JoVE Science Education

Biology I: yeast, Drosophila and C. elegans

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English

C. elegans Development and Reproduction

Overview

Ceanorhabditis elegans is a powerful tool to help understand how organisms develop from a single cell into a vast interconnected array of functioning tissues. Early work in C. elegans traced the complete cell lineage and structure at the electron microscopy level, allowing researchers unprecedented insight into the connection between genes, development and disease. Appreciating the stereotyped development and reproductive program of C. elegans is essential to using this model organism to its experimental fullest.

This video will give you a peek into the development of a worm from fertilization to hatching, and walk you though the life stages of the newly hatched larvae on its journey to reproductive maturity. The video will detail how the major axes are established, which founder cells give rise to what tissues in the developing embryo and how to discriminate between the four larval stages. Finally, you will learn how to set up a genetic cross and we"ll visit a few applications that manipulate the development and reproduction of C. elegans to experimental benefit.

Procedure

Caenorhabditis elegans is an anatomically small and genetically simple multicellular organism with an invariant pattern of development. Despite the fact that other organisms, like vertebrates, have more variable developmental programs, research on worm development and reproduction has yielded important insights into the molecular mechanisms that regulate development in a diverse array of species, including us. A good appreciation of worm development and its life cycle is critical for the success of genetic experi

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