Medicine
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Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer.
Oncotarget Jul, 2016 | Pubmed ID: 27385211
Lipopolysaccharide-induced neutrophil gene expression under in vivo or in vitro conditions.
Chest Mar, 2002 | Pubmed ID: 11893694
Effects of catecholamines on kinase activation in lung neutrophils after hemorrhage or endotoxemia.
Journal of leukocyte biology Sep, 2002 | Pubmed ID: 12223526
Involvement of phosphatidylinositol 3-kinase gamma in neutrophil apoptosis.
Cellular signalling Feb, 2003 | Pubmed ID: 12464394
Evidence for extracellular superoxide dismutase as a mediator of hemorrhage-induced lung injury.
American journal of physiology. Lung cellular and molecular physiology Apr, 2003 | Pubmed ID: 12618426
Activation of gene expression in human neutrophils by high mobility group box 1 protein.
American journal of physiology. Cell physiology Apr, 2003 | Pubmed ID: 12620891
Early alterations in neutrophil activation are associated with outcome in acute lung injury.
American journal of respiratory and critical care medicine Jun, 2003 | Pubmed ID: 12626346
Urokinase-type plasminogen activator potentiates lipopolysaccharide-induced neutrophil activation.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2003 | Pubmed ID: 12759445
Modulation of bone marrow-derived neutrophil signaling by H2O2: disparate effects on kinases, NF-kappaB, and cytokine expression.
American journal of physiology. Cell physiology Mar, 2004 | Pubmed ID: 14656721
Hemorrhage-induced acute lung injury is TLR-4 dependent.
American journal of physiology. Regulatory, integrative and comparative physiology Sep, 2004 | Pubmed ID: 15072965
Genetic polymorphisms and sepsis.
Shock (Augusta, Ga.) Oct, 2005 | Pubmed ID: 16205313
Variant IRAK-1 haplotype is associated with increased nuclear factor-kappaB activation and worse outcomes in sepsis.
American journal of respiratory and critical care medicine Jun, 2006 | Pubmed ID: 16528020
HMGB1 and LPS induce distinct patterns of gene expression and activation in neutrophils from patients with sepsis-induced acute lung injury.
Intensive care medicine Oct, 2007 | Pubmed ID: 17581740
Association between urokinase haplotypes and outcome from infection-associated acute lung injury.
Intensive care medicine Feb, 2008 | Pubmed ID: 17994220
Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality.
American journal of respiratory and critical care medicine Jan, 2009 | Pubmed ID: 18948423
Gene array and fluorescence in situ hybridization biomarkers of activity of saracatinib (AZD0530), a Src inhibitor, in a preclinical model of colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research Aug, 2010 | Pubmed ID: 20682712
Identification of predictive markers of response to the MEK1/2 inhibitor selumetinib (AZD6244) in K-ras-mutated colorectal cancer.
Molecular cancer therapeutics Dec, 2010 | Pubmed ID: 20923857
Association between IL-32 genotypes and outcome in infection-associated acute lung injury.
Critical care (London, England) , 2011 | Pubmed ID: 21649914
Preclinical activity of the rational combination of selumetinib (AZD6244) in combination with vorinostat in KRAS-mutant colorectal cancer models.
Clinical cancer research : an official journal of the American Association for Cancer Research Feb, 2012 | Pubmed ID: 22173548
Similarity-based multimarker association tests for continuous traits.
Annals of human genetics May, 2012 | Pubmed ID: 22497480
Patient-derived tumour xenografts as models for oncology drug development.
Nature reviews. Clinical oncology Jun, 2012 | Pubmed ID: 22508028
ALDH+ tumor-initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ-secretase inhibitor and irinotecan in colorectal cancer.
Molecular oncology Jun, 2012 | Pubmed ID: 22521243
Common PIK3CA mutants and a novel 3' UTR mutation are associated with increased sensitivity to saracatinib.
Clinical cancer research : an official journal of the American Association for Cancer Research May, 2012 | Pubmed ID: 22553375
Phase I pharmacokinetic and pharmacodynamic study of cetuximab, irinotecan and sorafenib in advanced colorectal cancer.
Investigational new drugs Apr, 2013 | Pubmed ID: 22615057
Stromal cell-derived factor 1α mediates resistance to mTOR-directed therapy in pancreatic cancer.
Neoplasia (New York, N.Y.) Aug, 2012 | Pubmed ID: 22952422
Biomarker-driven trial in metastatic pancreas cancer: feasibility in a multicenter study of saracatinib, an oral Src inhibitor, in previously treated pancreatic cancer.
Cancer medicine Oct, 2012 | Pubmed ID: 23342270
Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models.
Frontiers in pharmacology , 2013 | Pubmed ID: 23543898
A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins.
Molecular oncology Aug, 2013 | Pubmed ID: 23607916
Rational combination of a MEK inhibitor, selumetinib, and the Wnt/calcium pathway modulator, cyclosporin A, in preclinical models of colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research Aug, 2013 | Pubmed ID: 23757356
hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression.
Biology open Jul, 2013 | Pubmed ID: 23862015
A phase II study of the gamma secretase inhibitor RO4929097 in patients with previously treated metastatic pancreatic adenocarcinoma.
Investigational new drugs Aug, 2014 | Pubmed ID: 24668033
Potent antitumor activity of cabozantinib, a c-MET and VEGFR2 inhibitor, in a colorectal cancer patient-derived tumor explant model.
International journal of cancer Apr, 2015 | Pubmed ID: 25242168
An improved high yield total synthesis and cytotoxicity study of the marine alkaloid neoamphimedine: an ATP-competitive inhibitor of topoisomerase IIα and potent anticancer agent.
Marine drugs Sep, 2014 | Pubmed ID: 25244109
Dual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancer.
PloS one , 2014 | Pubmed ID: 25401499
ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/β-Catenin, Notch and PI3K/Akt Signaling Pathways.
PloS one , 2015 | Pubmed ID: 25950950
Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models.
Frontiers in pharmacology , 2015 | Pubmed ID: 26136684
A NOTCH1 gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer.
International journal of cancer Jan, 2016 | Pubmed ID: 26152787
Targeting the WNT Signaling Pathway in Cancer Therapeutics.
The oncologist Oct, 2015 | Pubmed ID: 26306903
Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts.
Oncotarget Oct, 2015 | Pubmed ID: 26439693
Aldehyde Dehydrogenase 1B1 as a Modulator of Pancreatic Adenocarcinoma.
Pancreas Jan, 2016 | Pubmed ID: 26566217
The novel tankyrase inhibitor (AZ1366) enhances irinotecan activity in tumors that exhibit elevated tankyrase and irinotecan resistance.
Oncotarget May, 2016 | Pubmed ID: 27070088
Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2.
Journal of the National Cancer Institute Jan, 2017 | Pubmed ID: 27634934
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