Ian Goodfellow

Coxsackie B viruses that use human DAF as a receptor infect pig cells via pig CAR and do not use pig DAF.

Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A.

Coxsackievirus B3-associated myocardial pathology and viral load reduced by recombinant soluble human decay-accelerating factor in mice.

Structure and function analysis of the poliovirus cis-acting replication element (CRE).

Generation of anti-complement "prodrugs": cleavable reagents for specific delivery of complement regulators to disease sites.

The poliovirus 2C cis-acting replication element-mediated uridylylation of VPg is not required for synthesis of negative-sense genomes.

The structure of echovirus type 12 bound to a two-domain fragment of its cellular attachment protein decay-accelerating factor (CD 55).

Interactions of decay-accelerating factor (DAF) with haemagglutinating human enteroviruses: utilizing variation in primate DAF to map virus binding sites.

A chimeric N-terminal Escherichia coli--C-terminal Rhodobacter sphaeroides FliG rotor protein supports bidirectional E. coli flagellar rotation and chemotaxis.

Factors required for the Uridylylation of the foot-and-mouth disease virus 3B1, 3B2, and 3B3 peptides by the RNA-dependent RNA polymerase (3Dpol) in vitro.

Inhibition of coxsackie B virus infection by soluble forms of its receptors: binding affinities, altered particle formation, and competition with cellular receptors.

Calicivirus translation initiation requires an interaction between VPg and eIF 4 E.

Analysis of protein-protein interactions in the feline calicivirus replication complex.

Caliciviruses differ in their functional requirements for eIF4F components.

Role of RNA structure and RNA binding activity of foot-and-mouth disease virus 3C protein in VPg uridylylation and virus replication.

Feline calicivirus replication: requirement for polypyrimidine tract-binding protein is temperature-dependent.

Recovery of genetically defined murine norovirus in tissue culture by using a fowlpox virus expressing T7 RNA polymerase.

Structural insights into the transcriptional and translational roles of Ebp1.

Eukaryotic initiation factor 4E.

Bioinformatic and functional analysis of RNA secondary structure elements among different genera of human and animal caliciviruses.

Structural insights into calicivirus attachment and uncoating.

Picornavirus genome replication: roles of precursor proteins and rate-limiting steps in oriI-dependent VPg uridylylation.

Insight into poliovirus genome replication and encapsidation obtained from studies of 3B-3C cleavage site mutants.

Feline calicivirus p32, p39 and p30 proteins localize to the endoplasmic reticulum to initiate replication complex formation.

Functional analysis of RNA structures present at the 3' extremity of the murine norovirus genome: the variable polypyrimidine tract plays a role in viral virulence.

Polypyrimidine tract binding protein functions as a negative regulator of feline calicivirus translation.

Development of an optimized RNA-based murine norovirus reverse genetics system.

Functional impairment of eIF4A and eIF4G factors correlates with inhibition of influenza virus mRNA translation.

Nucleolin interacts with the feline calicivirus 3' untranslated region and the protease-polymerase NS6 and NS7 proteins, playing a role in virus replication.

The cryo-electron microscopy structure of feline calicivirus bound to junctional adhesion molecule A at 9-angstrom resolution reveals receptor-induced flexibility and two distinct conformational changes in the capsid protein VP1.

VPg-primed RNA synthesis of norovirus RNA-dependent RNA polymerases by using a novel cell-based assay.

Influenza virus polymerase confers independence of the cellular cap-binding factor eIF4E for viral mRNA translation.

Norovirus regulation of the innate immune response and apoptosis occurs via the product of the alternative open reading frame 4.

Norovirus RNA synthesis is modulated by an interaction between the viral RNA-dependent RNA polymerase and the major capsid protein, VP1.

High-resolution functional profiling of the norovirus genome.

Identification of RNA-protein interaction networks involved in the norovirus life cycle.

Structures of the Compact Helical Core Domains of Feline Calicivirus and Murine Norovirus VPg Proteins.

Influence of genome-scale RNA structure disruption on the replication of murine norovirus--similar replication kinetics in cell culture but attenuation of viral fitness in vivo.

Next-generation whole genome sequencing identifies the direction of norovirus transmission in linked patients.

Scaling up spike-and-slab models for unsupervised feature learning.

Norovirus genome circularization and efficient replication are facilitated by binding of PCBP2 and hnRNP A1.

Progress towards the prevention and treatment of norovirus infections.

Pathology caused by persistent murine norovirus infection.

Norovirus gene expression and replication.

Serological evidence for multiple strains of canine norovirus in the UK dog population.

Murine norovirus: propagation, quantification, and genetic manipulation.

Both α2,3- and α2,6-Linked Sialic Acids on O-Linked Glycoproteins Act as Functional Receptors for Porcine Sapovirus.

Advances in Norovirus Biology.

Norovirus translation requires an interaction between the C terminus of the genome-linked viral protein VPg and eukaryotic translation initiation factor 4G.

Detection of protein-protein interactions using tandem affinity purification.