Department of Medicinal Chemistry and Molecular Pharmacology
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Molecular mechanisms for heterologous sensitization of adenylate cyclase.
The Journal of pharmacology and experimental therapeutics Jul, 2002 | Pubmed ID: 12065693
Heterologous sensitization of adenylate cyclase is protein kinase A-dependent in Cath.a differentiated (CAD)-D2L cells.
Journal of neurochemistry Sep, 2002 | Pubmed ID: 12358756
Serotonin 5-hydroxytryptamine 2A receptor-coupled phospholipase C and phospholipase A2 signaling pathways have different receptor reserves.
The Journal of pharmacology and experimental therapeutics Jan, 2003 | Pubmed ID: 12490596
A complex signaling cascade links the serotonin2A receptor to phospholipase A2 activation: the involvement of MAP kinases.
Journal of neurochemistry Aug, 2003 | Pubmed ID: 12887695
Sensitization of adenylate cyclase: a general mechanism of neuroadaptation to persistent activation of Galpha(i/o)-coupled receptors?
Life sciences Oct, 2003 | Pubmed ID: 14519441
Sensitization of neuronal A2A adenosine receptors after persistent D2 dopamine receptor activation.
The Journal of pharmacology and experimental therapeutics Jan, 2004 | Pubmed ID: 14566008
Sensitization of adenylate cyclase by short-term activation of 5-HT1A receptors.
Cellular signalling Dec, 2003 | Pubmed ID: 14575866
Novel regulatory properties of human type 9 adenylate cyclase.
The Journal of pharmacology and experimental therapeutics Jul, 2004 | Pubmed ID: 14996950
Differentiation-induced alterations in cyclic AMP signaling in the Cath.a differentiated (CAD) neuronal cell line.
Journal of neurochemistry Mar, 2004 | Pubmed ID: 15009651
Sexual experience alters D1 receptor-mediated cyclic AMP production in the nucleus accumbens of female Syrian hamsters.
Synapse (New York, N.Y.) Jul, 2004 | Pubmed ID: 15150737
Using molecular tools to dissect the role of Galphas in sensitization of AC1.
Molecular pharmacology Dec, 2004 | Pubmed ID: 15361543
Protein kinase C and epidermal growth factor stimulation of Raf1 potentiates adenylyl cyclase type 6 activation in intact cells.
Molecular pharmacology Jan, 2005 | Pubmed ID: 15470083
Activation of a novel PKC isoform synergistically enhances D2L dopamine receptor-mediated sensitization of adenylate cyclase type 6.
Cellular signalling May, 2005 | Pubmed ID: 15683739
Galphaq potentiation of adenylate cyclase type 9 activity through a Ca2+/calmodulin-dependent pathway.
Biochemical pharmacology Apr, 2005 | Pubmed ID: 15794946
Galphaq-coupled receptor signaling enhances adenylate cyclase type 6 activation.
Biochemical pharmacology Jul, 2005 | Pubmed ID: 15885660
Dexras1 blocks receptor-mediated heterologous sensitization of adenylyl cyclase 1.
Biochemical and biophysical research communications Jul, 2005 | Pubmed ID: 15913563
Sensitization of adenylate cyclase by Galpha i/o-coupled receptors.
Pharmacology & therapeutics Jun, 2005 | Pubmed ID: 15922020
Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange.
Structure (London, England : 1993) Jul, 2005 | Pubmed ID: 16004878
A bifunctional Galphai/Galphas modulatory peptide that attenuates adenylyl cyclase activity.
FEBS letters Oct, 2005 | Pubmed ID: 16225870
D2 dopamine receptor-induced sensitization of adenylyl cyclase type 1 is G alpha(s) independent.
Neuropharmacology Apr, 2006 | Pubmed ID: 16376953
Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C delta: implications for adenylyl cyclase 2 signaling.
Molecular pharmacology May, 2006 | Pubmed ID: 16489124
Regulatory properties of adenylate cyclases type 5 and 6: A progress report.
European journal of pharmacology Mar, 2006 | Pubmed ID: 16527269
Repeated quinpirole treatments produce neurochemical sensitization and associated behavioral changes in female hamsters.
Psychopharmacology Sep, 2006 | Pubmed ID: 16850118
WAY-100635 is a potent dopamine D4 receptor agonist.
Psychopharmacology Oct, 2006 | Pubmed ID: 16915381
trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist.
Journal of medicinal chemistry Nov, 2006 | Pubmed ID: 17154515
Adenylyl cyclase isoforms as novel therapeutic targets: an exciting example of excitotoxicity neuroprotection.
Molecular interventions Apr, 2007 | Pubmed ID: 17468386
Adenylyl cyclase 5: a new clue in the search for the "fountain of youth"?
