Philip C. Calder

Lipids and the critically ill patient.

New evidence in support of the cardiovascular benefit of long-chain n-3 fatty acids.

The effect of feeding structured triacylglycerols enriched in eicosapentaenoic or docosahexaenoic acids on murine splenocyte fatty acid composition and leucocyte phagocytosis.

Incorporation of cis-9,trans-11 or trans-10,cis-12 conjugated linoleic acid into plasma and cellular lipids in healthy men.

Dietary lipids and vascular function: UK Food Standards Agency workshop report.

n-3 polyunsaturated fatty acids and colon cancer prevention.

Differences in matrix metalloproteinase-1 and matrix metalloproteinase-12 transcript levels among carotid atherosclerotic plaques with different histopathological characteristics.

Using different intravenous lipids: underutilized therapeutic approaches?

N-3 polyunsaturated fatty acids and allergic disease.

The influence of different combinations of gamma-linolenic, stearidonic and eicosapentaenoic acids on the fatty acid composition of blood lipids and mononuclear cells in human volunteers.

n-3 Fatty acids and cardiovascular disease: evidence explained and mechanisms explored.

The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects.

PASSCLAIM--gut health and immunity.

Peripheral blood mononuclear cell fatty acid composition and inflammatory mediator production in adult Crohn's disease.

Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans.

Umbilical cord and maternal blood red cell fatty acids and early childhood wheezing and eczema.

Role of single nucleotide polymorphisms of pro-inflammatory cytokine genes in the relationship between serum lipids and inflammatory parameters, and the lipid-lowering effect of fish oil in healthy males.

The effect of dietary supplementation with linoleic acid to late gestation ewes on the fatty acid composition of maternal and fetal plasma and tissues and the synthetic capacity of the placenta for 2-series prostaglandins.

Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn disease.

Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on immune cell function in healthy humans.

Plasma cytokine response during the postprandial period: a potential causal process in vascular disease?

Is there a case for n-3 fatty acid supplementation in cystic fibrosis?

n-3 fatty acids, inflammation, and immunity--relevance to postsurgical and critically ill patients.

Differential anti-inflammatory effects of phenolic compounds from extra virgin olive oil identified in human whole blood cultures.

Effects of polyphenols on human Th1 and Th2 cytokine production.

Lifelong exposure to dietary fish oil alters macrophage responses in Walker 256 tumor-bearing rats.

The effects of conjugated linoleic acid on human health-related outcomes.

Incorporation of cis-9, trans-11 conjugated linoleic acid and vaccenic acid (trans-11 18 : 1) into plasma and leucocyte lipids in healthy men consuming dairy products naturally enriched in these fatty acids.

High-dose fish oil and antioxidants in Crohn's disease and the response of bone turnover: a randomised controlled trial.

Markers to measure immunomodulation in human nutrition intervention studies.

Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults.

Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men.

Fish oil alters T-lymphocyte proliferation and macrophage responses in Walker 256 tumor-bearing rats.

CD36: taste the difference?

Ratio of n6 to n-3 fatty acids in the diet affects tumor growth and cachexia in Walker 256 tumor-bearing rats.

Limited effect of eicosapentaenoic acid on T-lymphocyte and natural killer cell numbers and functions in healthy young males.

Effects of dairy products naturally enriched with cis-9,trans-11 conjugated linoleic acid on the blood lipid profile in healthy middle-aged men.

Self-reported health problems in young male subjects supplementing their diet with oils rich in eicosapentaenoic, gamma-linolenic and stearidonic acids.

Polyunsaturated fatty acids and inflammation.

n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases.

Polyunsaturated fatty acid concentrations in young men and women consuming their habitual diets.

Age- and dose-dependent effects of an eicosapentaenoic acid-rich oil on cardiovascular risk factors in healthy male subjects.

Use of fish oil in parenteral nutrition: Rationale and reality.

Lack of effect of meal fatty acid composition on postprandial lipid, glucose and insulin responses in men and women aged 50-65 years consuming their habitual diets.

Differences in maternal protein intake in pregnant rats alone alter the docosahexaenoic acid concentration in the fetal and adult offspring.

Early nutrition and immunity - progress and perspectives.

Age-related increases in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrations.

Decreased tumor growth in Walker 256 tumor-bearing rats chronically supplemented with fish oil involves COX-2 and PGE2 reduction associated with apoptosis and increased peroxidation.

Olive oil in parenteral nutrition.

Lipid rafts--composition, characterization, and controversies.

Immunological parameters: what do they mean?

Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease.

