Biomedical Sciences & Iowa Center for Advanced Neurotoxicology
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Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2002 | Pubmed ID: 11880503
Oxidative stress and mitochondrial-mediated apoptosis in dopaminergic cells exposed to methylcyclopentadienyl manganese tricarbonyl.
The Journal of pharmacology and experimental therapeutics Jul, 2002 | Pubmed ID: 12065696
5-hydroxytryptamine 1A receptor activation protects against N-methyl-D-aspartate-induced apoptotic cell death in striatal and mesencephalic cultures.
The Journal of pharmacology and experimental therapeutics Mar, 2003 | Pubmed ID: 12604665
Antimyoclonic and neuroprotective effects of lamotrigine in an animal model of cardiac arrest.
Restorative neurology and neuroscience , 1999 | Pubmed ID: 12671243
Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration.
The European journal of neuroscience Sep, 2003 | Pubmed ID: 14511319
Role of proteolytic activation of protein kinase Cdelta in oxidative stress-induced apoptosis.
Antioxidants & redox signaling Oct, 2003 | Pubmed ID: 14580317
Suppression of caspase-3-dependent proteolytic activation of protein kinase C delta by small interfering RNA prevents MPP+-induced dopaminergic degeneration.
Molecular and cellular neurosciences Mar, 2004 | Pubmed ID: 15033169
Dieldrin promotes proteolytic cleavage of poly(ADP-ribose) polymerase and apoptosis in dopaminergic cells: protective effect of mitochondrial anti-apoptotic protein Bcl-2.
Neurotoxicology Jun, 2004 | Pubmed ID: 15183012
Activation of protein kinase C delta by proteolytic cleavage contributes to manganese-induced apoptosis in dopaminergic cells: protective role of Bcl-2.
Biochemical pharmacology Jan, 2005 | Pubmed ID: 15588722
Protein kinase Cdelta is a key downstream mediator of manganese-induced apoptosis in dopaminergic neuronal cells.
The Journal of pharmacology and experimental therapeutics Apr, 2005 | Pubmed ID: 15608081
Blood lipid and oxidative stress responses to soy protein with isoflavones and phytic acid in postmenopausal women.
The American journal of clinical nutrition Mar, 2005 | Pubmed ID: 15755827
Tyrosine phosphorylation regulates the proteolytic activation of protein kinase Cdelta in dopaminergic neuronal cells.
The Journal of biological chemistry Aug, 2005 | Pubmed ID: 15961393
Wild-type alpha-synuclein interacts with pro-apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death.
Brain research. Molecular brain research Sep, 2005 | Pubmed ID: 15978696
Dieldrin induces ubiquitin-proteasome dysfunction in alpha-synuclein overexpressing dopaminergic neuronal cells and enhances susceptibility to apoptotic cell death.
The Journal of pharmacology and experimental therapeutics Oct, 2005 | Pubmed ID: 15987830
Dieldrin-induced neurotoxicity: relevance to Parkinson's disease pathogenesis.
Neurotoxicology Aug, 2005 | Pubmed ID: 16112328
Interaction of metals with prion protein: possible role of divalent cations in the pathogenesis of prion diseases.
Neurotoxicology Sep, 2006 | Pubmed ID: 16860868
Proteasome inhibitor MG-132 induces dopaminergic degeneration in cell culture and animal models.
Neurotoxicology Sep, 2006 | Pubmed ID: 16870259
A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models.
Free radical biology & medicine Nov, 2006 | Pubmed ID: 17045926
Microarray analysis of oxidative stress regulated genes in mesencephalic dopaminergic neuronal cells: relevance to oxidative damage in Parkinson's disease.
Neurochemistry international May, 2007 | Pubmed ID: 17397968
Normal cellular prion protein protects against manganese-induced oxidative stress and apoptotic cell death.
Toxicological sciences : an official journal of the Society of Toxicology Aug, 2007 | Pubmed ID: 17483122
Environmental neurotoxic chemicals-induced ubiquitin proteasome system dysfunction in the pathogenesis and progression of Parkinson's disease.
Pharmacology & therapeutics Jun, 2007 | Pubmed ID: 17521740
Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease.
The Journal of pharmacology and experimental therapeutics Sep, 2007 | Pubmed ID: 17565007
Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells.
Neurotoxicology Sep, 2007 | Pubmed ID: 17904225
Neuroprotective effect of the natural iron chelator, phytic acid in a cell culture model of Parkinson's disease.
Toxicology Mar, 2008 | Pubmed ID: 18255213
Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCdelta proteolytic activation and mitochondrial translocation.
Journal of cellular and molecular medicine Dec, 2008 | Pubmed ID: 18298651
Opposing roles of prion protein in oxidative stress- and ER stress-induced apoptotic signaling.
Free radical biology & medicine Dec, 2008 | Pubmed ID: 18835352
Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease.
Molecular brain , 2008 | Pubmed ID: 18945348
Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys-48 and -63.
Journal of cellular and molecular medicine Aug, 2009 | Pubmed ID: 19432818
Vanadium induces dopaminergic neurotoxicity via protein kinase Cdelta dependent oxidative signaling mechanisms: relevance to etiopathogenesis of Parkinson's disease.
Toxicology and applied pharmacology Oct, 2009 | Pubmed ID: 19646462
Curcumin enhances paraquat-induced apoptosis of N27 mesencephalic cells via the generation of reactive oxygen species.
Neurotoxicology Nov, 2009 | Pubmed ID: 19660496
Manganese upregulates cellular prion protein and contributes to altered stabilization and proteolysis: relevance to role of metals in pathogenesis of prion disease.
Toxicological sciences : an official journal of the Society of Toxicology Jun, 2010 | Pubmed ID: 20176619
A simple magnetic separation method for high-yield isolation of pure primary microglia.
Journal of neuroscience methods Jan, 2011 | Pubmed ID: 21074565
α-Synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2011 | Pubmed ID: 21307242
Phytic Acid Protects against 6-Hydroxydopamine-Induced Dopaminergic Neuron Apoptosis in Normal and Iron Excess Conditions in a Cell Culture Model.
Parkinson's disease Feb, 2011 | Pubmed ID: 21331377
Transcriptional regulation of pro-apoptotic protein kinase Cdelta: implications for oxidative stress-induced neuronal cell death.
The Journal of biological chemistry Jun, 2011 | Pubmed ID: 21467032
PKCδ inhibition enhances tyrosine hydroxylase phosphorylation in mice after methamphetamine treatment.
Neurochemistry international Aug, 2011 | Pubmed ID: 21672585
Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration.
Molecular neurodegeneration Jun, 2011 | Pubmed ID: 21696630
Environmental neurotoxic pesticide dieldrin activates a non receptor tyrosine kinase to promote PKCδ-mediated dopaminergic apoptosis in a dopaminergic neuronal cell model.
Neurotoxicology Oct, 2011 | Pubmed ID: 21801747
Measurement of proteasomal dysfunction in cell models of dopaminergic degeneration.
Methods in molecular biology (Clifton, N.J.) , 2011 | Pubmed ID: 21815074
Manganese nanoparticle activates mitochondrial dependent apoptotic signaling and autophagy in dopaminergic neuronal cells.
Toxicology and applied pharmacology Nov, 2011 | Pubmed ID: 21856324
Infectious prion protein alters manganese transport and neurotoxicity in a cell culture model of prion disease.
Neurotoxicology Oct, 2011 | Pubmed ID: 21871919
Neuroprotective effect of resveratrol against methamphetamine-induced dopaminergic apoptotic cell death in a cell culture model of neurotoxicity.
Current neuropharmacology Mar, 2011 | Pubmed ID: 21886561
Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ.
Behavioural brain research Jun, 2012 | Pubmed ID: 22512859
Proteolytic activation of proapoptotic kinase protein kinase Cδ by tumor necrosis factor α death receptor signaling in dopaminergic neurons during neuroinflammation.
Journal of neuroinflammation Apr, 2012 | Pubmed ID: 22540228
Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: lack of correlation with superoxide generation.
Journal of neurochemistry Sep, 2012 | Pubmed ID: 22708893
Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy Apr, 2012 | Pubmed ID: 22966490
Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease.
