Laurent Kremer

The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation.

Re-emergence of tuberculosis: strategies and treatment.

Immunoregulatory functions of interleukin 18 and its role in defense against bacterial pathogens.

Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis.

Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis.

Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis.

The methyl-branched fortifications of Mycobacterium tuberculosis.

Structural study of lipomannan and lipoarabinomannan from Mycobacterium chelonae. Presence of unusual components with alpha 1,3-mannopyranose side chains.

Current status and future development of antitubercular chemotherapy.

Temperature-induced changes in the cell-wall components of Mycobacterium thermoresistibile.

Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis.

Mycobacterium bovis BCG producing interleukin-18 increases antigen-specific gamma interferon production in mice.

Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria.

Immune response induced by recombinant Mycobacterium bovis BCG producing the cholera toxin B subunit.

Lipomannan and lipoarabinomannan from a clinical isolate of Mycobacterium kansasii: novel structural features and apoptosis-inducing properties.

Lipomannans, but not lipoarabinomannans, purified from Mycobacterium chelonae and Mycobacterium kansasii induce TNF-alpha and IL-8 secretion by a CD14-toll-like receptor 2-dependent mechanism.

Protein PknE, a novel transmembrane eukaryotic-like serine/threonine kinase from Mycobacterium tuberculosis.

Crystallization and preliminary X-ray diffraction data of Mycobacterium tuberculosis FbpC1 (Rv3803c).

The structure of Mycobacterium tuberculosis MPT51 (FbpC1) defines a new family of non-catalytic alpha/beta hydrolases.

An FHA phosphoprotein recognition domain mediates protein EmbR phosphorylation by PknH, a Ser/Thr protein kinase from Mycobacterium tuberculosis.

Toll-like receptor 2 (TLR2)-dependent-positive and TLR2-independent-negative regulation of proinflammatory cytokines by mycobacterial lipomannans.

The use of microarray analysis to determine the gene expression profiles of Mycobacterium tuberculosis in response to anti-bacterial compounds.

Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.

Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria.

Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.

Identification and structural characterization of an unusual mycobacterial monomeromycolyl-diacylglycerol.

Mycobacterial lipomannan induces matrix metalloproteinase-9 expression in human macrophagic cells through a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent mechanism.

LosA, a key glycosyltransferase involved in the biosynthesis of a novel family of glycosylated acyltrehalose lipooligosaccharides from Mycobacterium marinum.

Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis.

GroEL1: a dedicated chaperone involved in mycolic acid biosynthesis during biofilm formation in mycobacteria.

Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis.

Dual inhibition of mycobacterial fatty acid biosynthesis and degradation by 2-alkynoic acids.

pH-dependent pore-forming activity of OmpATb from Mycobacterium tuberculosis and characterization of the channel by peptidic dissection.

Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.

X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB).

EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets.

Mycobacterial lipomannan induces granuloma macrophage fusion via a TLR2-dependent, ADAM9- and beta1 integrin-mediated pathway.

Identification by surface plasmon resonance of the mycobacterial lipomannan and lipoarabinomannan domains involved in binding to CD14 and LPS-binding protein.

Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice.

Polysaccharide structural variability in mycobacteria: identification and characterization of phosphorylated mannan and arabinomannan.

The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development.

The N-terminal domain of OmpATb is required for membrane translocation and pore-forming activity in mycobacteria.

Structure of Mycobacterium tuberculosis mtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT).

Functional role of the PE domain and immunogenicity of the Mycobacterium tuberculosis triacylglycerol hydrolase LipY.

EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR.

Antimycobacterial Activity and Mechanism of Action of NAS-91.

Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria.

The Mycobacterium tuberculosis serine/threonine kinase PknL phosphorylates Rv2175c: mass spectrometric profiling of the activation loop phosphorylation sites and their role in the recruitment of Rv2175c.

Mycobacterial lipomannan induces MAP kinase phosphatase-1 expression in macrophages.

Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis.

From the characterization of the four serine/threonine protein kinases (PknA/B/G/L) of Corynebacterium glutamicum toward the role of PknA and PknB in cell division.

Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria.

pETPhos: a customized expression vector designed for further characterization of Ser/Thr/Tyr protein kinases and their substrates.

TLR2-dependent eosinophil interactions with mycobacteria: role of alpha-defensins.

The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.

The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue.

Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis.

The Mycobacterium tuberculosis GroEL1 chaperone is a substrate of Ser/Thr protein kinases.

Dynamic and structural characterization of a bacterial FHA protein reveals a new autoinhibition mechanism.

The Mycobacterium tuberculosis Ser/Thr kinase substrate Rv2175c is a DNA-binding protein regulated by phosphorylation.

Mycobacterium marinum lipooligosaccharides are unique caryophyllose-containing cell wall glycolipids that inhibit tumor necrosis factor-alpha secretion in macrophages.

Oleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target.

Phosphorylation of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA regulates mycolic acid biosynthesis.

Enzymatic hydrolysis of trehalose dimycolate releases free mycolic acids during mycobacterial growth in biofilms.

Temperature-dependent regulation of mycolic acid cyclopropanation in saprophytic mycobacteria: role of the Mycobacterium smegmatis 1351 gene (MSMEG_1351) in CIS-cyclopropanation of alpha-mycolates.

Division and cell envelope regulation by Ser/Thr phosphorylation: Mycobacterium shows the way.

