SPARC Committee
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Human topoisomerase IIalpha possesses an intrinsic nucleic acid specificity for DNA ligation. Use of 5' covalently activated oligonucleotide substrates to study enzyme mechanism.
The Journal of biological chemistry Aug, 2002 | Pubmed ID: 12050172
The mechanism of topoisomerase I poisoning by a camptothecin analog.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2002 | Pubmed ID: 12426403
Regulation of site-specific recombination by the C-terminus of lambda integrase.
Nucleic acids research Dec, 2002 | Pubmed ID: 12466544
A two-drug model for etoposide action against human topoisomerase IIalpha.
The Journal of biological chemistry Feb, 2003 | Pubmed ID: 12473657
Structural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complex.
The Journal of biological chemistry Apr, 2003 | Pubmed ID: 12533542
Quinolone action against human topoisomerase IIalpha: stimulation of enzyme-mediated double-stranded DNA cleavage.
Biochemistry Apr, 2003 | Pubmed ID: 12653542
Analysis of human tyrosyl-DNA phosphodiesterase I catalytic residues.
Journal of molecular biology May, 2004 | Pubmed ID: 15111055
Mechanisms of camptothecin resistance by human topoisomerase I mutations.
Journal of molecular biology Jun, 2004 | Pubmed ID: 15165849
Design and synthesis of fluorescent substrates for human tyrosyl-DNA phosphodiesterase I.
Nucleic acids research , 2004 | Pubmed ID: 15333697
Catalytic residues of the telomere resolvase ResT: a pattern similar to, but distinct from, tyrosine recombinases and type IB topoisomerases.
The Journal of biological chemistry Dec, 2004 | Pubmed ID: 15471873
Substitution of conserved residues within the active site alters the cleavage religation equilibrium of DNA topoisomerase I.
The Journal of biological chemistry Dec, 2004 | Pubmed ID: 15489506
DNA ligation catalyzed by human topoisomerase II alpha.
Biochemistry Oct, 2004 | Pubmed ID: 15491148
Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex.
Journal of medicinal chemistry Apr, 2005 | Pubmed ID: 15801827
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1).
The Journal of biological chemistry Jun, 2005 | Pubmed ID: 15811850
Uncoupling the chemical steps of telomere resolution by ResT.
The Journal of biological chemistry Jul, 2005 | Pubmed ID: 15917226
A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex.
Molecular cancer therapeutics Feb, 2006 | Pubmed ID: 16505102
Tyrosyl-DNA phosphodiesterase (Tdp1) (3'-phosphotyrosyl DNA phosphodiesterase).
Methods in enzymology , 2006 | Pubmed ID: 16793421
Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha.
Biochemistry Apr, 2008 | Pubmed ID: 18318502
Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage.
Nucleic acids research Sep, 2008 | Pubmed ID: 18653531
Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.
Biochemistry Mar, 2009 | Pubmed ID: 19222228
Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.
Journal of medicinal chemistry Aug, 2009 | Pubmed ID: 19618939
Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha.
Biochemistry Sep, 2009 | Pubmed ID: 19697956
Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
Nature biotechnology Jan, 2010 | Pubmed ID: 20037581
A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases.
Nature Jun, 2010 | Pubmed ID: 20485342
Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV.
Nucleic acids research Jun, 2011 | Pubmed ID: 21300644
Small molecule allosteric modulators of phosphodiesterase 4.
Handbook of experimental pharmacology , 2011 | Pubmed ID: 21695640
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases.
Cell Feb, 2012 | Pubmed ID: 22304913
Artificial neural networks trained to detect viral and phage structural proteins.
PLoS computational biology , 2012 | Pubmed ID: 22927809
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2012 | Pubmed ID: 23139410
Structure and function of a cyanophage-encoded peptide deformylase.
The ISME journal Jun, 2013 | Pubmed ID: 23407310
Structural basis for the design of selective phosphodiesterase 4B inhibitors.
Cellular signalling Mar, 2014 | Pubmed ID: 24361374
Discovery of triazines as selective PDE4B versus PDE4D inhibitors.
Bioorganic & medicinal chemistry letters Aug, 2014 | Pubmed ID: 24998378
Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's disease.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics Jan, 2015 | Pubmed ID: 25371167
A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1.
PloS one , 2015 | Pubmed ID: 25909780
Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor.
Structure (London, England : 1993) May, 2015 | Pubmed ID: 26027732
Savannah E. Sanchez1,
Daniel A. Cuevas2,
Jason E. Rostron1,
Tiffany Y. Liang3,
Cullen G. Pivaroff1,
Matthew R. Haynes1,
Jim Nulton4,
Ben Felts4,
Barbara A. Bailey4,
Peter Salamon4,
Robert A. Edwards1,5,6,
Alex B. Burgin7,
Anca M. Segall1,
Forest Rohwer1
1Department of Biology, San Diego State University,
2Computational Science Research Center, San Diego State University,
3Bioinformatics and Medical Informatics Research Center, San Diego State University,
4Department of Mathematics and Statistics, San Diego State University,
5Department of Computer Science, San Diego State University,
6Mathematics and Computer Science Division, Argonne National Laboratory,
7SPARC Committee, Broad Institute
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