Division of Neuropathology,
Department of Pathology,
Pathobiology Graduate Program,
Division of Neuropathology, Department of Pathology, Pathobiology Graduate Program
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Injury-induced spinal motor neuron apoptosis is preceded by DNA single-strand breaks and is p53- and Bax-dependent.
Journal of neurobiology Feb, 2002 | Pubmed ID: 11810634
Axonal transection in adult rat brain induces transsynaptic apoptosis and persistent atrophy of target neurons.
Journal of neurotrauma Jan, 2002 | Pubmed ID: 11852982
Long-term culture of mouse cortical neurons as a model for neuronal development, aging, and death.
Journal of neurobiology Apr, 2002 | Pubmed ID: 11920724
Altered expression and phosphorylation of N-methyl-D-aspartate receptors in piglet striatum after hypoxia-ischemia.
Brain research. Molecular brain research Jul, 2002 | Pubmed ID: 12117552
Immature and mature cortical neurons engage different apoptotic mechanisms involving caspase-3 and the mitogen-activated protein kinase pathway.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Aug, 2002 | Pubmed ID: 12172379
Rapid subcellular redistribution of Bax precedes caspase-3 and endonuclease activation during excitotoxic neuronal apoptosis in rat brain.
Journal of neurotrauma Jul, 2002 | Pubmed ID: 12184852
DNA base-excision repair enzyme apurinic/apyrimidinic endonuclease/redox factor-1 is increased and competent in the brain and spinal cord of individuals with amyotrophic lateral sclerosis.
Neuromolecular medicine , 2002 | Pubmed ID: 12230304
DNA damage profiling in motor neurons: a single-cell analysis by comet assay.
Neurochemical research Oct, 2002 | Pubmed ID: 12462407
Early events of target deprivation/axotomy-induced neuronal apoptosis in vivo: oxidative stress, DNA damage, p53 phosphorylation and subcellular redistribution of death proteins.
Journal of neurochemistry Apr, 2003 | Pubmed ID: 12641745
Olfactory bulb core is a rich source of neural progenitor and stem cells in adult rodent and human.
The Journal of comparative neurology May, 2003 | Pubmed ID: 12687705
Hypothermia for 24 hours after asphyxic cardiac arrest in piglets provides striatal neuroprotection that is sustained 10 days after rewarming.
Pediatric research Aug, 2003 | Pubmed ID: 12736390
Nitration of the striatal Na,K-ATPase alpha3 isoform occurs in normal brain development but is not increased during hypoxia-ischemia in newborn piglets.
Neurochemical research Dec, 2003 | Pubmed ID: 14649731
Histopathological and behavioral characterization of a novel model of cardiac arrest and cardiopulmonary resuscitation in mice.
Journal of neuroscience methods Jun, 2004 | Pubmed ID: 15126043
Neonatal mice lacking functional Fas death receptors are resistant to hypoxic-ischemic brain injury.
Neurobiology of disease Oct, 2004 | Pubmed ID: 15350969
Pluripotent fates and tissue regenerative potential of adult olfactory bulb neural stem and progenitor cells.
Journal of neurotrauma Oct, 2004 | Pubmed ID: 15672637
In situ immunoradiographic method for quantification of specific proteins in normal and ischemic brain regions.
Journal of neuroscience methods Apr, 2005 | Pubmed ID: 15814155
Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2005 | Pubmed ID: 16000635
Apoptosis in perinatal hypoxic-ischemic brain injury: how important is it and should it be inhibited?
Brain research. Brain research reviews Dec, 2005 | Pubmed ID: 16216332
Transplanted human embryonic germ cell-derived neural stem cells replace neurons and oligodendrocytes in the forebrain of neonatal mice with excitotoxic brain damage.
Journal of neuroscience research Dec, 2005 | Pubmed ID: 16247803
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2006 | Pubmed ID: 16399671
The adult neural stem and progenitor cell niche is altered in amyotrophic lateral sclerosis mouse brain.
