Claire T. Friel

Structural analysis of the rate-limiting transition states in the folding of Im7 and Im9: similarities and differences in the folding of homologous proteins.

Comparison of the transition state ensembles for folding of Im7 and Im9 determined using all-atom molecular dynamics simulations with phi value restraints.

Switching two-state to three-state kinetics in the helical protein Im9 via the optimisation of stabilising non-native interactions by design.

Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins.

Helix stability and hydrophobicity in the folding mechanism of the bacterial immunity protein Im9.

Semisynthesis of a glycosylated Im7 analogue for protein folding studies.

The effect of increasing the stability of non-native interactions on the folding landscape of the bacterial immunity protein Im9.

The mechanism of folding of Im7 reveals competition between functional and kinetic evolutionary constraints.

Microtubule dynamics reconstituted in vitro and imaged by single-molecule fluorescence microscopy.

Perturbing the folding energy landscape of the bacterial immunity protein Im7 by site-specific N-linked glycosylation.

Purification of tubulin from porcine brain.

Analysing the ATP turnover cycle of microtubule motors.

The kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization.

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target.

Coupling of kinesin ATP turnover to translocation and microtubule regulation: one engine, many machines.

Polo-like kinase 1 regulates the stability of the mitotic centromere-associated kinesin in mitosis.