Guri Giaever

Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents.

Systematic screen for human disease genes in yeast.

Functional profiling of the Saccharomyces cerevisiae genome.

"Chemogenomics: tools for protein families" and "Chemical genomics: chemical and biological integration".

A chemical genomics approach to understanding drug action.

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast.

Noise minimization in eukaryotic gene expression.

Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast.

Functional genomic analysis of the rates of protein evolution.

A latent variable model for chemogenomic profiling.

Genome-wide requirements for resistance to functionally distinct DNA-damaging agents.

A unique and universal molecular barcode array.

Experimental approaches to identify genetic networks.

Chemical genomic profiling for identifying intracellular targets of toxicants producing Parkinson's disease.

Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions.

Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay.

Identification of genes involved in the toxic response of Saccharomyces cerevisiae against iron and copper overload by parallel analysis of deletion mutants.

Examining protein protein interactions using endogenously tagged yeast arrays: the cross-and-capture system.

Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures.

Defining genetic interaction.

Chemical-genetic approaches for exploring the mode of action of natural products.

The chemical genomic portrait of yeast: uncovering a phenotype for all genes.

Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen.

The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast.

An integrated platform of genomic assays reveals small-molecule bioactivities.

Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers.

Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast.

Yeast chemical genomics and drug discovery: an update.

Combination chemical genetics.

Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells.

Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis.

Knocking sense into regulatory pathways.

Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis.

Novel insights into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiae.

Precise gene-dose alleles for chemical genetics.

A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds.

Chemogenomic approaches to elucidation of gene function and genetic pathways.

Quantitative phenotyping via deep barcode sequencing.

A comparative analysis of DNA barcode microarray feature size.

The genetic landscape of a cell.

Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action.

Genotype to phenotype: a complex problem.

Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples.

A universal TagModule collection for parallel genetic analysis of microorganisms.

A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans.

A survey of yeast genomic assays for drug and target discovery.

Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.

Exploring gene function and drug action using chemogenomic dosage assays.

Gene annotation and drug target discovery in Candida albicans with a tagged transposon mutant collection.

Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection.

Systematic exploration of essential yeast gene function with temperature-sensitive mutants.

The synthetic genetic interaction network reveals small molecules that target specific pathways in Sacchromyces cerevisiae.

A comprehensive platform for highly multiplexed mammalian functional genetic screens.

Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell.

Design, synthesis, and characterization of a highly effective Hog1 inhibitor: a powerful tool for analyzing MAP kinase signaling in yeast.

Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases.

New azole antifungal agents with novel modes of action: synthesis and biological studies of new tridentate ligands based on pyrazole and triazole.

The automated cell: compound and environment screening system (ACCESS) for chemogenomic screening.

Displaying chemical information on a biological network using Cytoscape.

Curcumin inhibits growth of Saccharomyces cerevisiae through iron chelation.

A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis.

Compound prioritization methods increase rates of chemical probe discovery in model organisms.

Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.

Systematic exploration of synergistic drug pairs.

Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia.

Multiple means to the same end: the genetic basis of acquired stress resistance in yeast.

Bugs, drugs and chemical genomics.

Mitochondrial electron transport is the cellular target of the oncology drug elesclomol.

Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.

A global perspective of the genetic basis for carbonyl stress resistance.

Identification of yeast genes that confer resistance to chitosan oligosaccharide (COS) using chemogenomics.

A novel calcineurin-independent activity of cyclosporin A in Saccharomyces cerevisiae.

Barcode sequencing for understanding drug-gene interactions.

Comparative chemogenomics to examine the mechanism of action of dna-targeted platinum-acridine anticancer agents.

Global gene deletion analysis exploring yeast filamentous growth.

An algorithm for chemical genomic profiling that minimizes batch effects: bucket evaluations.

Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae.

Functional analysis with a barcoder yeast gene overexpression system.

A phenotypic screening platform to identify small molecule modulators of Chlamydomonas reinhardtii growth, motility and photosynthesis.

Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors.

Chromatin is an ancient innovation conserved between Archaea and Eukarya.

Global analysis of SUMO chain function reveals multiple roles in chromatin regulation.

DNA-damaging agents in cancer chemotherapy: serendipity and chemical biology.

A high-throughput yeast assay identifies synergistic drug combinations.

Miniature short hairpin RNA screens to characterize antiproliferative drugs.

A novel small molecule methyltransferase is important for virulence in Candida albicans.

PITPs as targets for selectively interfering with phosphoinositide signaling in cells.

Large-scale identification and analysis of suppressive drug interactions.

Mapping the cellular response to small molecules using chemogenomic fitness signatures.

A genome scale overexpression screen to reveal drug activity in human cells.

Genes required for survival in microgravity revealed by genome-wide yeast deletion collections cultured during spaceflight.

Caenorhabditis elegans is a useful model for anthelmintic discovery.

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles.