Department of Development and Regeneration
Joris Vriens is Full Professor at the Department Development & Regeneration at the University of Leuven in Belgium. He received his PhD in Biomedical Sciences at the University of Leuven investigating the different activation mechanism of the TRPV4 ion channel. As a post doctoral researcher he went abroad to the lab of Prof Clapham at the Harvard Medical School, Boston, US to assess the Total Internal Reflection Fluorescence Microscopy to study the trafficking of ion channels to the plasma membrane. After his post doc period he returned to the lab of ion channel research where he initiated new research projects on TRPM3. Together with prof Voets he characterized TRPM3 as an important nociceptor in the peripheral nerve system and an interesting target for the development of novel analgesics for the treatment of different types of pain. In 2011, Vriens became the head of the lab of endometrium, endometriosis and reproductive medicine (LEERM) at the Leuven University. His research group continues to pioneer and investigate the role of ion channels in the female reproductive system with a particular focus on endometrial receptivity and assess the role of ion channels in placental function and development. The lab of Vriens is part of the Center of Ion Channel Research headed by Prof Voets.
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives.
The Journal of biological chemistry Apr, 2002 | Pubmed ID: 11827975
Molecular determinants of permeation through the cation channel TRPV4.
The Journal of biological chemistry Sep, 2002 | Pubmed ID: 12093812
Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells.
The Journal of biological chemistry Dec, 2002 | Pubmed ID: 12354759
The TRPV4 channel: structure-function relationship and promiscuous gating behaviour.
Pflugers Archiv : European journal of physiology Jun, 2003 | Pubmed ID: 12715179
Modulation of TRPV4 gating by intra- and extracellular Ca2+.
Cell calcium May-Jun, 2003 | Pubmed ID: 12765694
Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels.
Nature Jul, 2003 | Pubmed ID: 12879072
TRPV4 calcium entry channel: a paradigm for gating diversity.
American journal of physiology. Cell physiology Feb, 2004 | Pubmed ID: 14707014
TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells.
Cell calcium Jul, 2004 | Pubmed ID: 15126053
Invertebrate TRP proteins as functional models for mammalian channels.
Pflugers Archiv : European journal of physiology Dec, 2004 | Pubmed ID: 15480752
TRPV1 is involved in stretch-evoked contractile changes in the rat autonomous bladder model: a study with piperine, a new TRPV1 agonist.
Neurourology and urodynamics , 2007 | Pubmed ID: 17266134
Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4.
The Journal of biological chemistry Apr, 2007 | Pubmed ID: 17341586
Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding.
The Journal of clinical investigation Nov, 2007 | Pubmed ID: 17948126
Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons.
PloS one May, 2008 | Pubmed ID: 18461159
Role of cytochrome P450-dependent transient receptor potential V4 activation in flow-induced vasodilatation.
Cardiovascular research Dec, 2008 | Pubmed ID: 18682435
TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts.
Cell metabolism Sep, 2008 | Pubmed ID: 18762026
Mutations in the gene encoding the calcium-permeable ion channel TRPV4 produce spondylometaphyseal dysplasia, Kozlowski type and metatropic dysplasia.
American journal of human genetics Mar, 2009 | Pubmed ID: 19232556
Pharmacology of vanilloid transient receptor potential cation channels.
Molecular pharmacology Jun, 2009 | Pubmed ID: 19297520
Herbal compounds and toxins modulating TRP channels.
Current neuropharmacology Mar, 2008 | Pubmed ID: 19305789
TRPM1 forms ion channels associated with melanin content in melanocytes.
Science signaling May, 2009 | Pubmed ID: 19436059
Functional characterization of transient receptor potential channels in mouse urothelial cells.
American journal of physiology. Renal physiology Mar, 2010 | Pubmed ID: 20015940
Dominant TRPV4 mutations in nonlethal and lethal metatropic dysplasia.
American journal of medical genetics. Part A May, 2010 | Pubmed ID: 20425821
Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2010 | Pubmed ID: 20956320
TRPM3 is a nociceptor channel involved in the detection of noxious heat.
Neuron May, 2011 | Pubmed ID: 21555074
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system.
Brain : a journal of neurology Feb, 2012 | Pubmed ID: 22036959
Cholesterol loss during glutamate-mediated excitotoxicity.
The EMBO journal Apr, 2012 | Pubmed ID: 22343944
Vascular hypoxic preconditioning relies on TRPV4-dependent calcium influx and proper intercellular gap junctions communication.
Arteriosclerosis, thrombosis, and vascular biology Sep, 2012 | Pubmed ID: 22814746
Opening of an alternative ion permeation pathway in a nociceptor TRP channel.
Nature chemical biology Mar, 2014 | Pubmed ID: 24390427
Peripheral thermosensation in mammals.
Nature reviews. Neuroscience Sep, 2014 | Pubmed ID: 25053448
TRPV4 participates in the establishment of trailing adhesions and directional persistence of migrating cells.
Pflugers Archiv : European journal of physiology Oct, 2015 | Pubmed ID: 25559845
Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2015 | Pubmed ID: 25733887
Functional expression of transient receptor potential channels in human endometrial stromal cells during the luteal phase of the menstrual cycle.
