Department of Neurology,
Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology,
Center for Regenerative Medicine,
Neuroregeneration,
Center for Regenerative Medicine, Neuroregeneration
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Pathophysiology of catalytic antibodies.
Immunology letters Feb, 2006 | Pubmed ID: 16427704
Physiopathology of catalytic antibodies: the case for factor VIII-hydrolyzing immunoglobulin G.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Jun, 2006 | Pubmed ID: 16651863
Catalytic IgG from patients with hemophilia A inactivate therapeutic factor VIII.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2006 | Pubmed ID: 16818797
VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors.
Blood Jan, 2007 | Pubmed ID: 16985172
Immune response against therapeutic factor VIII in hemophilia A patients--a survey of probable risk factors.
Immunology letters May, 2007 | Pubmed ID: 17467813
A role for exposed mannosylations in presentation of human therapeutic self-proteins to CD4+ T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America May, 2007 | Pubmed ID: 17502612
Molecular characterization of human B domain-specific anti-factor VIII monoclonal antibodies generated in transgenic mice.
Thrombosis and haemostasis Jul, 2007 | Pubmed ID: 17598006
Factor VIII bypasses CD91/LRP for endocytosis by dendritic cells leading to T-cell activation.
Haematologica Jan, 2008 | Pubmed ID: 18166789
Factor VIII hydrolysis mediated by anti-factor VIII autoantibodies in acquired hemophilia.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2008 | Pubmed ID: 18490775
Hydrolysis of coagulation factors by circulating IgG is associated with a reduced risk for chronic allograft nephropathy in renal transplanted patients.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2008 | Pubmed ID: 18523313
Varied immune response to FVIII: presence of proteolytic antibodies directed to factor VIII in different human pathologies.
Clinical reviews in allergy & immunology Oct, 2009 | Pubmed ID: 19160072
Factor VIII-hydrolyzing IgG in acquired and congenital hemophilia.
FEBS letters Aug, 2009 | Pubmed ID: 19595998
NHE4 is critical for the renal handling of ammonia in rodents.
The Journal of clinical investigation Jun, 2010 | Pubmed ID: 20484819
Tissue kallikrein permits early renal adaptation to potassium load.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2010 | Pubmed ID: 20624970
Catalytic antibodies and severe sepsis.
Discovery medicine Apr, 2005 | Pubmed ID: 20704912
Intravenous immunoglobulin induces proliferation and immunoglobulin synthesis from B cells of patients with common variable immunodeficiency: a mechanism underlying the beneficial effect of IVIg in primary immunodeficiencies.
Journal of autoimmunity Feb, 2011 | Pubmed ID: 20970960
Proteolytic antibodies activate factor IX in patients with acquired hemophilia.
Blood Feb, 2011 | Pubmed ID: 21131590
Autoantibodies with enzymatic properties in human autoimmune diseases.
Journal of autoimmunity Sep, 2011 | Pubmed ID: 21624820
Evidence for the role of B cells and immunoglobulins in the pathogenesis of multiple sclerosis.
Neurology research international , 2011 | Pubmed ID: 21961063
Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosis.
Brain pathology (Zurich, Switzerland) Sep, 2012 | Pubmed ID: 22335434
Need for a paradigm shift in therapeutic approaches to CNS injury.
Expert review of neurotherapeutics Apr, 2012 | Pubmed ID: 22449213
Is multiple sclerosis an autoimmune disease?
Autoimmune diseases , 2012 | Pubmed ID: 22666554
High-affinity binding of remyelinating natural autoantibodies to myelin-mimicking lipid bilayers revealed by nanohole surface plasmon resonance.
Analytical chemistry Jul, 2012 | Pubmed ID: 22762372
PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor.
The Journal of clinical investigation Sep, 2012 | Pubmed ID: 22886306
The road to remyelination in demyelinating diseases: current status and prospects for clinical treatment.
Expert review of clinical immunology Jun, 2013 | Pubmed ID: 23730884
CD8(+) T cells in multiple sclerosis.
Expert opinion on therapeutic targets Sep, 2013 | Pubmed ID: 23829711
IVIg treatment reduces catalytic antibody titers of renal transplanted patients.
PloS one , 2013 | Pubmed ID: 23967092
Polyclonal and monoclonal antibodies in clinic.
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 24037837
Cellular targets and mechanistic strategies of remyelination-promoting IgMs as part of the naturally occurring autoantibody repertoire.
Expert review of neurotherapeutics Sep, 2013 | Pubmed ID: 24053345
Applications of SPR for the characterization of molecules important in the pathogenesis and treatment of neurodegenerative diseases.
Expert review of neurotherapeutics Apr, 2014 | Pubmed ID: 24625008
Deletion of Virus-specific T-cells Enhances Remyelination in a Model of Multiple Sclerosis.
Journal of neurology & translational neuroscience 1, 2014 | Pubmed ID: 25383388
Quantitative PCR analysis of DNA aptamer pharmacokinetics in mice.
Nucleic acid therapeutics Feb, 2015 | Pubmed ID: 25536292
Polysialic acid as an antigen for monoclonal antibody HIgM12 to treat multiple sclerosis and other neurodegenerative disorders.
Journal of neurochemistry Sep, 2015 | Pubmed ID: 25866077
A single dose of a neuron-binding human monoclonal antibody improves brainstem NAA concentrations, a biomarker for density of spinal cord axons, in a model of progressive multiple sclerosis.
Journal of neuroinflammation , 2015 | Pubmed ID: 25924771
Abbreviated exposure to hypoxia is sufficient to induce CNS dysmyelination, modulate spinal motor neuron composition, and impair motor development in neonatal mice.
PloS one , 2015 | Pubmed ID: 26020269
A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis.
Disease models & mechanisms Aug, 2015 | Pubmed ID: 26035393
Naturally Occurring Monoclonal Antibodies and Their Therapeutic Potential for Neurologic Diseases.
JAMA neurology Nov, 2015 | Pubmed ID: 26389734
Antibody-Mediated Oligodendrocyte Remyelination Promotes Axon Health in Progressive Demyelinating Disease.
Molecular neurobiology Sep, 2015 | Pubmed ID: 26409478
Tryptophan Metabolites and Their Impact on Multiple Sclerosis Progression.
Current pharmaceutical design Dec, 2015 | Pubmed ID: 26667001
Tryptophan Catabolites and Their Impact on Multiple Sclerosis Progression.
Current pharmaceutical design , 2016 | Pubmed ID: 26899126
Recent Advances in Monoclonal Antibody Therapies for Multiple Sclerosis.
Expert opinion on biological therapy Jun, 2016 | Pubmed ID: 26914737
Generation of Catalytic Antibodies Is an Intrinsic Property of an Individual's Immune System: A Study on a Large Cohort of Renal Transplant Patients.
Journal of immunology (Baltimore, Md. : 1950) May, 2016 | Pubmed ID: 27067006
A monoclonal natural human IgM protects axons in the absence of remyelination.
Journal of neuroinflammation , 2016 | Pubmed ID: 27126523
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