Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

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12.1K Views

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09:38 min

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September 12th, 2016

DOI :

10.3791/54348-v

September 12th, 2016

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Kirsten S. Evonuk*¹, Carson E. Moseley*², Ryan E. Doyle¹, Casey T. Weaver², Tara M. DeSilva¹^,³^,⁴

¹Physical Medicine and Rehabilitation, University of Alabama at Birmingham, ²Department of Pathology, University of Alabama at Birmingham, ³Department of Neurobiology, University of Alabama at Birmingham, ⁴Center for Glial Biology and Medicine, University of Alabama at Birmingham

Podsumowanie

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Keywords Immune System Suppression

CNS Protection

Pharmacological Interventions

Autoimmune Demyelination

Experimental Autoimmune Encephalomyelitis EAE

Multiple Sclerosis

System Xc transporter Inhibitor

Rozdziały w tym wideo

0:05

Title

4:44

Quantification of Reactive Gliosis Using Mean Fraction Area and Myelin Using Optical Density

2:57

Central Nervous System (CNS) CD4⁺ T Cell Phenotype Assessment

6:52

Results: System Xc-transporter Inhibition Attenuates T Cell CNS Infiltration and Myelin Destruction

8:31

Conclusion

1:10

Brain and Spinal Cord Immune Cell Isolation

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