated adhesion in human endothelial cells.
Cellular microbiology Aug, 2012 | Pubmed ID: 22452315
Modulation of GSK-3β activity in Venezuelan equine encephalitis virus infection.
PloS one , 2012 | Pubmed ID: 22496857
p53 Activation following Rift Valley fever virus infection contributes to cell death and viral production.
PloS one , 2012 | Pubmed ID: 22574148
Identification of novel T cell factor 4 (TCF-4) binding sites on the HIV long terminal repeat which associate with TCF-4, β-catenin, and SMAR1 to repress HIV transcription.
Journal of virology Sep, 2012 | Pubmed ID: 22674979
Use of ATP analogs to inhibit HIV-1 transcription.
Virology Oct, 2012 | Pubmed ID: 22771113
Localization and sub-cellular shuttling of HTLV-1 tax with the miRNA machinery.
PloS one , 2012 | Pubmed ID: 22808228
Enduring cortical alterations after a single in-vivo treatment of HIV-1 Tat.
Neuroreport Oct, 2012 | Pubmed ID: 22828409
Curcumin inhibits Rift Valley fever virus replication in human cells.
The Journal of biological chemistry Sep, 2012 | Pubmed ID: 22847000
In vivo murine and in vitro M-like cell models of gastrointestinal anthrax.
Microbes and infection Jan, 2013 | Pubmed ID: 23108317
CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90.
Retrovirology Nov, 2012 | Pubmed ID: 23140174
Bacillus anthracis-derived nitric oxide induces protein S-nitrosylation contributing to macrophage death.
Biochemical and biophysical research communications Jan, 2013 | Pubmed ID: 23178574
HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathways.
Frontiers in microbiology , 2012 | Pubmed ID: 23226145
Effect of Mimetic CDK9 Inhibitors on HIV-1-Activated Transcription.
Journal of molecular biology Feb, 2013 | Pubmed ID: 23247501
Complex role of microRNAs in HTLV-1 infections.
Frontiers in genetics , 2012 | Pubmed ID: 23251140
Retrovirus infected cells contain viral microRNAs.
Retrovirology Feb, 2013 | Pubmed ID: 23391025
Exosomes derived from HIV-1-infected cells contain trans-activation response element RNA.
The Journal of biological chemistry Jul, 2013 | Pubmed ID: 23661700
The use of NanoTrap particles as a sample enrichment method to enhance the detection of Rift Valley Fever Virus.
PLoS neglected tropical diseases , 2013 | Pubmed ID: 23861988
Novel neuroprotective GSK-3β inhibitor restricts Tat-mediated HIV-1 replication.
Journal of virology Jan, 2014 | Pubmed ID: 24227837
Reactive oxygen species activate NFκB (p65) and p53 and induce apoptosis in RVFV infected liver cells.
Virology Jan, 2014 | Pubmed ID: 24418562
The carrying pigeons of the cell: exosomes and their role in infectious diseases caused by human pathogens.
Pathogens and disease Jul, 2014 | Pubmed ID: 24449527
Repeated cocaine treatment enhances HIV-1 Tat-induced cortical excitability via over-activation of L-type calcium channels.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology Jun, 2014 | Pubmed ID: 24567038
Exosomes and their role in CNS viral infections.
Journal of neurovirology Jun, 2014 | Pubmed ID: 24578033
The role of IKKβ in Venezuelan equine encephalitis virus infection.
PloS one , 2014 | Pubmed ID: 24586253
The use of Nanotrap particles technology in capturing HIV-1 virions and viral proteins from infected cells.
PloS one , 2014 | Pubmed ID: 24820173
Transcriptional Gene Silencing (TGS) via the RNAi Machinery in HIV-1 Infections.
Biology , 2012 | Pubmed ID: 24832229
Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain Tax protein.
The Journal of biological chemistry Aug, 2014 | Pubmed ID: 24939845
Phenyl-1-Pyridin-2yl-ethanone-based iron chelators increase IκB-α expression, modulate CDK2 and CDK9 activities, and inhibit HIV-1 transcription.
Antimicrobial agents and chemotherapy Nov, 2014 | Pubmed ID: 25155598
Break CDK2/Cyclin E1 interface allosterically with small peptides.
PloS one , 2014 | Pubmed ID: 25290691
Discovery and characterization of auxiliary proteins encoded by type 3 simian T-cell lymphotropic viruses.
Journal of virology Jan, 2015 | Pubmed ID: 25355890
Role of Bruton's tyrosine kinase inhibitors in HIV-1-infected cells.
Journal of neurovirology Jun, 2015 | Pubmed ID: 25672887
Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-κB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR.
Virology Sep, 2015 | Pubmed ID: 25980739
Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1.
Retrovirology Jul, 2015 | Pubmed ID: 26178009
Therapeutic doses of irradiation activate viral transcription and induce apoptosis in HIV-1 infected cells.
Virology Nov, 2015 | Pubmed ID: 26184775
Extracellular vesicles from infected cells: potential for direct pathogenesis.
Frontiers in microbiology , 2015 | Pubmed ID: 26539170
Exosomes from HIV-1-infected Cells Stimulate Production of Pro-inflammatory Cytokines through Trans-activating Response (TAR) RNA.
The Journal of biological chemistry Jan, 2016 | Pubmed ID: 26553869
Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary.
AIDS research and human retroviruses Feb, 2016 | Pubmed ID: 26670361
HIV-1 Nef blocks autophagy in human astrocytes.
Cell cycle (Georgetown, Tex.) , 2015 | Pubmed ID: 26697833
Potential of Radiation-Induced Cellular Stress for Reactivation of Latent HIV-1 and Killing of Infected Cells.
