Department of Electrical Engineering and Computer Science,
Department of Biological Engineering,
Department of Electrical Engineering and Computer Science, Department of Biological Engineering
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Characterization and optimization of an entropic trap for DNA separation.
Analytical chemistry Jan, 2002 | Pubmed ID: 11811414
Two-dimensional protein separation with advanced sample and buffer isolation using microfluidic valves.
Analytical chemistry Aug, 2004 | Pubmed ID: 15283583
Rapid protein separations in ultra-short microchannels: microchip sodium dodecyl sulfate-polyacrylamide gel electrophoresis and isoelectric focusing.
Journal of chromatography. A Sep, 2004 | Pubmed ID: 15499934
Million-fold preconcentration of proteins and peptides by nanofluidic filter.
Analytical chemistry Jul, 2005 | Pubmed ID: 16013838
Fabrication and characterization of 20 nm planar nanofluidic channels by glass-glass and glass-silicon bonding.
Lab on a chip Aug, 2005 | Pubmed ID: 16027934
Continuous-flow pI-based sorting of proteins and peptides in a microfluidic chip using diffusion potential.
Analytical chemistry Jun, 2006 | Pubmed ID: 16737204
Molecular sieving in periodic free-energy landscapes created by patterned nanofilter arrays.
Physical review letters Jul, 2006 | Pubmed ID: 16907412
Electrohydrodynamic generation and delivery of monodisperse picoliter droplets using a poly(dimethylsiloxane) microchip.
Analytical chemistry Dec, 2006 | Pubmed ID: 17134134
Biomolecule separation by steric hindrance using nanofluidic filters.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference , 2004 | Pubmed ID: 17270810
Patterning of proteins and cells on functionalized surfaces prepared by polyelectrolyte multilayers and micromolding in capillaries.
Biosensors & bioelectronics Jun, 2007 | Pubmed ID: 17400439
Poly(dimethylsiloxane)-based protein preconcentration using a nanogap generated by junction gap breakdown.
Analytical chemistry Sep, 2007 | Pubmed ID: 17628080
Concentration polarization and nonlinear electrokinetic flow near a nanofluidic channel.
Physical review letters Jul, 2007 | Pubmed ID: 17678369
Electrical detection of fast reaction kinetics in nanochannels with an induced flow.
Nano letters Dec, 2007 | Pubmed ID: 17997589
Molecular sieving using nanofilters: past, present and future.
Lab on a chip Jan, 2008 | Pubmed ID: 18094759
Continuum transport model of Ogston sieving in patterned nanofilter arrays for separation of rod-like biomolecules.
Electrophoresis Jan, 2008 | Pubmed ID: 18203240
Pre-binding dynamic range and sensitivity enhancement for immuno-sensors using nanofluidic preconcentrator.
Lab on a chip Mar, 2008 | Pubmed ID: 18305855
Increase of reaction rate and sensitivity of low-abundance enzyme assay using micro/nanofluidic preconcentration chip.
Analytical chemistry May, 2008 | Pubmed ID: 18358012
Multiplexed proteomic sample preconcentration device using surface-patterned ion-selective membrane.
Lab on a chip Apr, 2008 | Pubmed ID: 18369515
Self-sealed vertical polymeric nanoporous-junctions for high-throughput nanofluidic applications.
Analytical chemistry May, 2008 | Pubmed ID: 18380489
Artificial molecular sieves and filters: a new paradigm for biomolecule separation.
Trends in biotechnology Jun, 2008 | Pubmed ID: 18430480
A patterned anisotropic nanofluidic sieving structure for continuous-flow separation of DNA and proteins.
Nature nanotechnology Feb, 2007 | Pubmed ID: 18654231
Simulation of DNA electrophoresis in systems of large number of solvent particles by coarse-grained hybrid molecular dynamics approach.
Journal of computational chemistry Mar, 2009 | Pubmed ID: 18773412
A Nanofilter Array Chip for Fast Gel-Free Biomolecule Separation.
Applied physics letters Dec, 2005 | Pubmed ID: 18846250
Decreasing effective nanofluidic filter size by modulating electrical double layers: separation enhancement in microfabricated nanofluidic filters.
Electrophoresis Dec, 2008 | Pubmed ID: 19016242
Transport of biomolecules in asymmetric nanofilter arrays.
