Kostas Kostarelos

Rational design and engineering of delivery systems for therapeutics: biomedical exercises in colloid and surface science.

Binding and interstitial penetration of liposomes within avascular tumor spheroids.

Functionalized carbon nanotubes for plasmid DNA gene delivery.

Liposome-mediated radiotherapeutics within avascular tumor spheroids: comparative dosimetry study for various radionuclides, liposome systems, and a targeting antibody.

Light-sensitive fusion between polymer-coated liposomes following physical anchoring of polymerisable polymers onto lipid bilayers by self-assembly.

Biomedical applications of functionalised carbon nanotubes.

Binding and condensation of plasmid DNA onto functionalized carbon nanotubes: toward the construction of nanotube-based gene delivery vectors.

Internal microdosimetry for single cells in radioimmunotherapy of B-cell lymphoma.

Synthesis and application of integrin targeting lipopeptides in targeted gene delivery.

Engineering lipid vesicles of enhanced intratumoral transport capabilities: correlating liposome characteristics with penetration into human prostate tumor spheroids.

Applications of carbon nanotubes in drug delivery.

Synthetic, self-assembly ABCD nanoparticles; a structural paradigm for viable synthetic non-viral vectors.

What role can chemistry play in cationic liposome-based gene therapy research today?

What Role Can Chemistry Play in Cationic Liposome-Based Gene Therapy Research Today?

Carbon nanotubes: on the road to deliver.

Functionalized carbon nanotubes as emerging nanovectors for the delivery of therapeutics.

Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers.

Double functionalization of carbon nanotubes for multimodal drug delivery.

Carbon nanotubes as nanomedicines: from toxicology to pharmacology.

Construction of nanoscale multicompartment liposomes for combinatory drug delivery.

Single-cell dosimetry for radioimmunotherapy of B-cell lymphoma patients with special reference to leukemic spread.

Establishing nanomedicine.

Liposome-nanoparticle hybrids for multimodal diagnostic and therapeutic applications.

The emergence of nanomedicine: a field in the making.

Multifunctionalised cationic fullerene adducts for gene transfer: design, synthesis and DNA complexation.

Functionalized carbon nanotubes in drug design and discovery.

Multiwalled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics.

Opportunities and challenges of carbon-based nanomaterials for cancer therapy.

Tissue histology and physiology following intravenous administration of different types of functionalized multiwalled carbon nanotubes.

Hype around nanotubes creates unrealistic hopes.

Artificial envelopment of nonenveloped viruses: enhancing adenovirus tumor targeting in vivo.

The long and short of carbon nanotube toxicity.

Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type.

Carbon-nanotube shape and individualization critical for renal excretion.

Functionalized-quantum-dot-liposome hybrids as multimodal nanoparticles for cancer.

Synthesis and analysis of novel glycerolipids for the treatment of metabolic syndrome.

Nanoengineering artificial lipid envelopes around adenovirus by self-assembly.

Lipid-quantum dot bilayer vesicles enhance tumor cell uptake and retention in vitro and in vivo.

Designer adenoviruses for nanomedicine and nanodiagnostics.

Antitumor activity and prolonged survival by carbon-nanotube-mediated therapeutic siRNA silencing in a human lung xenograft model.

Synthesis and characterization of a carbon nanotube-dendron series for efficient siRNA delivery.

Blood circulation and tissue biodistribution of lipid--quantum dot (L-QD) hybrid vesicles intravenously administered in mice.

Tumor targeting of functionalized quantum dot-liposome hybrids by intravenous administration.

Nanoparticles functionalized with recombinant single chain Fv antibody fragments (scFv) for the magnetic resonance imaging of cancer cells.

Chapter 17 - Engineering cationic liposome siRNA complexes for in vitro and in vivo delivery.

Systemic antiangiogenic activity of cationic poly-L-lysine dendrimer delays tumor growth.

Enhanced anticancer activity of multi-walled carbon nanotube-methotrexate conjugates using cleavable linkers.

