Karen M. Vasquez

Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells.

Human XPA and RPA DNA repair proteins participate in specific recognition of triplex-induced helical distortions.

Triplex-forming oligonucleotides: principles and applications.

Site-directed recombination via bifunctional PNA-DNA conjugates.

Critical DNA damage recognition functions of XPC-hHR23B and XPA-RPA in nucleotide excision repair.

Mutation frequencies in murine keratinocytes as a function of carcinogenic status.

Naturally occurring H-DNA-forming sequences are mutagenic in mammalian cells.

Interplay between human high mobility group protein 1 and replication protein A on psoralen-cross-linked DNA.

Mismatch repair participates in error-free processing of DNA interstrand crosslinks in human cells.

Human XPC-hHR23B interacts with XPA-RPA in the recognition of triplex-directed psoralen DNA interstrand crosslinks.

Repair of genome destabilizing lesions.

Z-DNA-forming sequences generate large-scale deletions in mammalian cells.

Non-B DNA structure-induced genetic instability.

Targeting oncogenes to improve breast cancer chemotherapy.

A web-based search engine for triplex-forming oligonucleotide target sequences.

High-affinity triplex-forming oligonucleotide target sequences in mammalian genomes.

Therapeutic effect of rapamycin on gallbladder cancer in a transgenic mouse model.

Z-DNA, an active element in the genome.

A triplex-forming sequence from the human c-MYC promoter interferes with DNA transcription.

DNA triple helices: biological consequences and therapeutic potential.

Inhibitory effect of a short Z-DNA forming sequence on transcription elongation by T7 RNA polymerase.

Targeted generation of DNA strand breaks using pyrene-conjugated triplex-forming oligonucleotides.

Processing of triplex-directed psoralen DNA interstrand crosslinks by recombination mechanisms.

High mobility group protein B1 enhances DNA repair and chromatin modification after DNA damage.

Human MLH1 protein participates in genomic damage checkpoint signaling in response to DNA interstrand crosslinks, while MSH2 functions in DNA repair.

Efficient processing of TFO-directed psoralen DNA interstrand crosslinks by the UvrABC nuclease.

DNA structure-induced genomic instability in vivo.

Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells.

Models for chromosomal replication-independent non-B DNA structure-induced genetic instability.

Methods to determine DNA structural alterations and genetic instability.

Intrinsic genomic instability from naturally occurring DNA structures: An introduction to the special issue.

HMGB1: the jack-of-all-trades protein is a master DNA repair mechanic.

Human HMGB1 directly facilitates interactions between nucleotide excision repair proteins on triplex-directed psoralen interstrand crosslinks.

Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks.

Cruciform-forming inverted repeats appear to have mediated many of the microinversions that distinguish the human and chimpanzee genomes.

Targeted gene conversion induced by triplex-directed psoralen interstrand crosslinks in mammalian cells.

Non-B DNA structure-induced genetic instability and evolution.

2,6-Dithiopurine blocks toxicity and mutagenesis in human skin cells exposed to sulfur mustard analogues, 2-chloroethyl ethyl sulfide and 2-chloroethyl methyl sulfide.

Targeting and processing of site-specific DNA interstrand crosslinks.

Pathways for double-strand break repair in genetically unstable Z-DNA-forming sequences.

DNA interstrand crosslinks: repair, cell signaling, and therapeutic implications.

Human DHX9 helicase unwinds triple-helical DNA structures.

Triplex technology in studies of DNA damage, DNA repair, and mutagenesis.

On the sequence-directed nature of human gene mutation: the role of genomic architecture and the local DNA sequence environment in mediating gene mutations underlying human inherited disease.

2,6-Dithiopurine, a nucleophilic scavenger, protects against mutagenesis in mouse skin treated in vivo with 2-(chloroethyl) ethyl sulfide, a mustard gas analog.

The yin and yang of repair mechanisms in DNA structure-induced genetic instability.

Direct and inverted repeats elicit genetic instability by both exploiting and eluding DNA double-strand break repair systems in mycobacteria.

FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions.

Triplex-forming oligonucleotides targeting c-MYC potentiate the anti-tumor activity of gemcitabine in a mouse model of human cancer.

DNA structure matters.

Methods to detect replication-dependent and replication-independent DNA structure-induced genetic instability.

DHX9 helicase is involved in preventing genomic instability induced by alternatively structured DNA in human cells.

Guanine holes are prominent targets for mutation in cancer and inherited disease.

Mechanisms of base substitution mutagenesis in cancer genomes.

Impact of alternative DNA structures on DNA damage, DNA repair, and genetic instability.

Short Inverted Repeats Are Hotspots for Genetic Instability: Relevance to Cancer Genomes.

Local DNA dynamics shape mutational patterns of mononucleotide repeats in human genomes.

The somatic autosomal mutation matrix in cancer genomes.

Erratum to: The somatic autosomal mutation matrix in cancer genomes.

Long non-coding RNA: A new paradigm for lung cancer.

HMGB1 interacts with XPA to facilitate the processing of DNA interstrand crosslinks in human cells.

New Perspectives on DNA and RNA Triplexes As Effectors of Biological Activity.

Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences.

Detection of cis- and trans-acting Factors in DNA Structure-Induced Genetic Instability Using In silico and Cellular Approaches.