Institute of New Drug Research,
Guangdong Provincial Key Laboratory of Pharmacodynamic,
Constituents of Traditional Chinese Medicine & New Drug Research,
College of Pharmacy,
Institute of New Drug Research, Guangdong Provincial Key Laboratory of Pharmacodynamic, Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy
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Synthesis and preliminary antitumor activity evaluation of a DHA and doxorubicin conjugate.
Bioorganic & medicinal chemistry letters Jun, 2006 | Pubmed ID: 16563756
Synthesis and antitumor activity evaluations of albumin-binding prodrugs of CC-1065 analog.
Bioorganic & medicinal chemistry Jul, 2008 | Pubmed ID: 18508273
Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke.
Bioorganic & medicinal chemistry Oct, 2008 | Pubmed ID: 18790647
Synthesis and evaluation of antibacterial activities of andrographolide analogues.
European journal of medicinal chemistry Jul, 2009 | Pubmed ID: 19152987
Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment.
Journal of translational medicine Jul, 2009 | Pubmed ID: 19607676
Preventive effects of Flos Perariae (Gehua) water extract and its active ingredient puerarin in rodent alcoholism models.
Chinese medicine Oct, 2010 | Pubmed ID: 20974012
Synthesis and biological evaluations of novel apocynin analogues.
European journal of medicinal chemistry Jul, 2011 | Pubmed ID: 21514981
Eriocaulon buergerianum extract protects PC12 cells and neurons in zebrafish against 6-hydroxydopamine-induced damage.
Chinese medicine Apr, 2011 | Pubmed ID: 21527031
Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through α7 nAChR.
Brain research Jul, 2011 | Pubmed ID: 21665194
Novel multi-functional nitrones for treatment of ischemic stroke.
Bioorganic & medicinal chemistry Jun, 2012 | Pubmed ID: 22579617
Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways.
Journal of agricultural and food chemistry Aug, 2012 | Pubmed ID: 22838648
Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs.
Biological & pharmaceutical bulletin , 2012 | Pubmed ID: 22863928
Unexpected neuronal protection of SU5416 against 1-Methyl-4-phenylpyridinium ion-induced toxicity via inhibiting neuronal nitric oxide synthase.
PloS one , 2012 | Pubmed ID: 23049997
The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS.
British journal of pharmacology Mar, 2013 | Pubmed ID: 23062100
Anti-Lung-Cancer Activity and Liposome-Based Delivery Systems of β-Elemene.
Evidence-based complementary and alternative medicine : eCAM , 2012 | Pubmed ID: 23243436
A novel Danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways.
International journal of cardiology Sep, 2013 | Pubmed ID: 23290949
The novel tetramethylpyrazine bis-nitrone (TN-2) protects against MPTP/MPP+-induced neurotoxicity via inhibition of mitochondrial-dependent apoptosis.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology Mar, 2014 | Pubmed ID: 24233519
Therapeutic effects of multifunctional tetramethylpyrazine nitrone on models of Parkinson's disease in vitro and in vivo.
Biological & pharmaceutical bulletin , 2014 | Pubmed ID: 24305623
Neuroprotective effects of the andrographolide analogue AL-1 in the MPP⁺/MPTP-induced Parkinson's disease model in vitro and in mice.
Pharmacology, biochemistry, and behavior Jul, 2014 | Pubmed ID: 24726706
Protective effect of chinonin in MPTP-induced C57BL/6 mouse model of Parkinson's disease.
Biological & pharmaceutical bulletin , 2014 | Pubmed ID: 24871044
Online two-dimensional porous graphitic carbon/reversed phase liquid chromatography platform applied to shotgun proteomics and glycoproteomics.
Analytical chemistry Dec, 2014 | Pubmed ID: 25393709
Inhibiting β-amyloid-associated Alzheimer's pathogenesis in vitro and in vivo by a multifunctional dimeric bis(12)-hupyridone derived from its natural analogue.
Journal of molecular neuroscience : MN Apr, 2015 | Pubmed ID: 25407821
A versatile reversed phase-strong cation exchange-reversed phase (RP-SCX-RP) multidimensional liquid chromatography platform for qualitative and quantitative shotgun proteomics.
The Analyst Feb, 2015 | Pubmed ID: 25554751
Pharmacokinetic and Metabolic Studies of ADTM: A Novel Danshensu Derivative Confers Cardioprotection by HPLC-UV and LC-MS/MS.
Journal of chromatographic science Jul, 2015 | Pubmed ID: 25609599
Andrographolide derivative AL-1 improves insulin resistance through down-regulation of NF-κB signalling pathway.
British journal of pharmacology Jun, 2015 | Pubmed ID: 25712508
Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease.
Free radical biology & medicine Jul, 2015 | Pubmed ID: 25769424
Relaxation effect of a novel Danshensu/tetramethylpyrazine derivative on rat mesenteric arteries.
European journal of pharmacology Aug, 2015 | Pubmed ID: 25952729
Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy.
Scientific reports Jun, 2015 | Pubmed ID: 26037049
Corrigendum: Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy.