The Journal of comparative neurology Jul, 2006 | Pubmed ID: 16736475
Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2006 | Pubmed ID: 17093100
Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death.
The Journal of comparative neurology Jan, 2007 | Pubmed ID: 17099894
Mitochondriopathy in Parkinson disease and amyotrophic lateral sclerosis.
Journal of neuropathology and experimental neurology Dec, 2006 | Pubmed ID: 17146283
Dopamine receptor modulation of hypoxic-ischemic neuronal injury in striatum of newborn piglets.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Jul, 2007 | Pubmed ID: 17213860
Transgenic mice with human mutant genes causing Parkinson's disease and amyotrophic lateral sclerosis provide common insight into mechanisms of motor neuron selective vulnerability to degeneration.
Reviews in the neurosciences , 2007 | Pubmed ID: 17593875
Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neurons.
Neurobiology of aging Oct, 2007 | Pubmed ID: 17599696
Rapid NMDA receptor phosphorylation and oxidative stress precede striatal neurodegeneration after hypoxic ischemia in newborn piglets and are attenuated with hypothermia.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience Feb, 2008 | Pubmed ID: 17950559
Adult olfactory bulb neural precursor cell grafts provide temporary protection from motor neuron degeneration, improve motor function, and extend survival in amyotrophic lateral sclerosis mice.
Journal of neuropathology and experimental neurology Nov, 2007 | Pubmed ID: 17984682
Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2008 | Pubmed ID: 18305234
DNA damage and repair: relevance to mechanisms of neurodegeneration.
Journal of neuropathology and experimental neurology May, 2008 | Pubmed ID: 18431258
Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex.
Cerebral cortex (New York, N.Y. : 1991) Jun, 2009 | Pubmed ID: 18820287
Delayed neural network degeneration after neonatal hypoxia-ischemia.
Annals of neurology Nov, 2008 | Pubmed ID: 19067347
Glycinergic innervation of motoneurons is deficient in amyotrophic lateral sclerosis mice: a quantitative confocal analysis.
The American journal of pathology Feb, 2009 | Pubmed ID: 19116365
The mitochondrial permeability transition pore in motor neurons: involvement in the pathobiology of ALS mice.
Experimental neurology Aug, 2009 | Pubmed ID: 19272377
The mitochondrial permeability transition pore: a molecular target for amyotrophic lateral sclerosis therapy.
Biochimica et biophysica acta Jan, 2010 | Pubmed ID: 19651206
Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA).
Journal of Alzheimer's disease : JAD , 2009 | Pubmed ID: 19661626
Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase/postsynaptic density-95 coupling mechanisms and protects against neonatal ischemic degeneration of striatal neurons.
Experimental neurology Jan, 2010 | Pubmed ID: 19883643
Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice.
Brain structure & function Mar, 2010 | Pubmed ID: 19888600
Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model.
Human molecular genetics Jun, 2010 | Pubmed ID: 20185556
Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice.
Human molecular genetics Jun, 2010 | Pubmed ID: 20223753
Mitochondrial pathobiology in Parkinson's disease and amyotrophic lateral sclerosis.
Journal of Alzheimer's disease : JAD , 2010 | Pubmed ID: 20413846
Necrostatin decreases oxidative damage, inflammation, and injury after neonatal HI.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Jan, 2011 | Pubmed ID: 20571523
Olesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis.
IDrugs : the investigational drugs journal Aug, 2010 | Pubmed ID: 20721828
The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target deprivation.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2011 | Pubmed ID: 21209222
Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases.
Pharmaceuticals (Basel, Switzerland) , 2010 | Pubmed ID: 21258649
An approach to experimental synaptic pathology using green fluorescent protein-transgenic mice and gene knockout mice to show mitochondrial permeability transition pore-driven excitotoxicity in interneurons and motoneurons.
Toxicologic pathology Jan, 2011 | Pubmed ID: 21378209
Glycine receptor channels in spinal motoneurons are abnormal in a transgenic mouse model of amyotrophic lateral sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2011 | Pubmed ID: 21414903
Neuronal cell death in neonatal hypoxia-ischemia.