Analytical and bioanalytical chemistry May, 2009 | Pubmed ID: 19127359
Realistic simulations of combined DNA electrophoretic flow and EOF in nano-fluidic devices.
Electrophoresis Dec, 2008 | Pubmed ID: 19130595
Massively-parallel ultra-high-aspect-ratio nanochannels as mesoporous membranes.
Lab on a chip Feb, 2009 | Pubmed ID: 19190794
Amplified electrokinetic response by concentration polarization near nanofluidic channel.
Langmuir : the ACS journal of surfaces and colloids Jul, 2009 | Pubmed ID: 19358584
Rapid quantification of disease-marker proteins using continuous-flow immunoseparation in a nanosieve fluidic device.
Analytical chemistry Aug, 2009 | Pubmed ID: 19627123
Microfluidic concentration-enhanced cellular kinase activity assay.
Journal of the American Chemical Society Aug, 2009 | Pubmed ID: 19722608
Continuous-flow bioseparation using microfabricated anisotropic nanofluidic sieving structures.
Nature protocols , 2009 | Pubmed ID: 19876028
Analytical description of Ogston-regime biomolecule separation using nanofilters and nanopores.
Physical review. E, Statistical, nonlinear, and soft matter physics Oct, 2009 | Pubmed ID: 19905346
Stabilization of ion concentration polarization using a heterogeneous nanoporous junction.
Nano letters Jan, 2010 | Pubmed ID: 20017532
Free-flow zone electrophoresis of peptides and proteins in PDMS microchip for narrow pI range sample prefractionation coupled with mass spectrometry.
Analytical chemistry Mar, 2010 | Pubmed ID: 20163146
Nanofluidic concentration devices for biomolecules utilizing ion concentration polarization: theory, fabrication, and applications.
Chemical Society reviews Mar, 2010 | Pubmed ID: 20179814
Direct seawater desalination by ion concentration polarization.
Nature nanotechnology Apr, 2010 | Pubmed ID: 20305644
Increasing the sensitivity of enzyme-linked immunosorbent assay using multiplexed electrokinetic concentrator.
Analytical chemistry Apr, 2010 | Pubmed ID: 20307052
Microfluidics for cell separation.
Medical & biological engineering & computing Oct, 2010 | Pubmed ID: 20414811
Capillary-valve-based fabrication of ion-selective membrane junction for electrokinetic sample preconcentration in PDMS chip.
Lab on a chip Jun, 2010 | Pubmed ID: 20480116
Deformability based cell margination--a simple microfluidic design for malaria-infected erythrocyte separation.
Lab on a chip Oct, 2010 | Pubmed ID: 20689864
Micro and nanotechnology for biological and biomedical applications.
Medical & biological engineering & computing Oct, 2010 | Pubmed ID: 20844973
Concentration-enhanced rapid detection of human chorionic gonadotropin (hCG) on a Au surface using a nanofluidic preconcentrator.
Microfluidics and nanofluidics Oct, 2010 | Pubmed ID: 20953263
Shape and Biomechanical Characteristics of Human Red Blood Cells in Health and Disease.
MRS bulletin / Materials Research Society May, 2010 | Pubmed ID: 21151848
A microfabricated deformability-based flow cytometer with application to malaria.
Lab on a chip Mar, 2011 | Pubmed ID: 21293801
Massively parallel concentration device for multiplexed immunoassays.
Lab on a chip Apr, 2011 | Pubmed ID: 21321747
High-throughput cell cycle synchronization using inertial forces in spiral microchannels.
Lab on a chip Apr, 2011 | Pubmed ID: 21336340
Dispersive transport of biomolecules in periodic energy landscapes with application to nanofilter sieving arrays.
Electrophoresis Feb, 2011 | Pubmed ID: 21341285
Pinched flow coupled shear-modulated inertial microfluidics for high-throughput rare blood cell separation.
Lab on a chip Jun, 2011 | Pubmed ID: 21505682
Enhancing protease activity assay in droplet-based microfluidics using a biomolecule concentrator.
Journal of the American Chemical Society Jul, 2011 | Pubmed ID: 21671557
Non-linear and linear enhancement of enzymatic reaction kinetics using a biomolecule concentrator.
Lab on a chip Aug, 2011 | Pubmed ID: 21677981
Continuous signal enhancement for sensitive aptamer affinity probe electrophoresis assay using electrokinetic concentration.