Immune modulation by parenteral lipid emulsions.

Membrane fatty acids, oxidative burst and phagocytosis after enrichment of P388D1 monocyte/macrophages with essential 18-carbon fatty acids.

Glucose metabolism in lymphoid and inflammatory cells and tissues.

Fish oil induced increase in walking distance, but not ankle brachial pressure index, in peripheral arterial disease is dependent on both body mass index and inflammatory genotype.

Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells.

Dietary arachidonic acid: harmful, harmless or helpful?

Immunonutrition in surgical and critically ill patients.

Fatty acids and immune function: new insights into mechanisms.

Dietary supplementation with fish oil modifies the ability of human monocytes to induce an inflammatory response.

Immunomodulation by omega-3 fatty acids.

UK Food Standards Agency Workshop Report: the effects of the dietary n-6:n-3 fatty acid ratio on cardiovascular health.

Gender differences in the n-3 fatty acid content of tissues.

Omega-3 fatty acids: time to get the messages right!

Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases.

Polymorphisms in the CD36 gene modulate the ability of fish oil supplements to lower fasting plasma triacyl glycerol and raise HDL cholesterol concentrations in healthy middle-aged men.

Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN Study.

Record citations in 2007, but impact factor slips.

Prebiotics, immune function, infection and inflammation: a review of the evidence.

Session 3: Joint Nutrition Society and Irish Nutrition and Dietetic Institute Symposium on 'Nutrition and autoimmune disease' PUFA, inflammatory processes and rheumatoid arthritis.

Fish oil n-3 polyunsaturated fatty acids selectively affect plasma cytokines and decrease illness in Thai schoolchildren: a randomized, double-blind, placebo-controlled intervention trial.

The relationship between the fatty acid composition of immune cells and their function.

Whole-blood culture is a valid low-cost method to measure monocytic cytokines - a comparison of cytokine production in cultures of human whole-blood, mononuclear cells and monocytes.

Dietary alpha-linolenic acid and health-related outcomes: a metabolic perspective.

Acute consumption of fish oil improves postprandial VLDL profiles in healthy men aged 50-65 years.

Early life programming of immune and lung function: can we now exclude a role of arachidonic acid exposure?

Who should be an author?

Managing hypercholesterolemia and its correlation with carotid plaque morphology in patients undergoing carotid endarterectomy.

Omega-3 polyunsaturated fatty acids and human health outcomes.

Hot topics in parenteral nutrition. Rationale for using new lipid emulsions in parenteral nutrition and a review of the trials performed in adults.

Polyunsaturated fatty acids and inflammatory processes: New twists in an old tale.

Reduced ex vivo interleukin-6 production by dietary fish oil is not modified by linoleic acid intake in healthy men.

Hsp70 expression in monocytes from patients with peripheral arterial disease and healthy controls: monocyte Hsp70 in PAD.

BJN impact factor rises.

Omega-3 Fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment.

Effects of fat and fatty acid intake on inflammatory and immune responses: a critical review.

The 2008 ESPEN Sir David Cuthbertson Lecture: Fatty acids and inflammation--from the membrane to the nucleus and from the laboratory bench to the clinic.

Understanding omega-3 polyunsaturated fatty acids.

The effect of three lipid emulsions differing in fatty acid composition on growth, apoptosis and cell cycle arrest in the HT-29 colorectal cancer cell line.

Fatty acids and immune function: relevance to inflammatory bowel diseases.

Editors' conflicts of interest.

Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-chain omega-3 fatty acids: a systematic review.

The polyunsaturated fatty acid composition of hepatic and plasma lipids differ by both sex and dietary fat intake in rats.

Omega-3 fatty acid supplementation does not reduce risk of atrial fibrillation after coronary artery bypass surgery: a randomized, double-blind, placebo-controlled clinical trial.

Lipid emulsions in parenteral nutrition of intensive care patients: current thinking and future directions.

Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial.

Dietary n-3 and n-6 fatty acids: are there 'bad' polyunsaturated fatty acids?

The Ninth Fatty Acids and Cell Signalling Meeting (FACS-09).

UK food standards agency workshop report: diet and immune function.

UK Food Standards Agency Workshop Report: carbohydrate and cardiovascular risk.

Sex difference in composition of plaques of patients undergoing carotid endarterectomy.

A novel effect of eicosapentaenoic acid: improved diaphragm strength in endotoxemia.

Does early exposure to long chain polyunsaturated fatty acids provide immune benefits?

Rationale and use of n-3 fatty acids in artificial nutrition.

Is there a role for fatty acids in early life programming of the immune system?