Annals of neurology May, 2011 | Pubmed ID: 21520238
Neuroprotective effect of acid-sensing ion channel inhibitor psalmotoxin-1 after hypoxia-ischemia in newborn piglet striatum.
Neurobiology of disease Aug, 2011 | Pubmed ID: 21558004
Motoneuron subtypes show specificity in glycine receptor channel abnormalities in a transgenic mouse model of amyotrophic lateral sclerosis.
Channels (Austin, Tex.) Jul-Aug, 2011 | Pubmed ID: 21558795
Striatal neuroprotection from neonatal hypoxia-ischemia in piglets by antioxidant treatment with EUK-134 or edaravone.
Developmental neuroscience , 2011 | Pubmed ID: 21701140
Generation and characterization of transgenic mice expressing mitochondrial targeted red fluorescent protein selectively in neurons: modeling mitochondriopathy in excitotoxicity and amyotrophic lateral sclerosis.
Molecular neurodegeneration , 2011 | Pubmed ID: 22047141
Inhibitory synaptic regulation of motoneurons: a new target of disease mechanisms in amyotrophic lateral sclerosis.
Molecular neurobiology Feb, 2012 | Pubmed ID: 22072396
Mitochondrial pathobiology in ALS.
Journal of bioenergetics and biomembranes Dec, 2011 | Pubmed ID: 22083126
Epigenetic regulation of motor neuron cell death through DNA methylation.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2011 | Pubmed ID: 22090490
Nuclear localization of human SOD1 and mutant SOD1-specific disruption of survival motor neuron protein complex in transgenic amyotrophic lateral sclerosis mice.
Journal of neuropathology and experimental neurology Feb, 2012 | Pubmed ID: 22249462
Attenuation of neonatal ischemic brain damage using a 20-HETE synthesis inhibitor.
Journal of neurochemistry Apr, 2012 | Pubmed ID: 22251169
Biology of mitochondria in neurodegenerative diseases.
Progress in molecular biology and translational science , 2012 | Pubmed ID: 22482456
Programmed Necrosis: A Prominent Mechanism of Cell Death following Neonatal Brain Injury.
Neurology research international , 2012 | Pubmed ID: 22666585
Early antioxidant treatment and delayed hypothermia after hypoxia-ischemia have no additive neuroprotection in newborn pigs.
Anesthesia and analgesia Sep, 2012 | Pubmed ID: 22745113
Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Oct, 2013 | Pubmed ID: 23860373
Aberrant regulation of DNA methylation in amyotrophic lateral sclerosis: a new target of disease mechanisms.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics Oct, 2013 | Pubmed ID: 23900692
Imaging neurodegeneration in the mouse hippocampus after neonatal hypoxia-ischemia using oscillating gradient diffusion MRI.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Sep, 2014 | Pubmed ID: 24123409
The olfactory bulb in newborn piglet is a reservoir of neural stem and progenitor cells.
PloS one , 2013 | Pubmed ID: 24278384
Mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice.
Neurobiology of aging May, 2014 | Pubmed ID: 24325796
Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS.
Frontiers in cellular neuroscience , 2013 | Pubmed ID: 24399935
Skeletal muscle DNA damage precedes spinal motor neuron DNA damage in a mouse model of Spinal Muscular Atrophy (SMA).
PloS one , 2014 | Pubmed ID: 24667816
Induced Pluripotent Stem Cells from Familial Alzheimer's Disease Patients Differentiate into Mature Neurons with Amyloidogenic Properties.
Stem cells and development Aug, 2014 | Pubmed ID: 25027006
Oscillating gradient diffusion MRI reveals unique microstructural information in normal and hypoxia-ischemia injured mouse brains.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Nov, 2014 | Pubmed ID: 25168861
The non-human primate striatum undergoes marked prolonged remodeling during postnatal development.
Frontiers in cellular neuroscience , 2014 | Pubmed ID: 25294985
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