AIDS research and human retroviruses Feb, 2016 | Pubmed ID: 26765533
Presence of Viral RNA and Proteins in Exosomes from Cellular Clones Resistant to Rift Valley Fever Virus Infection.
Frontiers in microbiology , 2016 | Pubmed ID: 26904012
Zika Virus: A New Animal Model for an Arbovirus.
PLoS neglected tropical diseases 05, 2016 | Pubmed ID: 27149628
Exosomes in Viral Disease.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics Jul, 2016 | Pubmed ID: 27324390
Biodegradable Nanoparticles for Delivery of Therapeutics in CNS Infection.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 03, 2017 | Pubmed ID: 27372507
HIV Vpr controls CNS metabolism.
Cell cycle (Georgetown, Tex.) 09, 2016 | Pubmed ID: 27421087
Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction.
Frontiers in microbiology , 2016 | Pubmed ID: 27872619
The Role of Exosomal VP40 in Ebola Virus Disease.
DNA and cell biology Apr, 2017 | Pubmed ID: 28177658
The Human Immunodeficiency Virus 1 ASP RNA promotes viral latency by recruiting the Polycomb Repressor Complex 2 and promoting nucleosome assembly.
Virology 06, 2017 | Pubmed ID: 28340355
Isolation of Exosomes from HTLV-Infected Cells.
Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 28357662
Presence of Viral microRNA in Extracellular Environments.
EBioMedicine Jun, 2017 | Pubmed ID: 28495208
Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation.
Scientific reports 05, 2017 | Pubmed ID: 28500326
Exosomes from uninfected cells activate transcription of latent HIV-1.
The Journal of biological chemistry 07, 2017 | Pubmed ID: 28536264
HIV-1 Transcription Inhibitors Increase the Synthesis of Viral Non-Coding RNA that Contribute to Latency.
Current pharmaceutical design , 2017 | Pubmed ID: 28641535
Interplay between Autophagy, Exosomes and HIV-1 Associated Neurological Disorders: New Insights for Diagnosis and Therapeutic Applications.
Viruses 07, 2017 | Pubmed ID: 28684681
Importance of Autophagy in Mediating Human Immunodeficiency Virus (HIV) and Morphine-Induced Metabolic Dysfunction and Inflammation in Human Astrocytes.
Viruses 07, 2017 | Pubmed ID: 28788100
Proceedings of the ISEV symposium on "HIV, NeuroAIDS, drug abuse & EVs".
Journal of extracellular vesicles , 2017 | Pubmed ID: 28800366
Inhibition of HIV-1 infection in humanized mice and metabolic stability of protein phosphatase-1-targeting small molecule 1E7-03.
Oncotarget Sep, 2017 | Pubmed ID: 29100346
Proceedings of the 2017 ISEV symposium on "HIV, NeuroHIV, drug abuse, & EVs".
Journal of neurovirology Dec, 2017 | Pubmed ID: 29147885
Monocyte-derived exosomes upon exposure to cigarette smoke condensate alter their characteristics and show protective effect against cytotoxicity and HIV-1 replication.
Scientific reports 11, 2017 | Pubmed ID: 29170447
Author Correction: Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation.
Scientific reports Mar, 2018 | Pubmed ID: 29540788
Tat controls transcriptional persistence of unintegrated HIV genome in primary human macrophages.
Virology 05, 2018 | Pubmed ID: 29549786
Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop.
JCI insight Apr, 2018 | Pubmed ID: 29618663
Role of Exosomes in Human Retroviral Mediated Disorders.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 09, 2018 | Pubmed ID: 29656370
Corrigendum: Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction.
Frontiers in microbiology , 2018 | Pubmed ID: 29696006
Antiretroviral Drugs Alter the Content of Extracellular Vesicles from HIV-1-Infected Cells.
Scientific reports May, 2018 | Pubmed ID: 29769566
Viral antigens detectable in CSF exosomes from patients with retrovirus associated neurologic disease: functional role of exosomes.
Clinical and translational medicine Aug, 2018 | Pubmed ID: 30146667
Ebola Virus VP40 Modulates Cell Cycle and Biogenesis of Extracellular Vesicles.
The Journal of infectious diseases 11, 2018 | Pubmed ID: 30169850
Removal of HIV DNA by CRISPR from Patient Blood Engrafts in Humanized Mice.
Molecular therapy. Nucleic acids Sep, 2018 | Pubmed ID: 30195766
Publisher Correction: Antiretroviral Drugs Alter the Content of Extracellular Vesicles from HIV-1-Infected Cells.
Scientific reports Sep, 2018 | Pubmed ID: 30232388
Complementary Mechanisms Potentially Involved in the Pathology of Zika Virus.
Frontiers in immunology , 2018 | Pubmed ID: 30374352
Autophagy, EVs, and Infections: A Perfect Question for a Perfect Time.
Frontiers in cellular and infection microbiology , 2018 | Pubmed ID: 30406039
Toll-like receptor 3 regulates Zika virus infection and associated host inflammatory response in primary human astrocytes.
PloS one , 2019 | Pubmed ID: 30735502
Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone-modifying enzymes in HIV-infected astrocytes.
Journal of neurovirology Apr, 2019 | Pubmed ID: 30746609
Effect of transcription inhibition and generation of suppressive viral non-coding RNAs.
Retrovirology 04, 2019 | Pubmed ID: 31036006
Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion.
Viruses May, 2019 | Pubmed ID: 31052499
Stem Cell Extracellular Vesicles and their Potential to Contribute to the Repair of Damaged CNS Cells.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology Jul, 2019 | Pubmed ID: 31338754
An Omics Approach to Extracellular Vesicles from HIV-1 Infected Cells.
Cells Jul, 2019 | Pubmed ID: 31362387
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