Shenyuan Zhang

The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons.

Caenorhabditis elegans TRPV ion channel regulates 5HT biosynthesis in chemosensory neurons.

STIM1, an essential and conserved component of store-operated Ca2+ channel function.

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane.

Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity.

Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai.

Molecular basis of the CRAC channel.

Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation.

Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3.

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers.

A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension.

Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells.

Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91.

The application of genome-wide RNAi screens in exploring varieties of signaling transduction pathways.