Is the demographic of British Journal of Nutrition authors changing?

β-Hydroxy-β-methylbutyrate modifies human peripheral blood mononuclear cell proliferation and cytokine production in vitro.

Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability.

Cardiovascular effects of marine omega-3 fatty acids.

Dietary free oleic and linoleic acid enhances neutrophil function and modulates the inflammatory response in rats.

BJN impact factor increases by 25%.

Lipid-laden dendritic cells fail to function.

Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters.

The American Heart Association advisory on n-6 fatty acids: evidence based or biased evidence?

Walker-256 tumor growth is inhibited by the independent or associative chronic ingestion of shark liver and fish oil: a response linked by the increment of peritoneal macrophages nitrite production in Wistar rats.

Is it prudent to add n-3 long-chain polyunsaturated fatty acids to paediatric enteral tube feeding?

Harmful, harmless or helpful? The n-6 fatty acid debate goes on.

Dietary fatty acids affect the immune system in male mice sensitized to ovalbumin or vaccinated with influenza.

Managing adult patients who need home parenteral nutrition.

Supplementation with a fish oil-enriched, high-protein medical food leads to rapid incorporation of EPA into white blood cells and modulates immune responses within one week in healthy men and women.

The impact of common gene variants on the response of biomarkers of cardiovascular disease (CVD) risk to increased fish oil fatty acids intakes.

Docosahexaenoic acid inhibits the adhesion of flowing neutrophils to cytokine stimulated human umbilical vein endothelial cells.

Does increased intake of salmon increase markers of oxidative stress in pregnant women? The salmon in pregnancy study.

More citations, but a fall in impact factor.

Fatty acids and inflammation: the cutting edge between food and pharma.

The Salmon in Pregnancy Study: study design, subject characteristics, maternal fish and marine n-3 fatty acid intake, and marine n-3 fatty acid status in maternal and umbilical cord blood.

Short-term infusion of a fish oil-based lipid emulsion modulates fatty acid status, but not immune function or (anti)oxidant balance: a randomized cross-over study.

Oral administration of oleic or linoleic acid accelerates the inflammatory phase of wound healing.

Update on the relationship of fish intake with prostate, breast, and colorectal cancers.

Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an influenza vaccination model: a randomised, double-blind, placebo-controlled study.

Salmon consumption by pregnant women reduces ex vivo umbilical cord endothelial cell activation.

Enhanced prostaglandin F2α formation in human pregnancy and the effect of increased oily fish intake: results from the Salmon in Pregnancy Study.

Dietary factors and low-grade inflammation in relation to overweight and obesity.

Fish oil supplementation improves neutrophil function during cancer chemotherapy.

Different outcomes for omega-3 heart trials: why?

Increased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 mo.

Does consumption of two portions of salmon per week enhance the antioxidant defense system in pregnant women?

β2-1 Fructans have a bifidogenic effect in healthy middle-aged human subjects but do not alter immune responses examined in the absence of an in vivo immune challenge: results from a randomised controlled trial.

Omega-3 fatty acids and inflammatory processes.

Mechanisms of action of (n-3) fatty acids.

BJN gets a new sister!

Conclusions and recommendations from the symposium, Heart Healthy Omega-3s for Food: Stearidonic Acid (SDA) as a Sustainable Choice.

Nutrition issues in Codex: health claims, nutrient reference values and WTO agreements: a conference report.

Apolipoprotein E genotype and the cardiovascular disease risk phenotype: impact of sex and adiposity (the FINGEN study).

Long-chain fatty acids and inflammation.

Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor?

Influence of yeast-derived 1,3/1,6 glucopolysaccharide on circulating cytokines and chemokines with respect to upper respiratory tract infections.

Vascular dysfunction induced in offspring by maternal dietary fat involves altered arterial polyunsaturated fatty acid biosynthesis.

Marine omega-3 fatty acids and coronary heart disease.

Variants in the genes encoding TNF-α, IL-10, and GSTP1 influence the effect of α-tocopherol on inflammatory cell responses in healthy men.

Systematic reviews of the role of omega-3 fatty acids in the prevention and treatment of disease.

Influence of marine n-3 polyunsaturated fatty acids on immune function and a systematic review of their effects on clinical outcomes in rheumatoid arthritis.

Plasma inflammatory and vascular homeostasis biomarkers increase during human pregnancy but are not affected by oily fish intake.

Oral administration of oleic or linoleic acids modulates the production of inflammatory mediators by rat macrophages.

Salmon consumption during pregnancy alters fatty acid composition and secretory IgA concentration in human breast milk.

