Department of Microbiology,
Immunology and Molecular Genetics,
Department of Microbiology, Immunology and Molecular Genetics
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Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification.
The Journal of experimental medicine Sep, 2002 | Pubmed ID: 12208878
Ongoing in vivo immunoglobulin class switch DNA recombination in chronic lymphocytic leukemia B cells.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2002 | Pubmed ID: 12444172
Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements.
The Journal of biological chemistry Jun, 2003 | Pubmed ID: 12672812
AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in somatic hypermutation.
Immunity Jun, 2003 | Pubmed ID: 12818155
Immunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair.
Journal of clinical immunology Jul, 2003 | Pubmed ID: 12959216
Class switching and Myc translocation: how does DNA break?
Nature immunology Nov, 2004 | Pubmed ID: 15496946
DNA lesions and repair in immunoglobulin class switch recombination and somatic hypermutation.
Annals of the New York Academy of Sciences Jun, 2005 | Pubmed ID: 16014529
The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation.
The EMBO journal Nov, 2005 | Pubmed ID: 16222339
Biased dA/dT somatic hypermutation as regulated by the heavy chain intronic iEmu enhancer and 3'Ealpha enhancers in human lymphoblastoid B cells.
Molecular immunology Apr, 2006 | Pubmed ID: 16412510
A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation.
Journal of immunology (Baltimore, Md. : 1950) May, 2006 | Pubmed ID: 16622010
DNA repair in antibody somatic hypermutation.
Trends in immunology Jul, 2006 | Pubmed ID: 16737852
DNA replication to aid somatic hypermutation.
Advances in experimental medicine and biology , 2007 | Pubmed ID: 17338180
Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination.
Critical reviews in immunology , 2007 | Pubmed ID: 18197815
A role for DRAK2 in the germinal center reaction and the antibody response.
Autoimmunity Aug, 2008 | Pubmed ID: 18568639
AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID.
Molecular immunology Nov, 2008 | Pubmed ID: 18760480
Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.
Autoimmunity Feb, 2009 | Pubmed ID: 19156553
HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation.
Nature immunology May, 2009 | Pubmed ID: 19363484
Toll-like receptors and B-cell receptors synergize to induce immunoglobulin class-switch DNA recombination: relevance to microbial antibody responses.
Critical reviews in immunology , 2010 | Pubmed ID: 20370617
14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination.
Nature structural & molecular biology Sep, 2010 | Pubmed ID: 20729863
Specific cross-reaction of anti-dsDNA antibody with platelet integrin GPIIIa49-66.
Autoimmunity Dec, 2010 | Pubmed ID: 20828249
Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutation.
The Journal of biological chemistry Nov, 2010 | Pubmed ID: 20855884
Three fatal cases of pandemic 2009 influenza A virus infection in Shenzhen are associated with cytokine storm.
Respiratory physiology & neurobiology Jan, 2011 | Pubmed ID: 21075220
Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regions.
Molecular immunology Jan, 2011 | Pubmed ID: 21111482
AID dysregulation in lupus-prone MRL/Fas(lpr/lpr) mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: modulation by HoxC4.
Autoimmunity Dec, 2011 | Pubmed ID: 21585311
Viral kinetics of enterovirus 71 in human abdomyosarcoma cells.
World journal of gastroenterology Sep, 2011 | Pubmed ID: 22039330
BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway.
Nature communications Apr, 2012 | Pubmed ID: 22473011
B cell TLRs and induction of immunoglobulin class-switch DNA recombination.
Frontiers in bioscience (Landmark edition) Jun, 2012 | Pubmed ID: 22652800
Immunoglobulin class-switch DNA recombination: induction, targeting and beyond.
Nature reviews. Immunology Jun, 2012 | Pubmed ID: 22728528
Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination.
Cell reports Nov, 2012 | Pubmed ID: 23140944
Regulation of Aicda expression and AID activity.
Autoimmunity Mar, 2013 | Pubmed ID: 23181381
Epigenetics of the antibody response.
Trends in immunology Sep, 2013 | Pubmed ID: 23643790
Combinatorial H3K9acS10ph histone modification in IgH locus S regions targets 14-3-3 adaptors and AID to specify antibody class-switch DNA recombination.
Cell reports Nov, 2013 | Pubmed ID: 24209747
MicroRNAs in lupus.
Autoimmunity Jun, 2014 | Pubmed ID: 24826805
Epigenetics in lupus.
Autoimmunity Jun, 2014 | Pubmed ID: 24826881
Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2014 | Pubmed ID: 25392531
Genome-Wide Analysis Reveals Selective Modulation of microRNAs and mRNAs by Histone Deacetylase Inhibitor in B Cells Induced to Undergo Class-Switch DNA Recombination and Plasma Cell Differentiation.
Frontiers in immunology , 2015 | Pubmed ID: 26697020
Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response.
Frontiers in immunology , 2015 | Pubmed ID: 26697022
Editorial: Epigenetics of B Cells and Antibody Responses.
Frontiers in immunology , 2015 | Pubmed ID: 26793194
Small Molecule Inhibition of Rab7 Impairs B Cell Class Switching and Plasma Cell Survival To Dampen the Autoantibody Response in Murine Lupus.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2016 | Pubmed ID: 27742832
Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination.
Nature communications Feb, 2017 | Pubmed ID: 28176781
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