Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

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10:22 min

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December 6th, 2016

DOI :

10.3791/54883-v

December 6th, 2016

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Christos Papadelis¹, Eleonora Tamilia¹, Steven Stufflebeam², Patricia E. Grant¹, Joseph R. Madsen³, Phillip L. Pearl⁴, Naoaki Tanaka²

¹Fetal-Neonatal Neuroimaging and Developmental Science Center, Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical School, ²Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, ³Division of Epilepsy Surgery, Department of Neurosurgery, Boston Children's Hospital, Harvard Medical School, ⁴Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School

Podsumowanie

High Frequency Oscillations (HFOs) have emerged as presurgical biomarkers for the identification of the epileptogenic zone in pediatric patients with medically refractory epilepsy. A methodology for the noninvasive recording, detection, and localization of HFOs with simultaneous scalp electroencephalography (EEG) and magnetoencephalography (MEG) is presented.

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High frequency Oscillations

Interictal

Magnetoencephalography

Electroencephalography

Pediatric Epilepsy

Inverse Problem

Biomarker

Non invasive Localization

Epileptogenic Zone

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