The role of marine omega-3 (n-3) fatty acids in inflammatory processes, atherosclerosis and plaque stability.

Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?

Metabolic syndrome: epidemiology, pathophysiology, and nutrition intervention.

Lower omega-3 fatty acid intake and status are associated with poorer cognitive function in older age: A comparison of individuals with and without cognitive impairment and Alzheimer's disease.

Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish.

Record citations in 2011 contribute to maintenance of the impact factor of BJN.

The scope of the British Journal of Nutrition.

Maternal plasma phosphatidylcholine fatty acids and atopy and wheeze in the offspring at age of 6 years.

Open access, the creative commons attribution licence, and the Nutrition Society journals.

Open Access, the Creative Commons Attribution Licence, and the Nutrition Society journals.

Stearidonic acid as a supplemental source of ω-3 polyunsaturated fatty acids to enhance status for improved human health.

Maternal fat intake in rats alters 20:4n-6 and 22:6n-3 status and the epigenetic regulation of Fads2 in offspring liver.

Parenteral omega-3 fatty acids: pouring oil on troubled waters?

Immune factors and fatty acid composition in human milk from river/lake, coastal and inland regions of China.

Supplemental intravenous n-3 fatty acids and n-3 fatty acid status and outcome in critically ill elderly patients in the ICU receiving enteral nutrition.

Intravenous fish oil in hospitalized adult patients: reviewing the reviews.

Old study sheds new light on the fatty acids and cardiovascular health debate.

CD36 and SR-BI are involved in cellular uptake of provitamin A carotenoids by Caco-2 and HEK cells, and some of their genetic variants are associated with plasma concentrations of these micronutrients in humans.

Pharmaconutrition: Acute Fatty Acid Modulation of Circulating Cytokines in Elderly Patients in the ICU.

Fatty acids in plasma, white and red blood cells, and tissues after oral or intravenous administration of fish oil in rats.

Editorial: Fat chance to enhance B cell function.

Perioperative immunonutrition in well-nourished patients undergoing surgery for head and neck cancer: evaluation of inflammatory and immunologic outcomes.

Altered colonic mucosal availability of n-3 and n-6 polyunsaturated fatty acids in ulcerative colitis and the relationship to disease activity.

Unsaturated fatty acids differ between hepatic colorectal metastases and liver tissue without tumour in humans: results from a randomised controlled trial of intravenous eicosapentaenoic and docosahexaenoic acids.

Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases.

Long chain fatty acids and gene expression in inflammation and immunity.

Lipids for intravenous nutrition in hospitalised adult patients: a multiple choice of options.

n-3 fatty acids, inflammation and immunity: new mechanisms to explain old actions.

Increased consumption of salmon during pregnancy partly prevents the decline of some plasma essential amino acid concentrations in pregnant women.

Feeding the immune system.

Omega-6 and omega-3 polyunsaturated Fatty acids and allergic diseases in infancy and childhood.

Rapid Incorporation of ω-3 Fatty Acids Into Colonic Tissue After Oral Supplementation in Patients With Colorectal Cancer: A Randomized, Placebo-Controlled Intervention Trial.

Acute appearance of fatty acids in human plasma--a comparative study between polar-lipid rich oil from the microalgae Nannochloropsis oculata and krill oil in healthy young males.

Different intakes of n-3 fatty acids among pregnant women in 3 regions of China with contrasting dietary patterns are reflected in maternal but not in umbilical erythrocyte phosphatidylcholine fatty acid composition.

Monitoring immune modulation by nutrition in the general population: identifying and substantiating effects on human health.

Glucose intolerance induced by glucocorticoid excess is further impaired by co-administration with β-hydroxy-β-methylbutyrate in rats.

Age and sex differences in the incorporation of EPA and DHA into plasma fractions, cells and adipose tissue in humans.

Limited impact of 2 g/day omega-3 fatty acid ethyl esters (Omacor®) on plasma lipids and inflammatory markers in patients awaiting carotid endarterectomy.

Effect of salmon consumption during pregnancy on maternal and infant faecal microbiota, secretory IgA and calprotectin.

Metabolic benefits of marine n-3 fatty acids demonstrated in nonhuman primates.

Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease.

Altered colonic mucosal Polyunsaturated Fatty Acid (PUFA) derived lipid mediators in ulcerative colitis: new insight into relationship with disease activity and pathophysiology.

Dietary fatty acids in health and disease: greater controversy, greater interest.

Effect of oxygen tension on the amino Acid utilisation of human embryonic stem cells.