Department of Chemistry,
The Centre for Research in Mass Spectrometry,
The Centre for Research on Biomolecular Interactions
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Mechanistic studies on enzymatic reactions by electrospray ionization MS using a capillary mixer with adjustable reaction chamber volume for time-resolved measurements.
Analytical chemistry May, 2004 | Pubmed ID: 15117195
Subunit disassembly and unfolding kinetics of hemoglobin studied by time-resolved electrospray mass spectrometry.
Biochemistry Nov, 2004 | Pubmed ID: 15544350
Kinetic unfolding mechanism of the inducible nitric oxide synthase oxygenase domain determined by time-resolved electrospray mass spectrometry.
Biochemistry Feb, 2005 | Pubmed ID: 15709740
Pulsed hydrogen exchange and electrospray charge-state distribution as complementary probes of protein structure in kinetic experiments: implications for ubiquitin folding.
Biochemistry Jun, 2005 | Pubmed ID: 15952769
Ultrarapid desalting of protein solutions for electrospray mass spectrometry in a microchannel laminar flow device.
Analytical chemistry Nov, 2005 | Pubmed ID: 16255586
A capillary mixer with adjustable reaction chamber volume for millisecond time-resolved studies by electrospray mass spectrometry.
Analytical chemistry Dec, 2003 | Pubmed ID: 16465695
Protein folding mechanisms studied by time-resolved electrospray mass spectrometry.
BioTechniques Feb, 2006 | Pubmed ID: 16526400
Hydrogen/deuterium scrambling during quadrupole time-of-flight MS/MS analysis of a zinc-binding protein domain.
Analytical chemistry Jan, 2007 | Pubmed ID: 17194133
A versatile microfluidic chip for millisecond time-scale kinetic studies by electrospray mass spectrometry.
Journal of the American Society for Mass Spectrometry Jan, 2009 | Pubmed ID: 18845447
Binding interactions in early- and late-stage amyloid aggregates of TTR(105-115).
Biophysical chemistry Sep, 2009 | Pubmed ID: 19501449
A microfluidic reactor for rapid, low-pressure proteolysis with on-chip electrospray ionization.
Rapid communications in mass spectrometry : RCM Feb, 2010 | Pubmed ID: 20049884
Rational manipulation of amyloidogenesis using an atomic level map of peptide-fibril interactions.
Biochemistry Jul, 2010 | Pubmed ID: 20560641
Understanding and optimizing electrospray ionization techniques for proteomic analysis.
Expert review of proteomics Apr, 2011 | Pubmed ID: 21501013
Kinetic capillary electrophoresis with mass-spectrometry detection (KCE-MS) facilitates label-free solution-based kinetic analysis of protein-small molecule binding.
Chembiochem : a European journal of chemical biology Nov, 2011 | Pubmed ID: 22012742
Measuring dynamics in weakly structured regions of proteins using microfluidics-enabled subsecond H/D exchange mass spectrometry.
Analytical chemistry Apr, 2012 | Pubmed ID: 22458633
Specific disruption of transthyretin(105-115) fibrilization using "stabilizing" inhibitors of transthyretin amyloidogenesis.
Biochemistry Apr, 2012 | Pubmed ID: 22482799
Time-resolved mass spectrometry for monitoring millisecond time-scale solution-phase processes.
European journal of mass spectrometry (Chichester, England) , 2012 | Pubmed ID: 22641726
Conformer selection and intensified dynamics during catalytic turnover in chymotrypsin.
Angewandte Chemie (International ed. in English) Sep, 2012 | Pubmed ID: 22936643
An electrospray ms-coupled microfluidic device for sub-second hydrogen/deuterium exchange pulse-labelling reveals allosteric effects in enzyme inhibition.
Lab on a chip Jul, 2013 | Pubmed ID: 23426018
Measuring kinetic isotope effects in enzyme reactions using time-resolved electrospray mass spectrometry.
Analytical chemistry Apr, 2013 | Pubmed ID: 23461634
Characterizing rapid, activity-linked conformational transitions in proteins via sub-second hydrogen deuterium exchange mass spectrometry.
The FEBS journal Nov, 2013 | Pubmed ID: 23663649
Oxidative protein labeling with analysis by mass spectrometry for the study of structure, folding, and dynamics.
Antioxidants & redox signaling Jul, 2014 | Pubmed ID: 24512178
An improved rapid mixing device for time-resolved electrospray mass spectrometry measurements.
ChemistryOpen Jun, 2014 | Pubmed ID: 25050229
Kinetic size-exclusion chromatography with mass spectrometry detection: an approach for solution-based label-free kinetic analysis of protein-small molecule interactions.
Analytical chemistry Oct, 2014 | Pubmed ID: 25275785
Changes in signal transducer and activator of transcription 3 (STAT3) dynamics induced by complexation with pharmacological inhibitors of Src homology 2 (SH2) domain dimerization.
The Journal of biological chemistry Nov, 2014 | Pubmed ID: 25288792
Unambiguous characterization of analytical markers in complex, seized opiate samples using an enhanced ion mobility trace detector-mass spectrometer.
Analytical chemistry Nov, 2014 | Pubmed ID: 25302672
Pre-equilibration kinetic size-exclusion chromatography with mass spectrometry detection (peKSEC-MS) for label-free solution-based kinetic analysis of protein-small molecule interactions.
The Analyst Feb, 2015 | Pubmed ID: 25611307
Hyperphosphorylation of intrinsically disordered tau protein induces an amyloidogenic shift in its conformational ensemble.
PloS one , 2015 | Pubmed ID: 25767879
Comparing equilibrium and kinetic protein unfolding using time-resolved electrospray-coupled ion mobility mass spectrometry.
The Analyst Oct, 2015 | Pubmed ID: 26115375
Dimerization of the type IV pilin from Pseudomonas aeruginosa strain K122-4 results in increased helix stability as measured by time-resolved hydrogen-deuterium exchange.
Structural dynamics (Melville, N.Y.) Jan, 2016 | Pubmed ID: 26798830
Conformational Dynamics and Allostery in Pyruvate Kinase.
The Journal of biological chemistry Apr, 2016 | Pubmed ID: 26879751
Signal transducer and activator of transcription 3 (STAT3) inhibitor, S3I-201, acts as a potent and non-selective alkylating agent.
Oncotarget Apr, 2016 | Pubmed ID: 26942696
Differential Mobility Spectrometry-Hydrogen Deuterium Exchange (DMS-HDX) as a Probe of Protein Conformation in Solution.
Journal of the American Society for Mass Spectrometry Jun, 2016 | Pubmed ID: 26965162
Hydrogen deuterium exchange mass spectrometry in biopharmaceutical discovery and development - A review.
Analytica chimica acta Oct, 2016 | Pubmed ID: 27662755
Potent Inhibition of 3-Deoxy-d-arabinoheptulosonate-7-phosphate (DAHP) Synthase by DAHP Oxime, a Phosphate Group Mimic.
Biochemistry Dec, 2016 | Pubmed ID: 27933795
Distinct Dynamic Modes Enable the Engagement of Dissimilar Ligands in a Promiscuous Atypical RNA Recognition Motif.
Biochemistry Dec, 2016 | Pubmed ID: 27959512
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