Methods Article

Development and Optimization of A Human Hepatocellular Carcinoma Patient-Derived Organoid Model for Potential Target Identification and Drug Discovery

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1.3K Views

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07:25 min

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August 18th, 2023

DOI :

10.3791/65785-v

August 18th, 2023

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Cheng-Yang Zhang*¹^,², Xiao-Feng Zhang*³, Jun Yuan*¹^,², Yuan-Feng Gong⁴, Hui Tang⁴, Wan-Yu Guo¹^,², Tong-Yan Li¹^,², Cai-Wen Li¹^,², Yun-Qiang Tang⁴, Ning-Fang Ma¹^,², Ming Liu¹^,²

¹Affiliated Cancer Hospital and Institute of Guangzhou Medical University, ²Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Center for Cancer Research and Translational Medicine, School of Basic Medical Sciences, Guangzhou Medical University, ³Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, ⁴Department of Hepatobiliary Surgery, Affiliated Cancer Hospital, Guangzhou Medical University

Transkrypcja

Podsumowanie

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Hepatocellular Carcinoma

Organoid Model

Drug Discovery

Molecular Pathogenesis

Therapeutic Targets

Cancer Metastasis

Organoid Culture

Patient derived Organoids

Rozdziały w tym wideo

0:00

Introduction

1:26

Hepatocellular Carcinoma Tissue Dissociation for Organoid Culture

3:27

Hepatocellular Carcinoma Organoid Culture and Digestion to Study Liver Cancer Pathogenesis

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