Journal of neuroinflammation Oct, 2012 | Pubmed ID: 23092448
Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R¹⁴⁴¹G) transgenic mouse.
Neuroscience letters Aug, 2013 | Pubmed ID: 23721786
The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease.
The Journal of biological chemistry Jul, 2013 | Pubmed ID: 23754278
Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes.
Biochimica et biophysica acta Aug, 2014 | Pubmed ID: 24060637
Vanadium exposure induces olfactory dysfunction in an animal model of metal neurotoxicity.
Neurotoxicology Jul, 2014 | Pubmed ID: 24362016
Role of proteolytic activation of protein kinase Cδ in the pathogenesis of prion disease.
Prion Jan-Feb, 2014 | Pubmed ID: 24576946
Protein kinase D1 (PKD1) phosphorylation promotes dopaminergic neuronal survival during 6-OHDA-induced oxidative stress.
PloS one , 2014 | Pubmed ID: 24806360
A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease.
Neuroscience letters Nov, 2014 | Pubmed ID: 25263790
Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease.
The Journal of biological chemistry Dec, 2014 | Pubmed ID: 25342743
α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson's disease.
Toxicological sciences : an official journal of the Society of Toxicology Feb, 2015 | Pubmed ID: 25416158
In vitro amplification of scrapie and chronic wasting disease PrP(res) using baculovirus-expressed recombinant PrP as substrate.
Prion , 2014 | Pubmed ID: 25495764
Nanoneuromedicines for degenerative, inflammatory, and infectious nervous system diseases.
Nanomedicine : nanotechnology, biology, and medicine Apr, 2015 | Pubmed ID: 25645958
Alterations in mitochondrial dynamics induced by tebufenpyrad and pyridaben in a dopaminergic neuronal cell culture model.
Neurotoxicology Mar, 2016 | Pubmed ID: 26141520
Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2015 | Pubmed ID: 26157004
Molecular cloning, epigenetic regulation, and functional characterization of Prkd1 gene promoter in dopaminergic cell culture models of Parkinson's disease.
Journal of neurochemistry Oct, 2015 | Pubmed ID: 26230914
Nano-enabled delivery of diverse payloads across complex biological barriers.
Journal of controlled release : official journal of the Controlled Release Society Dec, 2015 | Pubmed ID: 26315817
EGCG Protects against 6-OHDA-Induced Neurotoxicity in a Cell Culture Model.
Parkinson's disease , 2015 | Pubmed ID: 26770869
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy Jan, 2016 | Pubmed ID: 26799652
Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson's Disease.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology Jun, 2016 | Pubmed ID: 26838361
p73 gene in dopaminergic neurons is highly susceptible to manganese neurotoxicity.
Neurotoxicology Mar, 2017 | Pubmed ID: 27107493
Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease.
Neurobiology of disease Sep, 2016 | Pubmed ID: 27151770
Hepcidin Plays a Key Role in 6-OHDA Induced Iron Overload and Apoptotic Cell Death in a Cell Culture Model of Parkinson's Disease.
Parkinson's disease , 2016 | Pubmed ID: 27298749
Differential arousal regulation by prokineticin 2 signaling in the nocturnal mouse and the diurnal monkey.
Molecular brain Aug, 2016 | Pubmed ID: 27535380
Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration.
Nature communications Oct, 2016 | Pubmed ID: 27703142
Neuronal protection against oxidative insult by polyanhydride nanoparticle-based mitochondria-targeted antioxidant therapy.
Nanomedicine : nanotechnology, biology, and medicine Oct, 2016 | Pubmed ID: 27771430
Role of protein kinase C in metabolic regulation of the cardiac Na(+) channel.
Heart rhythm Mar, 2017 | Pubmed ID: 27989687
Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation.
Brain research bulletin Dec, 2016 | Pubmed ID: 27993598
Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice.
Antioxidants & redox signaling Apr, 2017 | Pubmed ID: 28375739
Molecular Mechanisms Underlying Protective Effects of Quercetin Against Mitochondrial Dysfunction and Progressive Dopaminergic Neurodegeneration in Cell Culture and MitoPark Transgenic Mouse Models of Parkinson's Disease.
Journal of neurochemistry Apr, 2017 | Pubmed ID: 28376279
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