Functionalized carbon nanotubes for probing and modulating molecular functions.

Nanorobots for medicine: how close are we?

Assessment of cellular uptake and cytotoxicity of carbon nanotubes using flow cytometry.

Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging.

Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes.

Carbon nanotubes: Fibrillar pharmacology.

Hybrid polymer-grafted multiwalled carbon nanotubes for in vitro gene delivery.

Physiologically based pharmacokinetic modeling of nanoparticles.

Intracellular trafficking and gene expression of pH-sensitive, artificially enveloped adenoviruses in vitro and in vivo.

Doxorubicin-loaded lipid-quantum dot hybrids: surface topography and release properties.

Cytotoxic assessment of carbon nanotube interaction with cell cultures.

Cellular uptake mechanisms of functionalised multi-walled carbon nanotubes by 3D electron tomography imaging.

Antibody covalent immobilization on carbon nanotubes and assessment of antigen binding.

Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura.

Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing.

Making carbon nanotubes biocompatible and biodegradable.

Liposomes: from a clinically established drug delivery system to a nanoparticle platform for theranostic nanomedicine.

Cellular uptake and cytotoxic impact of chemically functionalized and polymer-coated carbon nanotubes.

Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis.

Carbon nanotube-mediated wireless cell permeabilization: drug and gene uptake.

Translocation mechanisms of chemically functionalised carbon nanotubes across plasma membranes.

Targeting carbon nanotubes against cancer.

Pharmacokinetics & tissue distribution of temperature-sensitive liposomal doxorubicin in tumor-bearing mice triggered with mild hyperthermia.

Therapeutics, imaging and toxicity of nanomaterials in the central nervous system.

Application of carbon nanotubes in neurology: clinical perspectives and toxicological risks.

Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile.

In vivo degradation of functionalized carbon nanotubes after stereotactic administration in the brain cortex.

The alluring potential of functionalized carbon nanotubes in drug discovery.

Liposome-gold nanorod hybrids for high-resolution visualization deep in tissues.

Lipid-peptide vesicle nanoscale hybrids for triggered drug release by mild hyperthermia in vitro and in vivo.

A high poly(ethylene glycol) density on graphene nanomaterials reduces the detachment of lipid-poly(ethylene glycol) and macrophage uptake.

The effect of artificial lipid envelopment of Adenovirus 5 (Ad5) on liver de-targeting and hepatotoxicity.

Safety considerations for graphene: lessons learnt from carbon nanotubes.

Purified graphene oxide dispersions lack in vitro cytotoxicity and in vivo pathogenicity.

Electroresponsive polymer-carbon nanotube hydrogel hybrids for pulsatile drug delivery in vivo.

Asbestos-like pathogenicity of long carbon nanotubes alleviated by chemical functionalization.

In vivo cell reprogramming towards pluripotency by virus-free overexpression of defined factors.

The effective nuclear delivery of doxorubicin from dextran-coated gold nanoparticles larger than nuclear pores.

Autophagy and formation of tubulovesicular autophagosomes provide a barrier against nonviral gene delivery.

Prospects and challenges of graphene in biomedical applications.

Cationic poly-L-lysine dendrimer complexes doxorubicin and delays tumor growth in vitro and in vivo.

Pulmonary DWCNT exposure causes sustained local and low-level systemic inflammatory changes in mice.

Ammonium and Guanidinium Dendron-Carbon Nanotubes by Amidation and Click Chemistry and their Use for siRNA Delivery.

How do functionalized carbon nanotubes land on, bind to and pierce through model and plasma membranes.

Pharmacology of carbon nanotubes: Toxicokinetics, excretion and tissue accumulation.

Carbon nanotubes as vectors for gene therapy: Past achievements, present challenges and future goals.

Carbon nanotubes in medicine and biology - Safety and toxicology.

Hemotoxicity of carbon nanotubes.

Carbon nanotubes in medicine & biology - Therapy and diagnostics.

Functionalized carbon nanotubes in the brain: cellular internalization and neuroinflammatory responses.