SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

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23.6K Views

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07:39 min

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June 28th, 2019

DOI :

10.3791/58133-v

June 28th, 2019

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Heike Fuhrmann-Stroissnigg*¹, Fernando E. Santiago*¹^,²^,³, Diego Grassi¹, YuanYuan Ling¹, Laura J. Niedernhofer¹^,²^,³, Paul D. Robbins¹^,²^,³

¹Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, ²Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, ³Institute on the Biology of Aging and Metabolism, University of Minnesota

Podsumowanie

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Keywords SA Galactosidase

Senotherapeutic Drugs

Senolytic

Senomorphic

High throughput Drug Screening

Aging related Diseases

Cell Senescence

Cell Culture

Trypsinization

Rozdziały w tym wideo

0:04

Title

1:06

Generation of Senescent Murine Embryonic Fibroblast (MEF) 12-15 Days

3:46

Senescent Associated -Galactosidase (SA--Gal) Screening Assay 2-3 Days

6:06

Results: Identification of Senotherapeutics by Measuring SA--Gal Activity in Single Cells

6:48

Conclusion

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