Department of Biology
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CLK-1 protein has DNA binding activity specific to O(L) region of mitochondrial DNA.
FEBS letters Apr, 2002 | Pubmed ID: 11959146
Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis.
The Journal of biological chemistry Oct, 2002 | Pubmed ID: 12140282
Evidence that high telomerase activity may induce a senescent-like growth arrest in human fibroblasts.
The Journal of biological chemistry Feb, 2003 | Pubmed ID: 12496279
Selectable system for monitoring the instability of CTG/CAG triplet repeats in mammalian cells.
Molecular and cellular biology Jul, 2003 | Pubmed ID: 12808091
Telomerase as a growth-promoting factor.
Cell cycle (Georgetown, Tex.) Nov-Dec, 2003 | Pubmed ID: 14504469
Phase III study of N,N-diethyl-2-[4-(phenylmethyl) phenoxy]ethanamine (BMS-217380-01) combined with doxorubicin versus doxorubicin alone in metastatic/recurrent breast cancer: National Cancer Institute of Canada Clinical Trials Group Study MA.19.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology Jan, 2004 | Pubmed ID: 14722035
DNA end joining becomes less efficient and more error-prone during cellular senescence.
Proceedings of the National Academy of Sciences of the United States of America May, 2004 | Pubmed ID: 15123826
Genome-wide demethylation destabilizes CTG.CAG trinucleotide repeats in mammalian cells.
Human molecular genetics Dec, 2004 | Pubmed ID: 15459182
Making ends meet in old age: DSB repair and aging.
Mechanisms of ageing and development Jun-Jul, 2005 | Pubmed ID: 15888314
Cell divisions are required for L1 retrotransposition.
Molecular and cellular biology Feb, 2007 | Pubmed ID: 17145770
Telomerase activity coevolves with body mass not lifespan.
Aging cell Feb, 2007 | Pubmed ID: 17173545
TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2007 | Pubmed ID: 17670947
Changes in the level and distribution of Ku proteins during cellular senescence.
DNA repair Dec, 2007 | Pubmed ID: 17686666
Changes in DNA repair during aging.
Nucleic acids research , 2007 | Pubmed ID: 17913742
Genome-wide demethylation promotes triplet repeat instability independently of homologous recombination.
DNA repair Feb, 2008 | Pubmed ID: 18083071
Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial.
Lancet Dec, 2007 | Pubmed ID: 18156031
Coevolution of telomerase activity and body mass in mammals: from mice to beavers.
Mechanisms of ageing and development Jan-Feb, 2009 | Pubmed ID: 18387652
Comparison of nonhomologous end joining and homologous recombination in human cells.
DNA repair Oct, 2008 | Pubmed ID: 18675941
DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells.
Cell cycle (Georgetown, Tex.) Sep, 2008 | Pubmed ID: 18769152
Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan.
Aging cell Dec, 2008 | Pubmed ID: 18778411
Use of the Rad51 promoter for targeted anti-cancer therapy.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2008 | Pubmed ID: 19106292
Rodents for comparative aging studies: from mice to beavers.
Age (Dordrecht, Netherlands) Sep, 2008 | Pubmed ID: 19424861
DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells.
Neoplasia (New York, N.Y.) Jul, 2009 | Pubmed ID: 19568413
Doxorubicin and paclitaxel versus fluorouracil, doxorubicin and cyclophosphamide as first-line therapy for women with advanced breast cancer: long-term analysis of the previously published trial.
Onkologie Sep, 2009 | Pubmed ID: 19745590
Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2009 | Pubmed ID: 19858485
Multicenter phase III comparison of cisplatin/S-1 with cisplatin/infusional fluorouracil in advanced gastric or gastroesophageal adenocarcinoma study: the FLAGS trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology Mar, 2010 | Pubmed ID: 20159816
SIRT6 promotes DNA repair under stress by activating PARP1.
Science (New York, N.Y.) Jun, 2011 | Pubmed ID: 21680843
SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells.
Cell cycle (Georgetown, Tex.) Sep, 2011 | Pubmed ID: 21900744
Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair.
Aging Sep, 2011 | Pubmed ID: 21946623
Rad51 promoter-targeted gene therapy is effective for in vivo visualization and treatment of cancer.
Molecular therapy : the journal of the American Society of Gene Therapy Feb, 2012 | Pubmed ID: 22008909
Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial.
Lancet Dec, 2011 | Pubmed ID: 22056247
Safety and efficacy of first-line bevacizumab plus chemotherapy in elderly patients with advanced or recurrent nonsquamous non-small cell lung cancer: safety of avastin in lung trial (MO19390).
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer Jan, 2012 | Pubmed ID: 22173662
Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells.
PloS one , 2011 | Pubmed ID: 22174876
SIRT1 as a therapeutic target in inflammaging of the pulmonary disease.
Preventive medicine Dec, 2011 | Pubmed ID: 22178470
Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients of different ethnic origins.
Pharmacogenomics Jan, 2012 | Pubmed ID: 22188361
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