Shane R. Thomas

Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway.

Vitamin E oxidation in human atherosclerotic lesions.

The heme environment of recombinant human indoleamine 2,3-dioxygenase. Structural properties and substrate-ligand interactions.

Regulation of angiogenesis by glycogen synthase kinase-3beta.

Measurements of redox control of nitric oxide bioavailability.

Oxidative stress and endothelial nitric oxide bioactivity.

Beyond LDL oxidation: ROS in vascular signal transduction.

L-Homocysteine and L-homocystine stereospecifically induce endothelial nitric oxide synthase-dependent lipid peroxidation in endothelial cells.

Determination of the nature of the heme environment in nitrosyl indoleamine 2,3-dioxygenase using Multiple-scattering analyses of X-ray absorption fine structure.

Mitochondrial function is required for hydrogen peroxide-induced growth factor receptor transactivation and downstream signaling.

Hypochlorous acid impairs endothelium-derived nitric oxide bioactivity through a superoxide-dependent mechanism.

Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenols.

Processes involved in the site-specific effect of probucol on atherosclerosis in apolipoprotein E gene knockout mice.

Hydrogen peroxide restrains endothelium-derived nitric oxide bioactivity -- role for iron-dependent oxidative stress.

Molecules in focus: indoleamine 2,3-dioxygenase.

Post-translational regulation of human indoleamine 2,3-dioxygenase activity by nitric oxide.

Cytochrome b5, not superoxide anion radical, is a major reductant of indoleamine 2,3-dioxygenase in human cells.

Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities.

Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction.

The selenazal drug ebselen potently inhibits indoleamine 2,3-dioxygenase by targeting enzyme cysteine residues.

Kynurenine is an endothelium-derived relaxing factor produced during inflammation.

Urate as a physiological substrate for myeloperoxidase: implications for hyperuricemia and inflammation.

Flavivirus infection induces indoleamine 2,3-dioxygenase in human monocyte-derived macrophages via tumor necrosis factor and NF-κB.

Sustained expression of heme oxygenase-1 alters iron homeostasis in nonerythroid cells.

Targeted subendothelial matrix oxidation by myeloperoxidase triggers myosin II-dependent de-adhesion and alters signaling in endothelial cells.

Human indoleamine 2,3-dioxygenase is a catalyst of physiological heme peroxidase reactions: implications for the inhibition of dioxygenase activity by hydrogen peroxide.

Accumulation of serum lipids by vascular smooth muscle cells involves a macropinocytosis-like uptake pathway and is associated with the downregulation of the ATP-binding cassette transporter A1.

Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans.

Mechanism and regulation of peroxidase-catalyzed nitric oxide consumption in physiological fluids: critical protective actions of ascorbate and thiocyanate.

The freestyle aortic bioprosthesis: a systematic review.

Apolipoprotein A-I increases insulin secretion and production from pancreatic β-cells via a G-protein-cAMP-PKA-FoxO1-dependent mechanism.

Phenazine virulence factor binding to extracellular DNA is important for Pseudomonas aeruginosa biofilm formation.