Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.

Clinical Manifestations:

1. Cervical Esophageal Perforations: Symptoms may include neck pain, difficulty swallowing, painful swallowing, changes in voice quality, and possibly a crackling sensation or tenderness upon neck palpation.
2. Thoracic Esophageal Perforations: Often present with sharp chest pain behind the breastbone, with nausea and vomiting commonly seen in Boerhaave syndrome cases.
3. Abdominal Esophageal Perforation: It is characterized by epigastric pain that may radiate to the shoulder, accompanied by nausea or vomiting.

Transmural tears can lead to peritoneal contamination and acute peritonitis.

Diagnostic Evaluation:

Diagnosis involves plain radiography, contrast esophagography, and computed tomography scans of the chest and abdomen. These imaging techniques detect air escape from the perforated esophagus, confirm the diagnosis, and identify intrathoracic or intra-abdominal collections needing drainage.

Management Approaches:

Initial management includes ICU admission for monitoring, volume resuscitation, and stabilization. Treatment typically involves broad-spectrum antibiotics, antifungals, and intravenous proton pump inhibitors. Percutaneous drainage is performed if fluid collection is present. Management decisions between operative and nonoperative approaches are critical.

1. Endoscopic Stent Placement: Considered for stable patients.
2. Surgical Drainage: Often necessary for most esophageal perforations, including debridement of devitalized contaminated tissue and primary repair.
3. Diversion Procedures or Resection: In rare cases, esophagectomy and feeding gastrostomy/jejunostomy are involved.
4. Postoperative Care: May include a feeding jejunostomy or gastrostomy tube to facilitate healing by allowing the esophagus to rest from oral feeding.