Scientific reports Sep, 2015 | Pubmed ID: 26329261
Fully automated multidimensional reversed-phase liquid chromatography with tandem anion/cation exchange columns for simultaneous global endogenous tyrosine nitration detection, integral membrane protein characterization, and quantitative proteomics mapping in cerebral infarcts.
Analytical chemistry Oct, 2015 | Pubmed ID: 26335518
Indirubin-3-Oxime Effectively Prevents 6OHDA-Induced Neurotoxicity in PC12 Cells via Activating MEF2D Through the Inhibition of GSK3β.
Journal of molecular neuroscience : MN Dec, 2015 | Pubmed ID: 26346600
Online coupling of hydrophilic interaction/strong cation exchange/reversed-phase liquid chromatography with porous graphitic carbon liquid chromatography for simultaneous proteomics and N-glycomics analysis.
Journal of chromatography. A Oct, 2015 | Pubmed ID: 26362810
Protective effects of andrographolide derivative AL-1 on high glucose-induced oxidative stress in RIN-m cells.
Current pharmaceutical design , 2016 | Pubmed ID: 26391852
Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury.
Oxidative medicine and cellular longevity , 2015 | Pubmed ID: 26557222
Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice.
ACS chemical neuroscience Aug, 2016 | Pubmed ID: 27046396
Multifunction of Chrysin in Parkinson's Model: Anti-Neuronal Apoptosis, Neuroprotection via Activation of MEF2D, and Inhibition of Monoamine Oxidase-B.
Journal of agricultural and food chemistry Jul, 2016 | Pubmed ID: 27245668
Discovery, Synthesis, and Functional Characterization of a Novel Neuroprotective Natural Product from the Fruit of Alpinia oxyphylla for use in Parkinson's Disease Through LC/MS-Based Multivariate Data Analysis-Guided Fractionation.
Journal of proteome research Aug, 2016 | Pubmed ID: 27246451
Potent Protection Against MPP(+)-Induced Neurotoxicity via Activating Transcription Factor MEF2D by a Novel Derivative of Naturally Occurring Danshensu/Tetramethylpyrazine.
Neuromolecular medicine Dec, 2016 | Pubmed ID: 27277280
Design, synthesis and evaluation of novel dual monoamine-cholinesterase inhibitors as potential treatment for Alzheimer's disease.
Neuropharmacology Oct, 2016 | Pubmed ID: 27318273
Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway.
Cellular and molecular neurobiology May, 2017 | Pubmed ID: 27412761
Andrographolide derivative AL-1 ameliorates TNBS-induced colitis in mice: involvement of NF-кB and PPAR-γ signaling pathways.
Scientific reports Jul, 2016 | Pubmed ID: 27435110
Neuroprotection against glutamate-induced excitotoxicity and induction of neurite outgrowth by T-006, a novel multifunctional derivative of tetramethylpyrazine in neuronal cell models.
Neurochemistry international Oct, 2016 | Pubmed ID: 27445088
Tetramethylpyrazine Nitrone Improves Neurobehavioral Functions and Confers Neuroprotection on Rats with Traumatic Brain Injury.
Neurochemical research Nov, 2016 | Pubmed ID: 27452038
Design, Synthesis, and Biological Evaluation of Novel Tetramethylpyrazine Derivatives as Potential Neuroprotective Agents.
Chemical & pharmaceutical bulletin Jan, 2017 | Pubmed ID: 27746410
Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy.
Scientific reports Nov, 2016 | Pubmed ID: 27841332
Characterization of the Molecular Mechanisms Underlying the Chronic Phase of Stroke in a Cynomolgus Monkey Model of Induced Cerebral Ischemia.
Journal of proteome research Mar, 2017 | Pubmed ID: 28102082
Neuroprotective Effects and Mechanisms of Action of Multifunctional Agents Targeting Free Radicals, Monoamine Oxidase B and Cholinesterase in Parkinson's Disease Model.
Journal of molecular neuroscience : MN Apr, 2017 | Pubmed ID: 28144826
Tetramethylpyrazine nitrone protects retinal ganglion cells against N-methyl-d-aspartate-induced excitotoxicity.
Journal of neurochemistry May, 2017 | Pubmed ID: 28160291
Neuroprotective and axonal outgrowth-promoting effects of tetramethylpyrazine nitrone in chronic cerebral hypoperfusion rats and primary hippocampal neurons exposed to hypoxia.
Neuropharmacology May, 2017 | Pubmed ID: 28342896
Synthesis and Biological Evaluation of Danshensu and Tetramethylpyrazine Conjugates as Cardioprotective Agents.
Chemical & pharmaceutical bulletin , 2017 | Pubmed ID: 28381679
Lin Jiajia*,1,
Mak Shinghung*,2,
Zheng Jiacheng1,
Wang Jialing1,
Xu Dilin1,
Hu Shengquan2,
Zhang Zaijun3,
Wang Qinwen1,
Han Yifan2,4,
Cui Wei1,2
1Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University,
2Department of Applied Biology and Chemistry Technology, Institute of Modern Chinese Medicine, The Hong Kong Polytechnic University,
3Institute of New Drug Research, Guangdong Provincial Key Laboratory of Pharmacodynamic, Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy, Jinan University,
4, International Joint Laboratory (SYSU-PolyU HK) of Novel Anti-Dementia Drugs of Guangdong
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