April 6th, 2016
•We present a three-dimensional (3D) lung cancer model based on a biological collagen scaffold to study sensitivity towards non-small-cell-lung-cancer-(NSCLC)-targeted therapies. We demonstrate different read-out techniques to determine the proliferation index, apoptosis and epithelial-mesenchymal transition (EMT) status. Collected data are integrated into an in silico model for prediction of drug sensitivity.
Tags
Related Videos
Tissue Engineering of a Human 3D in vitro Tumor Test System
Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model
Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration
Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue
Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening
Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model
Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
Tissue-Engineered Graft for Circumferential Esophageal Reconstruction in Rats
Copyright © 2024 MyJoVE Corporation. 판권 소유