Timothy S. Blackwell

Resident alveolar macrophages are replaced by recruited monocytes in response to endotoxin-induced lung inflammation.

Macrophages are necessary for maximal nuclear factor-kappa B activation in response to endotoxin.

Hepatic cryoablation-induced multisystem injury: bioluminescent detection of NF-kappaB activation in a transgenic mouse model.

Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice.

Modulation of endotoxin-induced NF-kappa B activation in lung and liver through TNF type 1 and IL-1 receptors.

Selective I kappa B kinase expression in airway epithelium generates neutrophilic lung inflammation.

Monocytes are potent facilitators of alveolar neutrophil emigration during lung inflammation: role of the CCL2-CCR2 axis.

Systemic nf-kappaB activation in a transgenic mouse model of acute pancreatitis.

Bioluminescent detection of endotoxin effects on HIV-1 LTR-driven transcription in vivo.

Endotoxin potentiates lung injury in cerulein-induced pancreatitis.

Mice are resistant to the induction of a pleurodesis.

Regulation of macrophage cyclooxygenase-2 gene expression by modifications of histone H3.

p47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia.

Transcriptional regulation of the cyclooxygenase-2 gene in macrophages by PU.1.

Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10.

Pneumolysin-induced lung injury is independent of leukocyte trafficking into the alveolar space.

CCR2-positive monocytes recruited to inflamed lungs downregulate local CCL2 chemokine levels.

Intratracheal administration of liposomal clodronate accelerates alveolar macrophage reconstitution following fetal liver transplantation.

Characterization of fibroblast-specific protein 1 in pulmonary fibrosis.

Pathogen-host interactions in Pseudomonas aeruginosa pneumonia.

Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta.

Variability of interalveolar septal remodeling after bleomycin treatment in mice.

Eotaxin-3 and interleukin-5 pleural fluid levels are associated with pleural fluid eosinophilia in post-coronary artery bypass grafting pleural effusions.

The effects of intrinsic pathway protease deficiencies on plasminogen-deficient mice.

Inducible binding of PU.1 and interacting proteins to the Toll-like receptor 4 promoter during endotoxemia.

Cyclopentenone isoprostanes inhibit the inflammatory response in macrophages.

Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease.

Nuclear factor-kappaB affects tumor progression in a mouse model of malignant pleural effusion.

Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin.

Bioluminescence imaging.

Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases.

Hyperoxia and apoptosis in developing mouse lung mesenchyme.

Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa.

Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury.

NIK is involved in nucleosomal regulation by enhancing histone H3 phosphorylation by IKKalpha.

Angiopoietin-1-induced angiogenesis is modulated by endothelial NADPH oxidase.

Vascular endothelial growth factor levels in post-CABG pleural effusions are associated with pleural inflammation and permeability.

Activation of nuclear factor kappa B and severe hepatic necrosis may mediate systemic inflammation in choline-deficient/ethionine-supplemented diet-induced pancreatitis.

Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells.

Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells.

Yin Yang 1 enhances cyclooxygenase-2 gene expression in macrophages.

A transgenic model reveals important roles for the NF-kappa B alternative pathway (p100/p52) in mammary development and links to tumorigenesis.

Bacterial clearance of Pseudomonas aeruginosa is enhanced by the inhibition of COX-2.

Airway epithelium controls lung inflammation and injury through the NF-kappa B pathway.

Interleukin-1beta is the primary initiator of pulmonary inflammation following liver injury in mice.

Association of progressive structural changes in the bronchial epithelium with subepithelial fibrous remodeling: a potential role for hypoxia.

Induction and function of lipocalin prostaglandin D synthase in host immunity.

Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice.

Tumor necrosis factor-alpha promotes malignant pleural effusion.

Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis.

Use of bioluminescent imaging to investigate the role of nuclear factor-kappaBeta in experimental non-small cell lung cancer metastasis.

Disease-specific gene expression profiling in multiple models of lung disease.

The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak.

Host nuclear factor-kappaB activation potentiates lung cancer metastasis.

Bioluminescence imaging visualizes activation of nuclear factor-kappaB in mouse cardiac transplantation.

Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection.

Genetic determination of the role of PU.1 in macrophage gene expression.

Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid.

The nuclear factor-kappaB pathway controls the progression of prostate cancer to androgen-independent growth.

A central role for tumor-derived monocyte chemoattractant protein-1 in malignant pleural effusion.

Bioluminescence: imaging modality for in vitro and in vivo gene expression.

Myeloid cells control termination of lung inflammation through the NF-kappaB pathway.

Lipopolysaccharide-dependent interaction between PU.1 and c-Jun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages.

Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart.

Development of animal models for the acute respiratory distress syndrome.

Reducing the activity and secretion of microbial antioxidants enhances the immunogenicity of BCG.

Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis.

CpG oligodeoxynucleotide triggers the liver inflammatory reaction and abrogates spontaneous tolerance.

The protein kinase IKKepsilon regulates energy balance in obese mice.

Activation of nuclear factor kappa B in mammary epithelium promotes milk loss during mammary development and infection.

Nuclear factor kappa B induction in airway epithelium increases lung inflammation in allergen-challenged mice.

TLR4 is necessary for hyaluronan-mediated airway hyperresponsiveness after ozone inhalation.

Discovery of an operon that participates in agmatine metabolism and regulates biofilm formation in Pseudomonas aeruginosa.

Specific effects of bortezomib against experimental malignant pleural effusion: a preclinical study.

Interleukin-32beta propagates vascular inflammation and exacerbates sepsis in a mouse model.

NADPH oxidase limits innate immune responses in the lungs in mice.

Identification of early interstitial lung disease in an individual with genetic variations in ABCA3 and SFTPC.

Role of NADPH oxidase in host defense against aspergillosis.

Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis.

Host-derived interleukin-5 promotes adenocarcinoma-induced malignant pleural effusion.

Pseudomonas aeruginosa: host defence in lung diseases.

Allergic inflammation does not impact chemical-induced carcinogenesis in the lungs of mice.

NF-kappaB activation limits airway branching through inhibition of Sp1-mediated fibroblast growth factor-10 expression.

Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages.

Let It Be: microRNAs impact interstitial lung disease.

TGFβ signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment.

Bronchial secretory immunoglobulin a deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease.

Hypoxia-inducible factor-1 signalling promotes goblet cell hyperplasia in airway epithelium.

Vitamin E prevents NRF2 suppression by allergens in asthmatic alveolar macrophages in vivo.

Idiopathic pulmonary fibrosis: a disorder of epithelial cell dysfunction.

Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs.

Alveolar epithelial cells undergo epithelial-to-mesenchymal transition in response to endoplasmic reticulum stress.

PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression.

NF-κB signaling in fetal lung macrophages disrupts airway morphogenesis.

Low-level laser therapy activates NF-kB via generation of reactive oxygen species in mouse embryonic fibroblasts.

NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis model.

NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs.

Meta-analysis and systematic review of procalcitonin-guided therapy in respiratory tract infections.

Leukocyte-derived extracellular superoxide dismutase does not contribute to airspace EC-SOD after interstitial pulmonary injury.

A critical role for macrophages in promotion of urethane-induced lung carcinogenesis.

Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense.

Right place, right time: the evolving role of herpesvirus infection as a "second hit" in idiopathic pulmonary fibrosis.

Structure and function of OprD protein in Pseudomonas aeruginosa: from antibiotic resistance to novel therapies.

Role of Endoplasmic Reticulum Stress in Age-Related Susceptibility to Lung Fibrosis.

Opposing effects of bortezomib-induced nuclear factor-κB inhibition on chemical lung carcinogenesis.

Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis.

Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier.

Telomerase deficiency does not alter bleomycin-induced fibrosis in mice.

Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice.

The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease.

Regulation of innate immunity by NADPH oxidase.

MicroRNA-181b regulates NF-κB-mediated vascular inflammation.

Cooperation Between Classical and Alternative NF-κB Pathways Regulates Pro-Inflammatory Responses in Epithelial Cells.

The Alveolar Epithelium Determines Susceptibility to Lung Fibrosis in Hermansky-Pudlak Syndrome.