Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
Please note that all translations are automatically generated. Click here for the English version.
5.0K Views
•
08:35 min
•
May 29th, 2021
DOI :
May 29th, 2021
•Alice Douangamath*1,2, Ailsa Powell*1,2, Daren Fearon*1,2, Patrick M. Collins1,2, Romain Talon1,2,3, Tobias Krojer3,4, Rachael Skyner1,2, Jose Brandao-Neto1,2, Louise Dunnett1,2, Alexandre Dias1,2, Anthony Aimon1,2,3, Nicholas M. Pearce1,3, Conor Wild3,5, Tyler Gorrie-Stone1, Frank von Delft1,2,3,4,6
1Diamond Light Source Ltd, Harwell Science and Innovation Campus, 2Research Complex at Harwell, Harwell Science and Innovation Campus, 3Structural Genomics Consortium, University of Oxford, 4Centre for Medicines Discovery, University of Oxford, 5Oxford Protein Informatics Group, Department of Statistics, Oxford University, 6Department of Biochemistry, University of Johannesburg
Rozdziały w tym wideo
0:04
Introduction
0:49
Fragment Screening Experiment
1:31
Crystal Soaking
2:27
Crystal Harvesting
3:31
Data Collection
4:02
Data Analysis
6:47
Results: XChem Screen of the Main Protease of SARS‐CoV‐2
7:59
Conclusion
Powiązane Filmy
08:53
Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092
29.8K Views
10:12
Synchrotron X-ray Microdiffraction and Fluorescence Imaging of Mineral and Rock Samples
8.9K Views
06:19
Fixed Target Serial Data Collection at Diamond Light Source
3.2K Views
06:29
Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin
5.4K Views
09:19
NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode
3.2K Views
09:00
A Sample Preparation Pipeline for Microcrystals at the VMXm Beamline
2.8K Views
10:32
Sample Preparation and Transfer Protocol for In-Vacuum Long-Wavelength Crystallography on Beamline I23 at Diamond Light Source
2.6K Views
06:26
Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery
4.7K Views
07:24
Quantitative Atomic-Site Analysis of Functional Dopants/Point Defects in Crystalline Materials by Electron-Channeling-Enhanced Microanalysis
5.5K Views
07:08
Crystallization and In Situ Room Temperature Data Collection Using the Crystallization Facility at Harwell and Beamline VMXi, Diamond Light Source
3.3K Views
Copyright © 2025 MyJoVE Corporation. Wszelkie prawa zastrzeżone