Jack Greenblatt

COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression.

Evidence that the KH RNA-binding domains influence the action of the E. coli NusA protein.

Regulation of transcription elongation by phosphorylation.

RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach.

Bridging structural biology and genomics: assessing protein interaction data with known complexes.

Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter.

Solution structure of the carboxyl-terminal domain of RAP74 and NMR characterization of the FCP1-binding sites of RAP74 and human TFIIB.

Specific homeodomain-DNA interactions are required for HOX11-mediated transformation.

The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation.

NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1.

Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II.

Protein profiling with Epstein-Barr nuclear antigen-1 reveals an interaction with the herpesvirus-associated ubiquitin-specific protease HAUSP/USP7.

Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends.

A panoramic view of yeast noncoding RNA processing.

A Bayesian networks approach for predicting protein-protein interactions from genomic data.

A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1.

Purification and assay of Saccharomyces cerevisiae phosphatase that acts on the C-terminal domain of the largest subunit of RNA polymerase II.

The ctf13-30/CTF13 genomic haploinsufficiency modifier screen identifies the yeast chromatin remodeling complex RSC, which is required for the establishment of sister chromatid cohesion.

Transitions in RNA polymerase II elongation complexes at the 3' ends of genes.

High-definition macromolecular composition of yeast RNA-processing complexes.

Global mapping of the yeast genetic interaction network.

ESF1 is required for 18S rRNA synthesis in Saccharomyces cerevisiae.

Dephosphorylation of RNA polymerase I by Fcp1p is required for efficient rRNA synthesis.

Bromodomain factor 1 (Bdf1) is phosphorylated by protein kinase CK2.

Exploration of essential gene functions via titratable promoter alleles.

Sequential Peptide Affinity (SPA) system for the identification of mammalian and bacterial protein complexes.

RPAP1, a novel human RNA polymerase II-associated protein affinity purified with recombinant wild-type and mutated polymerase subunits.

Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4.

Interaction of Fcp1 phosphatase with elongating RNA polymerase II holoenzyme, enzymatic mechanism of action, and genetic interaction with elongator.

The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II.

A role for SlyD in the Escherichia coli hydrogenase biosynthetic pathway.

The functional landscape of mouse gene expression.

INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair.

Proteasome involvement in the repair of DNA double-strand breaks.

Histone H2B ubiquitylation is associated with elongating RNA polymerase II.

H2B ubiquitin protease Ubp8 and Sgf11 constitute a discrete functional module within the Saccharomyces cerevisiae SAGA complex.

Interaction network containing conserved and essential protein complexes in Escherichia coli.

The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism.

Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing.

Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1.

Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone.

The highly conserved glutamic acid 791 of Rpb2 is involved in the binding of NTP and Mg(B) in the active center of human RNA polymerase II.

Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction.

BUR kinase selectively regulates H3 K4 trimethylation and H2B ubiquitylation through recruitment of the PAF elongation complex.

Identification and characterization of Elf1, a conserved transcription elongation factor in Saccharomyces cerevisiae.

Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile.

Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.

A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery.

Formation of a distinctive complex between the inducible bacterial lysine decarboxylase and a novel AAA+ ATPase.

Interactions of the Escherichia coli hydrogenase biosynthetic proteins: HybG complex formation.

The Saccharomyces cerevisiae histone H2A variant Htz1 is acetylated by NuA4.

Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.

A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.

Systems-level analyses identify extensive coupling among gene expression machines.

PIPE: a protein-protein interaction prediction engine based on the re-occurring short polypeptide sequences between known interacting protein pairs.

Investigating the in vivo activity of the DeaD protein using protein-protein interactions and the translational activity of structured chloramphenicol acetyltransferase mRNAs.

The RNA polymerase II kinase Ctk1 regulates positioning of a 5' histone methylation boundary along genes.

Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae.

Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map.

Identifying functional modules in the physical interactome of Saccharomyces cerevisiae.

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

The minimum information required for reporting a molecular interaction experiment (MIMIx).

Genomic location of the human RNA polymerase II general machinery: evidence for a role of TFIIF and Rpb7 at both early and late stages of transcription.

Association with the origin recognition complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p.

Examining protein protein interactions using endogenously tagged yeast arrays: the cross-and-capture system.

Interacting proteins Rtt109 and Vps75 affect the efficiency of non-homologous end-joining in Saccharomyces cerevisiae.

Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex.

The Glc7 phosphatase subunit of the cleavage and polyadenylation factor is essential for transcription termination on snoRNA genes.

Transcription termination: pulling out all the stops.

Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109.

A histone code for chromatin assembly.

eSGA: E. coli synthetic genetic array analysis.

Biosynthesis of the respiratory formate dehydrogenases from Escherichia coli: characterization of the FdhE protein.

Local coherence in genetic interaction patterns reveals prevalent functional versatility.

Interaction of the deubiquitinating enzyme Ubp2 and the e3 ligase Rsp5 is required for transporter/receptor sorting in the multivesicular body pathway.

Stable complex formation between HIV Rev and the nucleosome assembly protein, NAP1, affects Rev function.

Control of transcriptional elongation and cotranscriptional histone modification by the yeast BUR kinase substrate Spt5.

Conserved network of proteins essential for bacterial viability.

Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins.

Systematic characterization of the protein interaction network and protein complexes in Saccharomyces cerevisiae using tandem affinity purification and mass spectrometry.

An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell.

Sequential peptide affinity purification system for the systematic isolation and identification of protein complexes from Escherichia coli.

Two-color cell array screen reveals interdependent roles for histone chaperones and a chromatin boundary regulator in histone gene repression.

Systems-level approaches for identifying and analyzing genetic interaction networks in Escherichia coli and extensions to other prokaryotes.

A systematic characterization of Cwc21, the yeast ortholog of the human spliceosomal protein SRm300.

An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe.

A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.

The evolutionary landscape of the chromatin modification machinery reveals lineage specific gains, expansions, and losses.

DAnCER: disease-annotated chromatin epigenetics resource.

The program for processing newly synthesized histones H3.1 and H4.

Epistatic relationships reveal the functional organization of yeast transcription factors.

Structure of a SLC26 anion transporter STAS domain in complex with acyl carrier protein: implications for E. coli YchM in fatty acid metabolism.

Expanding the landscape of chromatin modification (CM)-related functional domains and genes in human.

Defining the budding yeast chromatin-associated interactome.

A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair.

OrthoNets: simultaneous visual analysis of orthologs and their interaction neighborhoods across different organisms.

Ribosome-dependent ATPase interacts with conserved membrane protein in Escherichia coli to modulate protein synthesis and oxidative phosphorylation.

Array-based synthetic genetic screens to map bacterial pathways and functional networks in Escherichia coli.

Identification of mammalian protein complexes by lentiviral-based affinity purification and mass spectrometry.

Genetic interaction maps in Escherichia coli reveal functional crosstalk among cell envelope biogenesis pathways.

Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B.

Hsp110 is required for spindle length control.

Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae.