Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents

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7.5K Views

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06:51 min

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August 10th, 2018

DOI :

10.3791/55724-v

August 10th, 2018

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Naemeh Pourshafie¹, Philip R. Lee², Ke-lian Chen¹, George G. Harmison¹, Laura C. Bott¹^,³, Kenneth H. Fischbeck¹, Carlo Rinaldi¹^,⁴

¹Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, ²Section on Nervous System Development and Plasticity, The Eunice Kennedy Shriver National Institute of Child and Human Development, National Institutes of Health, ³Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, ⁴Department of Physiology, Anatomy and Genetics, University of Oxford

Podsumowanie

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Keywords MicroRNA

Adeno associated Virus Serotype 9

Neuromuscular Diseases

Rozdziały w tym wideo

0:04

Title

0:48

Tail Vein Injection of AAV-miRNA Plasmid

2:14

Behavioral Assays: Hanging Wire and Foot Print Assay

3:30

Tissue Harvest

4:27

Results: Treatment of SBMA Mice with miRNA

5:59

Conclusion

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