Analytical chemistry Sep, 2011 | Pubmed ID: 21809885
Continuous-flow biomolecule and cell concentrator by ion concentration polarization.
Analytical chemistry Oct, 2011 | Pubmed ID: 21854051
Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes.
Nature materials Dec, 2011 | Pubmed ID: 22019944
Adhesive-based liquid metal radio-frequency microcoil for magnetic resonance relaxometry measurement.
Lab on a chip Jan, 2012 | Pubmed ID: 22116258
Layer-by-layer deposition of all-nanoparticle multilayers in confined geometries.
ACS applied materials & interfaces Jan, 2012 | Pubmed ID: 22181001
A microfluidics approach towards high-throughput pathogen removal from blood using margination.
Biomicrofluidics Jun, 2012 | Pubmed ID: 22655023
Nanotechnology in plastic surgery.
Plastic and reconstructive surgery Dec, 2012 | Pubmed ID: 22878482
A microfluidic in vitro system for the quantitative study of the stomach mucus barrier function.
Lab on a chip Oct, 2012 | Pubmed ID: 22878692
Nanofluidic preconcentration device in a straight microchannel using ion concentration polarization.
Lab on a chip Nov, 2012 | Pubmed ID: 22907316
Pf155/RESA protein influences the dynamic microcirculatory behavior of ring-stage Plasmodium falciparum infected red blood cells.
Scientific reports , 2012 | Pubmed ID: 22937223
Continuous-flow biomolecule concentration and detection in a slanted nanofilter array.
Lab on a chip Nov, 2012 | Pubmed ID: 22955573
Development of miniaturized, portable magnetic resonance relaxometry system for point-of-care medical diagnosis.
The Review of scientific instruments Sep, 2012 | Pubmed ID: 23020427
Separation of leukocytes from blood using spiral channel with trapezoid cross-section.
Analytical chemistry Nov, 2012 | Pubmed ID: 23025404
Multi-vortical flow inducing electrokinetic instability in ion concentration polarization layer.
Nanoscale Dec, 2012 | Pubmed ID: 23085964
Multiplexed protease activity assay for low-volume clinical samples using droplet-based microfluidics and its application to endometriosis.
Journal of the American Chemical Society Feb, 2013 | Pubmed ID: 23157326
Direct numerical simulation of electroconvective instability and hysteretic current-voltage response of a permselective membrane.
Physical review. E, Statistical, nonlinear, and soft matter physics Oct, 2012 | Pubmed ID: 23214680
Tunable ionic transport for a triangular nanochannel in a polymeric nanofluidic system.
ACS nano Jan, 2013 | Pubmed ID: 23244067
Dynamic deformability of Plasmodium falciparum-infected erythrocytes exposed to artesunate in vitro.
Integrative biology : quantitative biosciences from nano to macro Feb, 2013 | Pubmed ID: 23254624
Isolation and retrieval of circulating tumor cells using centrifugal forces.
Scientific reports , 2013 | Pubmed ID: 23405273
Isoporous micro/nanoengineered membranes.
ACS nano Mar, 2013 | Pubmed ID: 23442009
Spiral microchannel with rectangular and trapezoidal cross-sections for size based particle separation.
Scientific reports , 2013 | Pubmed ID: 23502529
ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling.
Proceedings of the National Academy of Sciences of the United States of America May, 2013 | Pubmed ID: 23674691
Slanted spiral microfluidics for the ultra-fast, label-free isolation of circulating tumor cells.
Lab on a chip Jan, 2014 | Pubmed ID: 23949794
Spatial configuration and composition of charge modulates transport into a mucin hydrogel barrier.
Biophysical journal Sep, 2013 | Pubmed ID: 24047986
Tunable membranes for free-flow zone electrophoresis in PDMS microchip using guided self-assembly of silica microbeads.
Analytical chemistry Dec, 2013 | Pubmed ID: 24251795
Microfabricated nerve-electrode interfaces in neural prosthetics and neural engineering.
Biotechnology & genetic engineering reviews , 2013 | Pubmed ID: 24568276
Microfluidic probe for single-cell analysis in adherent tissue culture.
Nature communications , 2014 | Pubmed ID: 24594667
In vivo splenic clearance correlates with in vitro deformability of red blood cells from Plasmodium yoelii-infected mice.