An improved method to unravel phosphoacceptors in Ser/Thr protein kinase-phosphorylated substrates.

Structural analysis of an unusual bioactive N-acylated lipo-oligosaccharide LOS-IV in Mycobacterium marinum.

Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis.

Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives.

A Mycobacterium marinum TesA mutant defective for major cell wall-associated lipids is highly attenuated in Dictyostelium discoideum and zebrafish embryos.

Synthesis and in vitro antitubercular activity of ferrocene-based hydrazones.

Expression of OmpATb is dependent on small membrane proteins in Mycobacterium bovis BCG.

Fatty acyl chains of Mycobacterium marinum lipooligosaccharides: structure, localization and acylation by PapA4 (MMAR_2343) protein.

Negative regulation by Ser/Thr phosphorylation of HadAB and HadBC dehydratases from Mycobacterium tuberculosis type II fatty acid synthase system.

Mycobacterium tuberculosis lipolytic enzymes as potential biomarkers for the diagnosis of active tuberculosis.

AccD6, a key carboxyltransferase essential for mycolic acid synthesis in Mycobacterium tuberculosis, is dispensable in a nonpathogenic strain.

Exposure of mycobacteria to cell wall-inhibitory drugs decreases the production of an arabinoglycerolipid related to mycolyl-arabinogalactan-peptidoglycan metabolism.

CR3-dependent negative regulation of human eosinophils by Mycobacterium bovis BCG lipoarabinomannan.

Synthesis and in vitro anti-tubercular evaluation of 1,2,3-triazole tethered β-lactam-ferrocene and β-lactam-ferrocenylchalcone chimeric scaffolds.

Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.

Phosphorylation of mycobacterial PcaA inhibits mycolic acid cyclopropanation: consequences for intracellular survival and for phagosome maturation block.

Structural determination and Toll-like receptor 2-dependent proinflammatory activity of dimycolyl-diarabino-glycerol from Mycobacterium marinum.

Identification of the Mycobacterium marinum Apa antigen O-mannosylation sites reveals important glycosylation variability with the M. tuberculosis Apa homologue.

The C-terminal domain of the virulence factor MgtC is a divergent ACT domain.

MmPPOX inhibits Mycobacterium tuberculosis lipolytic enzymes belonging to the hormone-sensitive lipase family and alters mycobacterial growth.

Azide-alkyne cycloaddition en route towards 1H-1,2,3-triazole-tethered β-lactam-ferrocene and β-lactam-ferrocenylchalcone conjugates: synthesis and in vitro anti-tubercular evaluation.

Point mutations within the fatty acid synthase type II dehydratase components HadA or HadC contribute to isoxyl resistance in Mycobacterium tuberculosis.

Exposure to a cutinase-like serine esterase triggers rapid lysis of multiple mycobacterial species.

Mycobacterium tuberculosis S-adenosyl-l-homocysteine hydrolase is negatively regulated by Ser/Thr phosphorylation.

Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues.

Montpellier Infectious Diseases (MID), 2nd annual meeting (2012).

Overexpression of the KdpF membrane peptide in Mycobacterium bovis BCG results in reduced intramacrophage growth and altered cording morphology.

Mycobacterium tuberculosis maltosyltransferase GlgE, a genetically validated antituberculosis target, is negatively regulated by Ser/Thr phosphorylation.

Keto-mycolic acid-dependent pellicle formation confers tolerance to drug-sensitive Mycobacterium tuberculosis.

Identification and characterisation of small-molecule inhibitors of Rv3097c-encoded lipase (LipY) of Mycobacterium tuberculosis that selectively inhibit growth of bacilli in hypoxia.

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis.

4-Aminoquinoline-β-lactam conjugates: synthesis, antimalarial, and antitubercular evaluation.

Increased phagocytosis of Mycobacterium marinum mutants defective in lipooligosaccharide production: a structure-activity relationship study.

7-chloroquinoline-isatin conjugates: antimalarial, antitubercular, and cytotoxic evaluation.

Mycobacterium abscessus cording prevents phagocytosis and promotes abscess formation.

Acetic Acid, the active component of vinegar, is an effective tuberculocidal disinfectant.

The Mycobacterium tuberculosis transcriptional repressor EthR is negatively regulated by Serine/Threonine phosphorylation.

In vivo assessment of drug efficacy against Mycobacterium abscessus using the embryonic zebrafish test system.

Phosphorylation of KasB regulates virulence and acid-fastness in Mycobacterium tuberculosis.

[Mycobacterial cording: a new mechanism of immune evasion?].

Design, synthesis and docking studies of some novel (R)-2-(4'-chlorophenyl)-3-(4'-nitrophenyl)-1,2,3,5-tetrahydrobenzo[4,5] imidazo [1,2-c]pyrimidin-4-ol derivatives as antitubercular agents.

Overexpression of the Salmonella KdpF membrane peptide modulates expression of kdp genes and intramacrophage growth.

β-Lactamase inhibition by avibactam in Mycobacterium abscessus.

Mycobacterium marinum MgtC Plays a Role in Phagocytosis but is Dispensable for Intracellular Multiplication.

Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies.

Neural correlates of visual hallucinations in dementia with Lewy bodies.

A new dehydratase conferring innate resistance to thiacetazone and intra-amoebal survival of Mycobacterium smegmatis.

The Molecular Genetics of Mycolic Acid Biosynthesis.

[Looking through zebrafish to study host-pathogen interactions].