Human reproduction (Oxford, England) Jun, 2015 | Pubmed ID: 25820697
Regulation of the transient receptor potential channel TRPM3 by phosphoinositides.
The Journal of general physiology Jul, 2015 | Pubmed ID: 26123194
Signature and Pathophysiology of Non-canonical Pores in Voltage-Dependent Cation Channels.
Reviews of physiology, biochemistry and pharmacology , 2016 | Pubmed ID: 26791748
VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8.
Nature communications Feb, 2016 | Pubmed ID: 26843440
Urine of Preterm Neonates as a Novel Source of Kidney Progenitor Cells.
Journal of the American Society of Nephrology : JASN Sep, 2016 | Pubmed ID: 26940093
Laparoscopic Surgery: A New Technique to Induce Endometriosis in a Mouse Model.
Reproductive sciences (Thousand Oaks, Calif.) Oct, 2016 | Pubmed ID: 26994066
TRPM3 in temperature sensing and beyond.
Temperature (Austin, Tex.) Apr-Jun, 2015 | Pubmed ID: 27227024
TRPV4 is associated with central rather than nephrogenic osmoregulation.
Pflugers Archiv : European journal of physiology Sep, 2016 | Pubmed ID: 27364478
Definition of two agonist types at the mammalian cold-activated channel TRPM8.
eLife Jul, 2016 | Pubmed ID: 27449282
Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy.
Cancer cell Dec, 2016 | Pubmed ID: 27866851
The functional expression of transient receptor potential channels in the mouse endometrium.
Human reproduction (Oxford, England) Jan, 2017 | Pubmed ID: 28077439
A cellular pathway controlling functional plasma membrane incorporation of the cold sensor TRPM8.
Temperature (Austin, Tex.) , 2016 | Pubmed ID: 28090554
TRP channel pores and local calcium signals.
Cell calcium 09, 2017 | Pubmed ID: 28807146
Of Mice and Women: A Laparoscopic Mouse Model for Endometriosis.
Journal of minimally invasive gynecology May - Jun, 2018 | Pubmed ID: 29032250
Sensing the heat with TRPM3.
Pflugers Archiv : European journal of physiology 05, 2018 | Pubmed ID: 29305649
Optimization of Endometrial Decidualization in the Menstruating Mouse Model for Preclinical Endometriosis Research.
Reproductive sciences (Thousand Oaks, Calif.) 11, 2018 | Pubmed ID: 29455621
Mutations in the voltage-sensing domain affect the alternative ion permeation pathway in the TRPM3 channel.
The Journal of physiology 06, 2018 | Pubmed ID: 29604058
Functional Expression of TRP Ion Channels in Endometrial Stromal Cells of Endometriosis Patients.
International journal of molecular sciences Aug, 2018 | Pubmed ID: 30134548
Functional expression of the mechanosensitive PIEZO1 channel in primary endometrial epithelial cells and endometrial organoids.
Scientific reports 02, 2019 | Pubmed ID: 30741991
Establishing life is a calcium-dependent TRiP: Transient receptor potential channels in reproduction.
Biochimica et biophysica acta. Molecular cell research 11, 2018 | Pubmed ID: 30798946
High-resolution contrast-enhanced microCT reveals the true three-dimensional morphology of the murine placenta.
Proceedings of the National Academy of Sciences of the United States of America 07, 2019 | Pubmed ID: 31249139
Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening.
Nature cell biology 08, 2019 | Pubmed ID: 31371824
Heat sensing involves a TRiPlet of ion channels.
British journal of pharmacology 10, 2019 | Pubmed ID: 31372975
Targeting TRP Channels - Valuable Alternatives to Combat Pain, Lower Urinary Tract Disorders, and Type 2 Diabetes?
Trends in pharmacological sciences 09, 2019 | Pubmed ID: 31395287
Functional expression and pharmacological modulation of TRPM3 in human sensory neurons.
British journal of pharmacology Jun, 2020 | Pubmed ID: 31985045
The Sensory Coding of Warm Perception.
Neuron 06, 2020 | Pubmed ID: 32208171
Mimicking Sampson's Retrograde Menstrual Theory in Rats: A New Rat Model for Ongoing Endometriosis-Associated Pain.
International journal of molecular sciences Mar, 2020 | Pubmed ID: 32230898
Double-label immunohistochemistry to assess labyrinth structure of the mouse placenta with stereology.
Placenta 05, 2020 | Pubmed ID: 32421534
Gain of channel function and modified gating properties in TRPM3 mutants causing intellectual disability and epilepsy.
eLife May, 2020 | Pubmed ID: 32427099
Pharmacological properties of TRPM3 isoforms are determined by the length of the pore loop.
British journal of pharmacology Aug, 2020 | Pubmed ID: 32780479
Reply to: Heat detection by the TRPM2 ion channel.
Nature Aug, 2020 | Pubmed ID: 32788731
Upregulation of TRPM3 in nociceptors innervating inflamed tissue.
eLife 09, 2020 | Pubmed ID: 32880575
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