Infection and immunity Jun, 2014 | Pubmed ID: 24686065
An ultra-high-throughput spiral microfluidic biochip for the enrichment of circulating tumor cells.
The Analyst Jul, 2014 | Pubmed ID: 24840240
Clinical validation of an ultra high-throughput spiral microfluidics for the detection and enrichment of viable circulating tumor cells.
PloS one , 2014 | Pubmed ID: 24999991
Detecting kinase activities from single cell lysate using concentration-enhanced mobility shift assay.
Analytical chemistry Aug, 2014 | Pubmed ID: 25025773
Direct in vivo electrochemical detection of haemoglobin in red blood cells.
Scientific reports , 2014 | Pubmed ID: 25163492
Shear flow of an electrically charged fluid by ion concentration polarization: scaling laws for electroconvective vortices.
Physical review letters Mar, 2013 | Pubmed ID: 25166542
Micromagnetic resonance relaxometry for rapid label-free malaria diagnosis.
Nature medicine Sep, 2014 | Pubmed ID: 25173428
Multivariate biophysical markers predictive of mesenchymal stromal cell multipotency.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2014 | Pubmed ID: 25298531
Towards microfluidic-based depletion of stiff and fragile human red cells that accumulate during blood storage.
Lab on a chip Jan, 2015 | Pubmed ID: 25406942
Bone marrow regeneration promoted by biophysically sorted osteoprogenitors from mesenchymal stromal cells.
Stem cells translational medicine Jan, 2015 | Pubmed ID: 25411477
Jetting microfluidics with size-sorting capability for single-cell protease detection.
Biosensors & bioelectronics Apr, 2015 | Pubmed ID: 25460876
Malaria detection using inertial microfluidics.
Lab on a chip Feb, 2015 | Pubmed ID: 25537768
Capacitive deionization on-chip as a method for microfluidic sample preparation.
Lab on a chip Mar, 2015 | Pubmed ID: 25607349
Enhanced transport of materials into enamel nanopores via electrokinetic flow.
Journal of dental research Apr, 2015 | Pubmed ID: 25691072
High-throughput protease activity cytometry reveals dose-dependent heterogeneity in PMA-mediated ADAM17 activation.
Integrative biology : quantitative biosciences from nano to macro May, 2015 | Pubmed ID: 25832727
Direct detection and drug-resistance profiling of bacteremias using inertial microfluidics.
Lab on a chip May, 2015 | Pubmed ID: 25882432
Enhancing malaria diagnosis through microfluidic cell enrichment and magnetic resonance relaxometry detection.
Scientific reports , 2015 | Pubmed ID: 26081638
Identification of malaria parasite-infected red blood cell surface aptamers by inertial microfluidic SELEX (I-SELEX).
Scientific reports , 2015 | Pubmed ID: 26126714
Membrane-less microfiltration using inertial microfluidics.
Scientific reports , 2015 | Pubmed ID: 26154774
Large-Volume Microfluidic Cell Sorting for Biomedical Applications.
Annual review of biomedical engineering Dec, 2015 | Pubmed ID: 26194427
Reply to "Considerations regarding the micromagnetic resonance relaxometry technique for rapid label-free malaria diagnosis".
Nature medicine Dec, 2015 | Pubmed ID: 26646491
Ultra-fast, label-free isolation of circulating tumor cells from blood using spiral microfluidics.
Nature protocols Jan, 2016 | Pubmed ID: 26678083
Broad spectrum immunomodulation using biomimetic blood cell margination for sepsis therapy.
Lab on a chip Feb, 2016 | Pubmed ID: 26767950
Study of individual erythrocyte deformability susceptibility to INFeD and ethanol using a microfluidic chip.
Scientific reports Mar, 2016 | Pubmed ID: 26964754
Multiplexed Affinity-Based Separation of Proteins and Cells Using Inertial Microfluidics.
Scientific reports , 2016 | Pubmed ID: 27026280
Gene disruption of dematin causes precipitous loss of erythrocyte membrane stability and severe hemolytic anemia.
Blood 07, 2016 | Pubmed ID: 27073223
Helical vortex formation in three-dimensional electrochemical systems with ion-selective membranes.
Physical review. E Mar, 2016 | Pubmed ID: 27078454
Enhanced Salt Removal by Unipolar Ion Conduction in Ion Concentration Polarization Desalination.