Science's STKE : signal transduction knowledge environment Nov, 2007 | Pubmed ID: 18029912
Ligand-dependent oligomerization of dopamine D(2) and adenosine A(2A) receptors in living neuronal cells.
Molecular pharmacology Sep, 2008 | Pubmed ID: 18524886
A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics.
The Journal of biological chemistry Dec, 2008 | Pubmed ID: 18984596
Adenosine A(2A) receptors assemble into higher-order oligomers at the plasma membrane.
FEBS letters Dec, 2008 | Pubmed ID: 19013155
Comparison of the enantiomers of (+/-)-doxanthrine, a high efficacy full dopamine D(1) receptor agonist, and a reversal of enantioselectivity at D(1) versus alpha(2C) adrenergic receptors.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology Feb, 2009 | Pubmed ID: 19028082
Fluorescent and bioluminescent protein-fragment complementation assays in the study of G protein-coupled receptor oligomerization and signaling.
Molecular pharmacology Apr, 2009 | Pubmed ID: 19141658
The intracellular II-III loops of Cav1.2 and Cav1.3 uncouple L-type voltage-gated Ca2+ channels from glucagon-like peptide-1 potentiation of insulin secretion in INS-1 cells via displacement from lipid rafts.
The Journal of pharmacology and experimental therapeutics Jul, 2009 | Pubmed ID: 19351867
Ligand-induced regulation and localization of cannabinoid CB1 and dopamine D2L receptor heterodimers.
The Journal of pharmacology and experimental therapeutics Mar, 2010 | Pubmed ID: 20016021
Visualization of G protein-coupled receptor (GPCR) interactions in living cells using bimolecular fluorescence complementation (BiFC).
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] Apr, 2010 | Pubmed ID: 20373507
Fluorescent protein complementation assays: new tools to study G protein-coupled receptor oligomerization and GPCR-mediated signaling.
Molecular and cellular endocrinology Jan, 2011 | Pubmed ID: 20654687
Facile synthesis of octahydrobenzo[h]isoquinolines: novel and highly potent D1 dopamine agonists.
Bioorganic & medicinal chemistry Sep, 2010 | Pubmed ID: 20709559
Molecular and pharmacological characterization of two D(1)-like dopamine receptors in the Lyme disease vector, Ixodes scapularis.
Insect biochemistry and molecular biology Aug, 2011 | Pubmed ID: 21457782
Mapping the catechol binding site in dopamine D₁ receptors: synthesis and evaluation of two parallel series of bicyclic dopamine analogues.
ChemMedChem Jun, 2011 | Pubmed ID: 21538900
Probing the steric space at the floor of the D1 dopamine receptor orthosteric binding domain: 7α-, 7β-, 8α-, and 8β-methyl substituted dihydrexidine analogues.
Journal of medicinal chemistry Aug, 2011 | Pubmed ID: 21714510
Assessment of dopamine D₁ receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393.
Bioorganic & medicinal chemistry Sep, 2011 | Pubmed ID: 21862338
Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines.
European journal of medicinal chemistry Feb, 2012 | Pubmed ID: 22204903
Comparison of the D₁ dopamine full agonists, dihydrexidine and doxanthrine, in the 6-OHDA rat model of Parkinson's disease.
Psychopharmacology Jul, 2012 | Pubmed ID: 22222862
A "genome-to-lead" approach for insecticide discovery: pharmacological characterization and screening of Aedes aegypti D(1)-like dopamine receptors.
PLoS neglected tropical diseases Jan, 2012 | Pubmed ID: 22292096
Ligand-specific roles for transmembrane 5 serine residues in the binding and efficacy of dopamine D(1) receptor catechol agonists.
Molecular pharmacology May, 2012 | Pubmed ID: 22334593
Dopamine D(2) Receptor-Mediated Heterologous Sensitization of AC5 Requires Signalosome Assembly.
Journal of signal transduction , 2012 | Pubmed ID: 22523680
Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D₃ receptor-selective full agonist ligand.
Bioorganic & medicinal chemistry Nov, 2012 | Pubmed ID: 23018094
Discovery of antagonists of tick dopamine receptors via chemical library screening and comparative pharmacological analyses.
Insect biochemistry and molecular biology Nov, 2012 | Pubmed ID: 23213654
Bimolecular fluorescence complementation analysis of G protein-coupled receptor dimerization in living cells.
Methods in enzymology , 2013 | Pubmed ID: 23351744
Differential effects of AGS3 expression on D(2L) dopamine receptor-mediated adenylyl cyclase signaling.
Cellular and molecular neurobiology May, 2013 | Pubmed ID: 23504261
Cell-type specific increases in female hamster nucleus accumbens spine density following female sexual experience.
Brain structure & function Aug, 2013 | Pubmed ID: 23934655
Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor.
The Journal of pharmacology and experimental therapeutics Nov, 2013 | Pubmed ID: 24008337
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