High-sensitivity Detection of Micrometastases Generated by GFP Lentivirus-transduced Organoids Cultured from a Patient-derived Colon Tumor

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9.9K Views

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09:16 min

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June 14th, 2018

DOI :

10.3791/57374-v

June 14th, 2018

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Yu Okazawa¹^,², Kosuke Mizukoshi¹^,², Yu Koyama²^,⁴, Shoki Okubo⁵, Hiromitsu Komiyama¹, Yutaka Kojima¹, Michitoshi Goto¹, Sonoko Habu³, Okio Hino², Kazuhiro Sakamoto¹, Akira Orimo²

¹Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, ²Department of Molecular Pathogenesis, Juntendo University Faculty of Medicine, ³Atopy Research Center, Juntendo University Faculty of Medicine, ⁴Department of Oral Pathobiological Science and Surgery, Tokyo Dental College, ⁵Department of Gastroenterology, Juntendo University Faculty of Medicine

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Keywords Micrometastases

GFP Lentivirus

Patient derived Colon Tumor

Rozdziały w tym wideo

0:04

Title

0:57

Colorectal Cancer Cell (CRC) Organoid Artificial Extracellular Matrix Culture Installation

2:42

CRC Organic Cell-labeling with GFP Lentiviral Particles

5:28

GFP-labeled CRC Organoid Metastasis Generation

7:55

Results: Representative High-resolution GFP Visualization in Cultured GFP-labeled CRC Organoids, Primary Tumors, and Micrometastases

8:38

Conclusion

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