Scientific reports May, 2016 | Pubmed ID: 27158057
Differential Spleen Remodeling Associated with Different Levels of Parasite Virulence Controls Disease Outcome in Malaria Parasite Infections.
mSphere Jan-Feb, 2016 | Pubmed ID: 27303680
Liquid biopsy and therapeutic response: Circulating tumor cell cultures for evaluation of anticancer treatment.
Science advances 07, 2016 | Pubmed ID: 27453941
Purification of High Salinity Brine by Multi-Stage Ion Concentration Polarization Desalination.
Scientific reports Aug, 2016 | Pubmed ID: 27545955
Monitoring sepsis using electrical cell profiling.
Lab on a chip 11, 2016 | Pubmed ID: 27722555
Continuous micro-vortex-based nanoparticle manipulation via focused surface acoustic waves.
Lab on a chip 12, 2016 | Pubmed ID: 27883136
Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors.
Nature medicine Feb, 2017 | Pubmed ID: 28024083
Differentiation of Club Cells to Alveolar Epithelial Cells In Vitro.
Scientific reports Jan, 2017 | Pubmed ID: 28128362
Group 6 Layered Transition-Metal Dichalcogenides in Lab-on-a-Chip Devices: 1T-Phase WS for Microfluidics Non-Enzymatic Detection of Hydrogen Peroxide.
Analytical chemistry May, 2017 | Pubmed ID: 28394576
Patient-Derived Airway Secretion Dissociation Technique To Isolate and Concentrate Immune Cells Using Closed-Loop Inertial Microfluidics.
Analytical chemistry May, 2017 | Pubmed ID: 28402103
Integrated pretreatment and desalination by electrocoagulation (EC)-ion concentration polarization (ICP) hybrid.
Lab on a chip 06, 2017 | Pubmed ID: 28518195
Nanofluidic device for continuous multiparameter quality assurance of biologics.
Nature nanotechnology Aug, 2017 | Pubmed ID: 28530715
Microfluidic Cell Retention Device for Perfusion of Mammalian Suspension Culture.
Scientific reports Jul, 2017 | Pubmed ID: 28751635
Nanofluidic crystals: nanofluidics in a close-packed nanoparticle array.
Lab on a chip 09, 2017 | Pubmed ID: 28752878
Enabling electrical biomolecular detection in high ionic concentrations and enhancement of the detection limit thereof by coupling a nanofluidic crystal with reconfigurable ion concentration polarization.
Lab on a chip 11, 2017 | Pubmed ID: 28983543
Characterizing Deformability and Electrical Impedance of Cancer Cells in a Microfluidic Device.
Analytical chemistry Jan, 2018 | Pubmed ID: 29172457
Expansion of patient-derived circulating tumor cells from liquid biopsies using a CTC microfluidic culture device.
Nature protocols Jan, 2018 | Pubmed ID: 29215634
Force fields of charged particles in micro-nanofluidic preconcentration systems.
AIP advances Dec, 2017 | Pubmed ID: 29308297
Thrombospondin-1 protects against pathogen-induced lung injury by limiting extracellular matrix proteolysis.
JCI insight Feb, 2018 | Pubmed ID: 29415890
Microfluidic label-free selection of mesenchymal stem cell subpopulation during culture expansion extends the chondrogenic potential in vitro.
Lab on a chip 03, 2018 | Pubmed ID: 29459915
Characterization and application of size-sorted zonal chondrocytes for articular cartilage regeneration.
Biomaterials May, 2018 | Pubmed ID: 29518707
Negative Selection by Spiral Inertial Microfluidics Improves Viral Recovery and Sequencing from Blood.
Analytical chemistry Apr, 2018 | Pubmed ID: 29536737
Self-Aligned Acoustofluidic Particle Focusing and Patterning in Microfluidic Channels from Channel-Based Acoustic Waveguides.
Physical review letters Feb, 2018 | Pubmed ID: 29542954
Deciphering ion concentration polarization-based electrokinetic molecular concentration at the micro-nanofluidic interface: theoretical limits and scaling laws.
Nanoscale May, 2018 | Pubmed ID: 29790562
1Research Laboratory of Electronics, Massachusetts Institute of Technology,
2Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology,
3Department of Medicine, University of Pittsburgh,
4Department of Biological Engineering, Massachusetts Institute of Technology,
5Vascular Medicine Institute, University of Pittsburgh
SOBRE A JoVE
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