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Sophie Regan

MRC Centre for Drug Safety Science and Institute of Translational Medicine

University of Liverpool

BIOGRAPHY

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PUBLICATIONS

Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis.

Toxicology and applied pharmacology Sep, 2009 | Pubmed ID: 19523481

High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo.

Toxicological sciences : an official journal of the Society of Toxicology Dec, 2009 | Pubmed ID: 19783637

Acyl glucuronides: the good, the bad and the ugly.

Biopharmaceutics & drug disposition Oct, 2010 | Pubmed ID: 20830700

Convenient syntheses of benzo-fluorinated dibenz[b,f]azepines: rearrangements of isatins, acridines, and indoles.

Organic letters Oct, 2011 | Pubmed ID: 21939196

The genotoxic potential of methapyrilene using the alkaline Comet assay in vitro and in vivo.

Toxicology Dec, 2011 | Pubmed ID: 22015589

Haloarene derivatives of carbamazepine with reduced bioactivation liabilities: 2-monohalo and 2,8-dihalo derivatives.

Journal of medicinal chemistry Nov, 2012 | Pubmed ID: 23088585

The generation, detection, and effects of reactive drug metabolites.

Medicinal research reviews Sep, 2013 | Pubmed ID: 23090860

The impact of early postoperative pain on health-related quality of life.

Pain practice : the official journal of World Institute of Pain Sep, 2013 | Pubmed ID: 23279591

Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients.

The Journal of pharmacology and experimental therapeutics Aug, 2014 | Pubmed ID: 24902585

Timescale analysis of a mathematical model of acetaminophen metabolism and toxicity.

Journal of theoretical biology Dec, 2015 | Pubmed ID: 26348886

INSTITUTIONS

University of Liverpool

JOVE ARTICLES

Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture

Michael P. Storm¹,

Ian Sorrell²,

Rebecca Shipley³,

Sophie Regan²,

Kim A. Luetchford¹,

Jean Sathish²,

Steven Webb⁴,

Marianne J. Ellis¹

¹Department of Chemical Engineering and Centre for Regenerative Medicine, University of Bath,

²MRC Centre for Drug Safety Science and Institute of Translational Medicine, University of Liverpool,

³Mechanical Engineering, University College London,

⁴Department of Applied Mathematics, Liverpool John Moores University

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Sophie Regan

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}MRC Centre for Drug Safety Science and Institute of Translational Medicine

University of Liverpool

Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture

MRC Centre for Drug Safety Science and Institute of Translational Medicine