Naoto Hirano

Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application.

The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells.

Autoantibodies frequently detected in patients with aplastic anemia.

Presence of anti-kinectin and anti-PMS1 antibodies in Japanese aplastic anaemia patients.

The chemical structure of the Hawaiian mantle plume.

Engagement of CD83 ligand induces prolonged expansion of CD8+ T cells and preferential enrichment for antigen specificity.

Efficient presentation of naturally processed HLA class I peptides by artificial antigen-presenting cells for the generation of effective antitumor responses.

Identification of an immunogenic CD8+ T-cell epitope derived from gamma-globin, a putative tumor-associated antigen for juvenile myelomonocytic leukemia.

Volcanism in response to plate flexure.

Long-lived antitumor CD8+ lymphocytes for adoptive therapy generated using an artificial antigen-presenting cell.

Clinical impact of HLA-DR15, a minor population of paroxysmal nocturnal haemoglobinuria-type cells, and an aplastic anaemia-associated autoantibody in children with acquired aplastic anaemia.

Dissociation of its opposing immunologic effects is critical for the optimization of antitumor CD8+ T-cell responses induced by interleukin 21.

Juvenile myelomonocytic leukemia: epidemiology, etiopathogenesis, diagnosis, and management considerations.

A panel of human cell-based artificial APC enables the expansion of long-lived antigen-specific CD4+ T cells restricted by prevalent HLA-DR alleles.

Establishment of antitumor memory in humans using in vitro-educated CD8+ T cells.

The Third Consensus Conference on the treatment of aplastic anemia.

Induction of HLA-DP4-restricted anti-survivin Th1 and Th2 responses using an artificial antigen-presenting cell.

[The cutting edge of antitumor adoptive cell therapy].

IL-21 Can Supplement Suboptimal Lck-Independent MAPK Activation in a STAT-3-Dependent Manner in Human CD8+ T Cells.

Ex vivo expansion of human CD8 T cells using autologous CD4 T cell help.

Human cell-based artificial antigen-presenting cells for cancer immunotherapy.

Specific roles of each TCR hemichain in generating functional chain-centric TCR.

Optimization of T-cell Reactivity by Exploiting TCR Chain Centricity for the Purpose of Safe and Effective Antitumor TCR Gene Therapy.

Adoptive T Cell Therapy Targeting CD1 and MR1.

CDR3β sequence motifs regulate autoreactivity of human invariant NKT cell receptors.

CD4(+) and CD8(+) TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells.

Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors.

BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models.